Protein detail

ANXA2

Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)

Entry name ANXA2	UniProt ID P07355	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)

Protein Class (7)

Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000182718

Entrez Gene Symbol

ANXA2

Gene Synonym (5)

ANX2ANX2L4CAL1HLIP2LPC2D

Gene Description

Annexin A2

Chromosome

Position

60347134-60402883

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBergmann gliaSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (33)

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Molecular Function (14)

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Biological Process (3)

KEGG

hsa05132 Salmonella infection

Reactome (17)

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Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence82

Enzyme-Mediated Modification (28)

28 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ANXA2	SRC	P12931	Y	24	phosphorylation	BEL-Large-Corpus_ProtMapperSparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:25303710 ProtMapper:25574848 ProtMapper:23594883 KEA:2456953 ProtMapper:26716413 phosphoELM:2456953 ProtMapper:15212693 SIGNOR:15302870 dbPTM:18083107 ProtMapper:27821486 KEA:2143014 dbPTM:15302870 dbPTM:17389395 KEA:88296872 ProtMapper:15302870 KEA:2415974 dbPTM:17287340 ProtMapper:30081903 ProtMapper:24727000 ProtMapper:24239898
ANXA2	SRC	P12931	Y	42	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:2456953 KEA:88296872
ANXA2	SRC	P12931	S	26	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:25303710 ProtMapper:23594883
ANXA2	SRC	P12931	S	12	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:25303710 ProtMapper:23594883
ANXA2	SRC	P12931	Y	333	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27821486
ANXA2	PRKCA	P17252	S	26	phosphorylation	BEL-Large-Corpus_ProtMapperSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:15212693 HPRD:18578522 KEA:2946940 ProtMapper:2946940 HPRD:20068231 HPRD:18669648 phosphoELM:2946940 KEA:2174397 HPRD:2946940 SIGNOR:2946940 KEA:91065537 HPRD:20166139
ANXA2	PRKCA	P17252	S	44	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:18578522 KEA:2946940 HPRD:20068231 HPRD:18669648 HPRD:2946940 KEA:91065537 HPRD:20166139
ANXA2	PRKCA	P17252	S	12	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
ANXA2	PRKCA	P17252	S	30	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ANXA2	PRKCB	P05771	S	2	phosphorylation	HPRDSIGNOR_ProtMapperKEAProtMapper	KEA:8898866 ProtMapper:8898866 HPRD:8898866 HPRD:20068231

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Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	connectomeDB2020	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	No	No
cell_surface	cell_surface	OmniPath	No	No	Yes	No	No
ligand	ligand	connectomeDB2020	Yes	No	Yes	No	No
ligand	ligand	ICELLNET	Yes	No	Yes	No	No
innate_immune	ligand	ICELLNET	Yes	No	Yes	No	No
innate_immune_tlr	ligand	ICELLNET	Yes	No	Yes	No	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UBAP2	Q5T6F2	ANXA2	P07355	Yes	No	Yes	SIGNOR	SIGNOR:27121050
YES	P07947	ANXA2	P07355	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	SIGNOR:33941853 ProtMapper:33941853
KPCA	P17252	ANXA2	P07355	Yes	No	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	PhosphoSite:11106498 PhosphoSite:23757730 PhosphoSite:20597553 HPRD-phos:18669648 HPRD:2946940 SIGNOR:2946940 PhosphoSite:21115493 PhosphoSite:18412141 ProtMapper:15212693 KEA:2946940 HPRD-phos:18578522 HPRD-phos:2946940 HPRD-phos:20068231 KEA:2174397 phosphoELM:2946940 PhosphoSite:12962548 ProtMapper:18578522 ProtMapper:2946940 ProtMapper:20166139 ProtMapper:20068231 ProtMapper:18669648 KEA:17570479 HPRD-phos:20166139 KEA:91065537
HAKAI	Q75N03	ANXA2	P07355	Yes	No	Yes	SIGNOR	SIGNOR:31952268
KPCB	P05771	ANXA2	P07355	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	SIGNOR:8898866 KEA:8898866 HPRD:8898866 ProtMapper:20068231 HPRD-phos:20068231 ProtMapper:8898866 HPRD-phos:8898866
SRC	P12931	ANXA2	P07355	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LC	ProtMapper:23691485 ProtMapper:21237296 ProtMapper:25303710 ProtMapper:25574848 ProtMapper:27385217 ProtMapper:23594883 KEA:2456953 HPRD:11106497 ProtMapper:26716413 phosphoELM:2456953 ProtMapper:15212693 SIGNOR:15302870 ProtMapper:20607799 dbPTM:18083107 ProtMapper:21572519 ProtMapper:27821486 KEA:2143014 dbPTM:15302870 dbPTM:17389395 KEA:88296872 ProtMapper:15302870 ProtMapper:32824910 KEA:2415974 dbPTM:17287340 ProtMapper:26644180 ProtMapper:30081903 ProtMapper:24727000 ProtMapper:24239898 SPIKE_LC:16189514
IGF1R	P08069	ANXA2	P07355	Yes	No	No	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:30081903 PhosphoSite:31113450 PhosphoSite:32615410 PhosphoSite:28470457 PhosphoSite:23555942 PhosphoSite:30738042 PhosphoSite:15302870 ProtMapper:27821486 PhosphoSite:26716413 PhosphoSite:27821486 PhosphoSite:26272794

