Protein detail
CEAM5
Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)
Entry name CEAM5 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cell adhesion molecule CEACAM5 (Carcinoembryonic antigen) (CEA) (Carcinoembryonic antigen-related cell adhesion molecule 5) (CEA cell adhesion molecule 5) (Meconium antigen 100) (CD antigen CD66e)
Protein Class (5)
Cancer-related genesCD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD66eCEA
Gene Description
CEA cell adhesion molecule 5
Chromosome
19
Position
41708585-41730433
Supporting publications (n)
4
EVMP confidence score
0.38
Function & Pathway7
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function (4)
Biological Process (3)
Reactome (4)
Canonical Pathways
M162 Pid rxr vdr pathway
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence38
Ligand-Receptor Signaling (36)
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| ligand | ligand | ICELLNET | Yes | No | No | No | No |
| ligand | ligand | CellTalkDB | Yes | No | No | No | No |
| ligand | ligand | LRdb | Yes | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains12
Sequences
Length
702
Mass
76,796
Sequence
MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06731-1; Sequence=Displayed; Name=2; IsoId=P06731-2; Sequence=VSP_053414
Alternative Sequence
320; Missing (in isoform 2)
3D Structural Models
Turn
84..87; 514..516; 551..554; 660..662
Helix
75..77; 114..116; 563..565
Beta Strand
37..46; 51..57; 60..72; 78..83; 88..91; 99..101; 107..109; 118..126; 132..141; 505..508; 519..524; 531..536; 547..550; 555..558; 569..577; 597..600; 611..616; 624..629; 632..642; 651..658; 665..673
3D Structure
Electron microscopy (2); NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
35..144; Ig-like V-type; 145..232; Ig-like C2-type 1; 240..315; Ig-like C2-type 2; 323..410; Ig-like C2-type 3; 418..495; Ig-like C2-type 4; 501..588; Ig-like C2-type 5; 593..675; Ig-like C2-type 6
Protein Families (2)
- Immunoglobulin superfamily
- CEA family
Sequence Similarities
Belongs to the immunoglobulin superfamily. CEA family.
Clinical Relevance3
Disease Involvement (2)
Cancer-related genesOncogene
Drugs (22)
COL-1NULLCARCINOEMBRYONIC ANTIGEN-EXPRESSING MEASLES VIRUSMEDI-565GEFITINIBCERGUTUZUMAB AMUNALEUKINYTTRIUM Y 90 ANTI-CEA MONOCLONAL ANTIBODY CT84.66TUSAMITAMAB RAVTANSINET84.66GENISTEINARCITUMOMABLABETUZUMABCALCIUM GLUCONATEMONOCLONAL ANTIBODY 3H1 ANTI-IDIOTYPE VACCINEANTISENSE OLIGONUCLEOTIDES90Y-CT84.66GI-6207ANTI-CEA CAR T CELLSLABETUZUMAB GOVITECANYTTRIUM Y 90 LABETUZUMABANTI-CEA/ANTI-HSG BISPECIFIC MONOCLONAL ANTIBODY TF2CARCINOEMBRYONIC ANTIGEN PEPTIDE 1-6D VIRUS-LIKE REPLICON PARTICLES VACCINE
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No abstract available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No abstract available |
| 38136601 | Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |