Protein detail

CD2

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Entry name CD2	UniProt ID P06729	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Protein Class (4)

CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

210..235; Helical

Transmembrane Count

Ensembl

ENSG00000116824

Entrez Gene Symbol

CD2

Gene Synonym

SRBC

Gene Description

CD2 molecule

Chromosome

Position

116754430-116769229

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg

Function & Pathway

Protein Function (3)

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component (9)

Molecular Function (5)

Biological Process (3)

KEGG (3)

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence181

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Receiver	Plasma Membrane (Transmembrane)
cell_surface	cell_surface	Baccin2019		Yes
cell_surface	cell_surface	OmniPath		Yes
receptor	receptor	Cellinker	Yes	Yes
receptor	receptor	scConnect	Yes	Yes
receptor	receptor	connectomeDB2020	Yes	Yes
receptor	receptor	CellCellInteractions	Yes	Yes
transmembrane	transmembrane_predicted	Phobius		Yes
transmembrane_phobius	transmembrane_predicted	Almen2009		Yes
transmembrane_sosui	transmembrane_predicted	Almen2009		Yes
transmembrane_tmhmm	transmembrane_predicted	Almen2009		Yes

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Protein Complex Composition (130)

130 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CD247	P20963	2	PDB	PDB:2hac
CD247 SHC1	P20963 P29353	1:1	PDB	PDB:1tce
CD247 ZAP70	P20963 P43403	1:1	PDB	PDB:4xz1PDB:2oq1
ATM ATR BLM FANCD2 MLH1 MRE11 MSH2 RAD50 RFC1 TXN2	P35251 P40692 P43246 P49959 P54132 Q13315 Q13535 Q92878 Q99757 Q9BXW9	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9169
ATM BLM FANCD2 MLH1 MRE11 MSH2 RAD50 RFC1	P35251 P40692 P43246 P49959 P54132 Q13315 Q92878 Q9BXW9	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9512
NUDCD2 PEX19 PPIAL4A PXN SMS	P40855 P49023 P52788 Q8WVJ2 Q9Y536	0:0:0:0:0	Havugimana2012	Havugimana2012:C_476
CD209 FAM217B NEU2 PEX5 TFAP4	P50542 Q01664 Q9NNX6 Q9NTX9 Q9Y3R4	0:0:0:0:0	hu.MAP2
CIP2A DDX20 FANCD2 GEMIN4 SAAL1 XPO4	P57678 Q8TCG1 Q96ER3 Q9BXW9 Q9C0E2 Q9UHI6	0:0:0:0:0:0	hu.MAP
FANCD2 FANCI UBA52	P62987 Q9BXW9 Q9NVI1	1:1:1	PDB	PDB:7zf1
AUP1 CHP1 GPAT3 GPAT4 HACD2 SLC6A15 TEX2	Q53EU6 Q6Y1H2 Q86UL3 Q8IWB9 Q99653 Q9H2J7 Q9Y679	0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	23161513

Sequence, Structure & Domains

Sequences

Length

351

Mass

39,448

Sequence

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN

3D Structural Models

Turn

88..90; 139..142

Helix

62..64; 73..75; 99..101

Beta Strand

31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203

3D Structure

NMR spectroscopy (3); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues

Domain (FT)

25..128; Ig-like V-type; 129..209; Ig-like C2-type

Region

61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases (2)

Lymphoma Psoriasis

Biomarker

Phase 2; Discontinued in Phase 2

Drug Targets

FDA approved drug targets

Drugs (9)

ZINC CHLORIDE SIPLIZUMAB [3H]HEMICHOLINIUM-3 OCTREOTIDE ACETATE RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ALDESLEUKIN ALEFACEPT COBALT HEMICHOLINIUM-3

Antibody (2)

CAB002430 HPA003883

Interaction Protein (4)

ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Related sentences
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No related sentences available