Protein Complex Composition (13)

13 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ANXA2 HLTF	P07355 Q14527	2:2	PDB	PDB:4hrh
ANXA2 RPS6KA1	P07355 Q15418	2:1	PDB	PDB:7p74PDB:7qqlPDB:5n7dPDB:5n7gPDB:6twyPDB:5n7fPDB:7pc8
ANXA2 EXOC4	P07355 Q96A65	1:1	PDB	PDB:7pc5

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains14

Sequences

Length

339

Mass

38,604

Sequence

MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091

Alternative Sequence

1; M -> MGRQLAGCGDAGKKASFKM (in isoform 2)

3D Structural Models

Turn

24..27; 201..204; 233..235; 296..298

Helix

4..12; 35..47; 53..60; 65..79; 83..90; 93..103; 106..117; 125..134; 137..151; 155..161; 165..175; 188..200; 210..219; 222..232; 240..247; 250..264; 266..278; 285..295; 300..311; 315..322; 325..335

Beta Strand

48..50; 120..122; 205..207; 236..238; 279..282

3D Structure

X-ray crystallography (40)

Domain & Motif Annotations

Repeat

33..104; Annexin 1; 105..176; Annexin 2; 189..261; Annexin 3; 265..336; Annexin 4

Domain (CC)

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Region

2..24; S100A10-binding site

Protein Families

Annexin family

Sequence Similarities

Belongs to the annexin family.

Clinical Relevance7

Disease Involvement (2)

Cancer-related genesFDA approved drug targets

Drug Targets (3)

FDA approved drug targetsLiterature-reported targetClinical trial target

Drugs (12)

NEUROPEPTIDE S N-ETHYLMALEIMIDE [CY5-LYS19]NPS PI1 QA1 NPS(1-4)NH2 ANISTREPLASE NCGC 84 SHA 68R [125I]TYR10NPS (HUMAN)RTI-118 WITHAFERIN A

Antibody (3)

CAB004311 HPA046964 HPA061798

Interaction Protein (4)

ENSG00000076242ENSG00000132646ENSG00000146648ENSG00000197747

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
22708494	Multiple roles of annexin A2 in post-transcriptional regulation of gene expression.	Finally, the association of AnxA2 with endosomes and exosomes suggests a role in co-ordinated transport of mRNA and vesicles, i.e.
27574537	Extracellular vesicles released from cells exposed to reactive oxygen species increase annexin A2 expression and survival of target cells exposed to the same conditions.	No abstract available
28867585	Protein phosphorylation and its role in the regulation of Annexin A2 function.	The presence of AnxA2 in cancer cell-derived exosomes, as well as the potential regulation of exosomal AnxA2 by phosphorylation or other PTMs, are topics of great interest.
31992335	Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis.	Our previous studies have demonstrated annexin A2 (AnxA2) association with exosomes which promotes angiogenesis and metastasis.
36612209	Combination of Small Extracellular Vesicle-Derived Annexin A2 Protein and mRNA as a Potential Predictive Biomarker for Chemotherapy Responsiveness in Aggressive Triple-Negative Breast Cancer.	No abstract available