Protein detail
FCER2
Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]
Entry name FCER2 | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form]
Protein Class
Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
- Predicted intracellular proteins
Transmembrane
22..47; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD23CD23ACLEC4JFCE2FcepsilonRIIFCErII
Gene Description
Fc epsilon receptor II
Chromosome
19
Position
7688758-7702146
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEpendymal cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-2197563 notch2 intracellular domain regulates transcription
- R-hsa-449147 signaling by interleukins
- R-hsa-157118 signaling by notch
- R-hsa-1980145 signaling by notch2
Canonical Pathways
- M138 Pid thrombin par4 pathway
- M155 Pid s1p meta pathway
- M268 Pid s1p s1p2 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 32230970 |
Sequence, Structure & Domains
Sequences
Length
321
Mass
36,469
Sequence
MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS
3D Structural Models
Turn
227..230; 247..252; 253..256
Helix
184..193; 204..211
Beta Strand
159..162; 164..166; 168..170; 173..182; 196..198; 215..217; 219..226; 231..234; 259..262; 264..266; 268..271; 277..285; 287..289; 291..294
3D Structure
NMR spectroscopy (2); X-ray crystallography (21)
Domain & Motif Annotations
Repeat
69..89; 90..110; 111..131
Domain (FT)
162..284; C-type lectin
Region
66..85; Disordered; 290..321; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs