Protein detail
ASGR2
Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
Protein symbol ASGR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
59..79; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CLEC4H2
Gene Description
Asialoglycoprotein receptor 2
Chromosome
17
Position
7101322-7115700
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M64 Pid s1p s1p4 pathway
- M103 Pid s1p s1p1 pathway
- M155 Pid s1p meta pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ASGR2 | PRKCA | P17252 | S | 12 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASGR2 | PRKCB | P05771 | S | 12 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASGR2 | PRKCG | P05129 | S | 12 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASGR2 | PRKCD | Q05655 | S | 12 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASGR2 | PRKCE | Q02156 | S | 12 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ASGR2 | CSNK2A2 | P19784 | S | 12 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
| scavenger | receptor | HPMR | No | Yes | No | Yes | No |
| c_lectinn_containing_scavenger_scavenger | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
3 records.
Sequence, Structure & Domains
Sequences
Length
311
Mass
35,092
Sequence
MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P07307-1; Sequence=Displayed; Name=2; IsoId=P07307-2; Sequence=VSP_003060; Name=3; IsoId=P07307-3; Sequence=VSP_003060, VSP_003061
Alternative Sequence
24..42; Missing (in isoform 2 and isoform 3); 82..86; Missing (in isoform 3)
3D Structural Models
Helix
198..207; 218..228
Beta Strand
182..184; 187..191; 233..238; 278..281; 287..290; 296..303
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Motif
5..8; Endocytosis signal
Domain (FT)
176..302; C-type lectin
Region
1..44; Disordered