Protein detail

ASGR2

Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)

Entry name ASGR2	UniProt ID P07307	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)

Protein Class (3)

Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins

Transmembrane

59..79; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000161944

Entrez Gene Symbol

ASGR2

Gene Synonym

CLEC4H2

Gene Description

Asialoglycoprotein receptor 2

Chromosome

Position

7101322-7115700

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway8

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (5)

Biological Process (3)

KEGG

hsa04918 Thyroid hormone synthesis

Reactome (2)

Canonical Pathways (3)

M64 Pid s1p s1p4 pathway
M103 Pid s1p s1p1 pathway
M155 Pid s1p meta pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence54

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ASGR2	PRKCA	P17252	S	12	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ASGR2	PRKCB	P05771	S	12	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ASGR2	PRKCG	P05129	S	12	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ASGR2	PRKCD	Q05655	S	12	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ASGR2	PRKCE	Q02156	S	12	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ASGR2	CSNK2A2	P19784	S	12	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (44)

44 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
basolateral_cell_membrane	plasma_membrane	LOCATE	No	No	No	Yes	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ADIPOR2 ASGR2 MFSD8 MT-CO1 SERINC1 TMEM214	P00395 P07307 Q6NUQ4 Q86V24 Q8NHS3 Q9NRX5	0:0:0:0:0:0	hu.MAP2
ASGR2 MFSD8 SERINC1 TMEM214	P07307 Q6NUQ4 Q8NHS3 Q9NRX5	0:0:0:0	hu.MAP2
ADGRL3 ASGR2 SERINC1	P07307 Q9HAR2 Q9NRX5	0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	6	38731868 40784529 37686366 40098346 41201090 31320591

Sequence, Structure & Domains11

Sequences

Length

311

Mass

35,092

Sequence

MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGSQSEGHGGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRFVACQMELLHSNGSQRTCCPVNWVEHQGSCYWFSHSGKAWAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFNTWIGLTDSDGSWKWVDGTDYRHNYKNWAVTQPDNWHGHELGGSEDCVEVQPDGRWNDDFCLQVYRWVCEKRRNATGEVA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P07307-1; Sequence=Displayed; Name=2; IsoId=P07307-2; Sequence=VSP_003060; Name=3; IsoId=P07307-3; Sequence=VSP_003060, VSP_003061

Alternative Sequence

24..42; Missing (in isoform 2 and isoform 3); 82..86; Missing (in isoform 3)

3D Structural Models

Helix

198..207; 218..228

Beta Strand

182..184; 187..191; 233..238; 278..281; 287..290; 296..303

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

5..8; Endocytosis signal

Domain (FT)

176..302; C-type lectin

Region

1..44; Disordered

Clinical Relevance5

Drugs (4)

H+MG2+CS+BA2+

Antibody (2)

HPA014899 HPA015998

Interaction Protein

ENSG00000143418

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
39996590	Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.	No abstract available