Protein detail
ADH1A
Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha)
Entry name ADH1A | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha)
Protein Class (5)
EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (4)
- FDA approved drug targets:Small molecule drugs
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ADH1
Gene Description
Alcohol dehydrogenase 1A (class I), alpha polypeptide
Chromosome
4
Position
99276369-99291003
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificovaryCell SpecificOocytesSecretome LocationSecreted in female reproductive systemSecretome FunctionReceptor
Function & Pathway
Protein Function (4)
- FDA approved drug targets:Small molecule drugs
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (9)
- hsa00010 Glycolysis / Gluconeogenesis
- KEGG:hsa00071 Fatty acid degradation
- KEGG:hsa00350 Tyrosine metabolism
- KEGG:hsa00620 Pyruvate metabolism
- KEGG:hsa00830 Retinol metabolism
- KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450
- KEGG:hsa00982 Drug metabolism - cytochrome P450
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04936 Alcoholic liver disease
Reactome (8)
Canonical Pathways (3)
- M56 Pid lpa4 pathway
- M41 Pid er nongenomic pathway
- M8 Pid endothelin pathway
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence7
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient Centrifugation | Mass spectrometry | 1 | 32284825 |
Sequence, Structure & Domains
Sequences
Length
375
Mass
39,859
Sequence
MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF
3D Structural Models
Turn
142..144; 186..188; 259..261; 285..287
Helix
48..54; 102..105; 155..157; 167..170; 171..174; 176..185; 203..214; 227..229; 230..235; 244..246; 251..258; 273..282; 307..310; 320..322; 325..337; 344..346; 353..355; 356..364
Beta Strand
8..15; 23..29; 36..45; 62..65; 69..77; 89..92; 99..101; 116..119; 131..133; 136..139; 147..154; 158..160; 195..199; 218..223; 239..242; 263..268; 289..292; 302..304; 314..317; 347..352; 369..374
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Zinc-containing alcohol dehydrogenase family
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved
Drug Targets
FDA approved drug targets
Drugs (16)
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 41227296 | Extracellular Vesicles Profiling in Acute Myeloid Leukemia Cell Lines: A Proteomic Characterization. | No related sentences available |