Protein detail
ANXA2
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein symbol ANXA2 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count | Protein classification Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein Class
Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
ANX2ANX2L4CAL1HLIP2LPC2D
Gene Description
Annexin A2
Chromosome
15
Position
60347134-60402883
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0001533 cornified envelope
- GO:0005576 extracellular region
- GO:0005604 basement membrane
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005811 lipid droplet
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0009986 cell surface
- GO:0012506 vesicle membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016363 nuclear matrix
- GO:0030496 midbody
- GO:0031902 late endosome membrane
- GO:0031982 vesicle
- GO:0035578 azurophil granule lumen
- GO:0035749 myelin sheath adaxonal region
- GO:0042383 sarcolemma
- GO:0042470 melanosome
- GO:0043220 Schmidt-Lanterman incisure
- GO:0045121 membrane raft
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
- GO:0090575 RNA polymerase II transcription regulator complex
- GO:0098797 plasma membrane protein complex
- GO:1990665 AnxA2-p11 complex
- GO:1990667 PCSK9-AnxA2 complex
Molecular Function
- GO:0001786 phosphatidylserine binding
- GO:0002020 protease binding
- GO:0003723 RNA binding
- GO:0004867 serine-type endopeptidase inhibitor activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005544 calcium-dependent phospholipid binding
- GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
- GO:0008092 cytoskeletal protein binding
- GO:0019834 phospholipase A2 inhibitor activity
- GO:0042802 identical protein binding
- GO:0044548 S100 protein binding
- GO:0048306 calcium-dependent protein binding
- GO:0098641 cadherin binding involved in cell-cell adhesion
Biological Process
Reactome
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-75205 dissolution of fibrin clot
- R-hsa-8950505 gene and protein expression by jak stat signaling after interleukin 12 stimulation
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-447115 interleukin 12 family signaling
- R-hsa-9020591 interleukin 12 signaling
- R-hsa-397014 muscle contraction
- R-hsa-6798695 neutrophil degranulation
- R-hsa-449147 signaling by interleukins
- R-hsa-445355 smooth muscle contraction
- R-hsa-9860927 turbulent oscillatory disturbed flow shear stress activates signaling by piezo1 and integrins in endothelial cells
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
28 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ANXA2 | SRC | P12931 | Y | 24 | phosphorylation | BEL-Large-Corpus_ProtMapperSparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:25303710ProtMapper:25574848ProtMapper:23594883KEA:2456953ProtMapper:26716413phosphoELM:2456953ProtMapper:15212693SIGNOR:15302870dbPTM:18083107ProtMapper:27821486KEA:2143014dbPTM:15302870dbPTM:17389395KEA:88296872ProtMapper:15302870KEA:2415974dbPTM:17287340ProtMapper:30081903ProtMapper:24727000ProtMapper:24239898 |
| ANXA2 | SRC | P12931 | Y | 42 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:2456953KEA:88296872 |
| ANXA2 | SRC | P12931 | S | 26 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:25303710ProtMapper:23594883 |
| ANXA2 | SRC | P12931 | S | 12 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:25303710ProtMapper:23594883 |
| ANXA2 | SRC | P12931 | Y | 333 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:27821486 |
| ANXA2 | PRKCA | P17252 | S | 26 | phosphorylation | BEL-Large-Corpus_ProtMapperSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:15212693HPRD:18578522KEA:2946940ProtMapper:2946940HPRD:20068231HPRD:18669648phosphoELM:2946940KEA:2174397HPRD:2946940SIGNOR:2946940KEA:91065537HPRD:20166139 |
| ANXA2 | PRKCA | P17252 | S | 44 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | HPRD:18578522KEA:2946940HPRD:20068231HPRD:18669648HPRD:2946940KEA:91065537HPRD:20166139 |
| ANXA2 | PRKCA | P17252 | S | 12 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ANXA2 | PRKCA | P17252 | S | 30 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ANXA2 | PRKCB | P05771 | S | 2 | phosphorylation | HPRDSIGNOR_ProtMapperKEAProtMapper | KEA:8898866ProtMapper:8898866HPRD:8898866HPRD:20068231 |
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Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | No | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | No | No |
| ligand | ligand | ICELLNET | Yes | No | Yes | No | No |
| innate_immune | ligand | ICELLNET | Yes | No | Yes | No | No |
| innate_immune_tlr | ligand | ICELLNET | Yes | No | Yes | No | No |
Regulatory Interaction Network
7 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
339
Mass
38,604
Sequence
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091
Alternative Sequence
1; M -> MGRQLAGCGDAGKKASFKM (in isoform 2)
3D Structural Models
Turn
24..27; 201..204; 233..235; 296..298
Helix
4..12; 35..47; 53..60; 65..79; 83..90; 93..103; 106..117; 125..134; 137..151; 155..161; 165..175; 188..200; 210..219; 222..232; 240..247; 250..264; 266..278; 285..295; 300..311; 315..322; 325..335
Beta Strand
48..50; 120..122; 205..207; 236..238; 279..282
3D Structure
X-ray crystallography (40)
Domain & Motif Annotations
Repeat
33..104; Annexin 1; 105..176; Annexin 2; 189..261; Annexin 3; 265..336; Annexin 4
Domain (CC)
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Region
2..24; S100A10-binding site
Protein Families
Annexin family
Sequence Similarities
Belongs to the annexin family.
Clinical Relevance
Disease Involvement
Cancer-related genesFDA approved drug targets
Drug Targets
FDA approved drug targetsLiterature-reported targetClinical trial target
Drugs
Interaction Protein
ENSG00000076242ENSG00000132646ENSG00000146648ENSG00000197747
Interaction Count
4
Interaction Dataset
intact_biogrid