Protein detail
ITAV
Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Protein symbol ITAV | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Protein Class
Cancer-related genesCD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
993..1016; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD51MSK8VNRAVTNR
Gene Description
Integrin subunit alpha V
Chromosome
2
Position
186590010-186680901
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificbrainBrain Regional Specificbasal gangliaCell SpecificCone photoreceptor cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0031258 lamellipodium membrane
- GO:0031527 filopodium membrane
- GO:0031528 microvillus membrane
- GO:0032587 ruffle membrane
- GO:0034682 integrin alphav-beta1 complex
- GO:0034683 integrin alphav-beta3 complex
- GO:0034684 integrin alphav-beta5 complex
- GO:0034685 integrin alphav-beta6 complex
- GO:0034686 integrin alphav-beta8 complex
- GO:0035579 specific granule membrane
- GO:0035866 alphav-beta3 integrin-PKCalpha complex
- GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
- GO:0035868 alphav-beta3 integrin-HMGB1 complex
- GO:0045335 phagocytic vesicle
- GO:0070062 extracellular exosome
Molecular Function
- GO:0001618 virus receptor activity
- GO:0001846 opsonin binding
- GO:0001968 fibronectin binding
- GO:0002020 protease binding
- GO:0005080 protein kinase C binding
- GO:0005178 integrin binding
- GO:0005245 voltage-gated calcium channel activity
- GO:0005515 protein binding
- GO:0015026 coreceptor activity
- GO:0017134 fibroblast growth factor binding
- GO:0019960 C-X3-C chemokine binding
- GO:0031994 insulin-like growth factor I binding
- GO:0038132 neuregulin binding
- GO:0046872 metal ion binding
- GO:0050431 transforming growth factor beta binding
- GO:0050840 extracellular matrix binding
- GO:1990430 extracellular matrix protein binding
Biological Process
KEGG
- hsa04081 Hormone signaling
- KEGG:hsa04145 Phagosome
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04514 Cell adhesion molecule (CAM) interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05222 Small cell lung cancer
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1236973 cross presentation of particulate exogenous antigens phagosomes
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-216083 integrin cell surface interactions
- R-hsa-373760 l1cam interactions
- R-hsa-3000157 laminin interactions
- R-hsa-9856532 mechanical load activates signaling by piezo1 and integrins in osteocytes
- R-hsa-2129379 molecules associated with elastic fibres
- R-hsa-9675108 nervous system development
- R-hsa-6798695 neutrophil degranulation
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-210990 pecam1 interactions
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-194138 signaling by vegf
- R-hsa-445144 signal transduction by l1
- R-hsa-3000170 syndecan interactions
- R-hsa-2173789 tgf beta receptor signaling activates smads
- R-hsa-9860927 turbulent oscillatory disturbed flow shear stress activates signaling by piezo1 and integrins in endothelial cells
Canonical Pathways
- M45 Pid cd40 pathway
- M12705 Sig cd40pathwaymap
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
72 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| integrin | matrix_adhesion | Integrins | No | Yes | No | Yes | No |
| integrin | matrix_adhesion | UniProt_keyword | No | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | Yes | No |
| integrin | matrix_adhesion | Almen2009 | No | Yes | No | Yes | No |
| integrin | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ITGAV-P2RY2-GNA12 complex | GNA12ITGAVP2RY2 | P06756P41231Q03113 | 1:1:1 | CompleatCORUM | CORUM:3110Compleat:HC770 | 17452627 |
| ITGAVKRT14KRT3KRT5 | P02533P06756P12035P13647 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_300 | ||
| ITGAVKRT3MCATPTPN1SHMT1 | P06756P12035P18031P34896Q8IVS2 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_453 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blotting | 1 | 37922300 |
Sequence, Structure & Domains
Sequences
Length
1,048
Mass
116,038
Sequence
MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P06756-1; Sequence=Displayed; Name=2; IsoId=P06756-2; Sequence=VSP_024351; Name=3; IsoId=P06756-3; Sequence=VSP_044914
Alternative Sequence
1..62; MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASS -> MLLGTLLLILYILMLC (in isoform 3); 175..211; QDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQG -> R (in isoform 2)
3D Structural Models
Turn
45..50; 178..184; 288..290; 352..354; 529..532; 544..546; 595..597; 627..630; 798..802; 904..906
Helix
206..209; 218..223; 245..247; 276..279; 397..399; 457..459; 575..577; 935..938
Beta Strand
35..37; 39..42; 51..56; 60..62; 65..70; 85..95; 97..100; 109..111; 114..118; 126..131; 134..139; 147..150; 157..162; 165..169; 174..176; 189..193; 197..203; 211..217; 235..239; 254..259; 261..266; 268..273; 282..286; 293..298; 308..313; 316..319; 322..327; 331..333; 335..337; 339..341; 344..350; 356..362; 364..368; 370..372; 374..378; 383..385; 387..392; 402..409; 410..413; 418..422; 428..430; 436..442; 447..449; 451..456; 461..465; 470..485; 486..488; 489..492; 494..496; 502..512; 514..516; 519..528; 535..537; 541..543; 547..558; 559..561; 564..572; 581..583; 585..593; 601..603; 610..612; 614..623; 636..641; 646..648; 653..663; 668..670; 672..676; 681..686; 691..693; 697..701; 703..705; 708..712; 715..717; 722..731; 735..737; 739..748; 752..754; 760..767; 772..786; 805..814; 816..818; 820..833; 839..856; 900..902; 907..916; 923..933; 941..944; 948..960; 964..966; 971..982
3D Structure
Electron microscopy (29); X-ray crystallography (26)
Domain & Motif Annotations
Compositional Bias
1027..1042; Basic and acidic residues
Repeat
32..98; FG-GAP 1; 109..170; FG-GAP 2; 173..225; FG-GAP 3; 237..291; FG-GAP 4; 292..357; FG-GAP 5; 358..415; FG-GAP 6; 419..482; FG-GAP 7
Motif
1019..1023; GFFKR motif
Region
1027..1048; Disordered
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Related Diseases
Biomarker
Phase 2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000082781ENSG00000259207
Interaction Count
2
Interaction Dataset
intact_biogrid