Protein detail
CEAM5
Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)
Entry name CEAM5 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)
Protein Class
Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CD66eCEA
Gene Description
CEA cell adhesion molecule 5
Chromosome
19
Position
41708585-41730433
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M162 Pid rxr vdr pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| cell_adhesion | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | No | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | No |
| ig_like | adhesion | Almen2009 | Yes | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
702
Mass
76,796
Sequence
MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06731-1; Sequence=Displayed; Name=2; IsoId=P06731-2; Sequence=VSP_053414
Alternative Sequence
320; Missing (in isoform 2)
3D Structural Models
Turn
84..87; 514..516; 551..554; 660..662
Helix
75..77; 114..116; 563..565
Beta Strand
37..46; 51..57; 60..72; 78..83; 88..91; 99..101; 107..109; 118..126; 132..141; 505..508; 519..524; 531..536; 547..550; 555..558; 569..577; 597..600; 611..616; 624..629; 632..642; 651..658; 665..673
3D Structure
Electron microscopy (2); NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
35..144; Ig-like V-type; 145..232; Ig-like C2-type 1; 240..315; Ig-like C2-type 2; 323..410; Ig-like C2-type 3; 418..495; Ig-like C2-type 4; 501..588; Ig-like C2-type 5; 593..675; Ig-like C2-type 6
Protein Families
- Immunoglobulin superfamily
- CEA family
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.
Clinical Relevance
Disease Involvement
Cancer-related genesOncogene
Drugs
COL-1NULLCARCINOEMBRYONIC ANTIGEN-EXPRESSING MEASLES VIRUSMEDI-565GEFITINIBCERGUTUZUMAB AMUNALEUKINYTTRIUM Y 90 ANTI-CEA MONOCLONAL ANTIBODY CT84.66TUSAMITAMAB RAVTANSINET84.66GENISTEINARCITUMOMABLABETUZUMABCALCIUM GLUCONATEMONOCLONAL ANTIBODY 3H1 ANTI-IDIOTYPE VACCINEANTISENSE OLIGONUCLEOTIDES90Y-CT84.66GI-6207ANTI-CEA CAR T CELLSLABETUZUMAB GOVITECANYTTRIUM Y 90 LABETUZUMABANTI-CEA/ANTI-HSG BISPECIFIC MONOCLONAL ANTIBODY TF2CARCINOEMBRYONIC ANTIGEN PEPTIDE 1-6D VIRUS-LIKE REPLICON PARTICLES VACCINE