Protein detail

ANXA2

Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)

Entry name ANXA2	UniProt ID P07355	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)

Protein Class (7)

Cancer-related genesDisease related genesFDA approved drug targetsPlasma proteinsPredicted intracellular proteinsPredicted secreted proteinsTransporters

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Ensembl

ENSG00000182718

Entrez Gene Symbol

ANXA2

Gene Synonym (5)

ANX2ANX2L4CAL1HLIP2LPC2D

Gene Description

Annexin A2

Chromosome

Position

60347134-60402883

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBergmann gliaSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Candidate cancer biomarkers
Predicted secreted proteins
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (33)

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Molecular Function (14)

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Biological Process (3)

KEGG

hsa05132 Salmonella infection

Reactome (17)

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Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence82

Enzyme-Mediated Modification (28)

28 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ANXA2	BMX	P51813	Y	318	phosphorylation	PhosphoNetworks
ANXA2	PRKCG	P05129	S	44	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ANXA2	PRKCD	Q05655	S	44	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ANXA2	PRKCE	Q02156	S	44	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ANXA2	RAPGEF3	O95398	Y	24	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:30738042
ANXA2	INSR	P06213	Y	24	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:23519104
ANXA2	INS	P01308	Y	24	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:23519104
ANXA2	CSK	P41240	Y	24	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27385217 ProtMapper:23691485 ProtMapper:21237296

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Ligand-Receptor Signaling (33)

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	UniProt_location	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	No	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No

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Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
UBAP2	Q5T6F2	ANXA2	P07355	Yes	No	Yes	SIGNOR	SIGNOR:27121050
YES	P07947	ANXA2	P07355	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	SIGNOR:33941853 ProtMapper:33941853
KPCA	P17252	ANXA2	P07355	Yes	No	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	PhosphoSite:11106498 PhosphoSite:23757730 PhosphoSite:20597553 HPRD-phos:18669648 HPRD:2946940 SIGNOR:2946940 PhosphoSite:21115493 PhosphoSite:18412141 ProtMapper:15212693 KEA:2946940 HPRD-phos:18578522 HPRD-phos:2946940 HPRD-phos:20068231 KEA:2174397 phosphoELM:2946940 PhosphoSite:12962548 ProtMapper:18578522 ProtMapper:2946940 ProtMapper:20166139 ProtMapper:20068231 ProtMapper:18669648 KEA:17570479 HPRD-phos:20166139 KEA:91065537
HAKAI	Q75N03	ANXA2	P07355	Yes	No	Yes	SIGNOR	SIGNOR:31952268
KPCB	P05771	ANXA2	P07355	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	SIGNOR:8898866 KEA:8898866 HPRD:8898866 ProtMapper:20068231 HPRD-phos:20068231 ProtMapper:8898866 HPRD-phos:8898866
SRC	P12931	ANXA2	P07355	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LC	ProtMapper:23691485 ProtMapper:21237296 ProtMapper:25303710 ProtMapper:25574848 ProtMapper:27385217 ProtMapper:23594883 KEA:2456953 HPRD:11106497 ProtMapper:26716413 phosphoELM:2456953 ProtMapper:15212693 SIGNOR:15302870 ProtMapper:20607799 dbPTM:18083107 ProtMapper:21572519 ProtMapper:27821486 KEA:2143014 dbPTM:15302870 dbPTM:17389395 KEA:88296872 ProtMapper:15302870 ProtMapper:32824910 KEA:2415974 dbPTM:17287340 ProtMapper:26644180 ProtMapper:30081903 ProtMapper:24727000 ProtMapper:24239898 SPIKE_LC:16189514
IGF1R	P08069	ANXA2	P07355	Yes	No	No	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:30081903 PhosphoSite:31113450 PhosphoSite:32615410 PhosphoSite:28470457 PhosphoSite:23555942 PhosphoSite:30738042 PhosphoSite:15302870 ProtMapper:27821486 PhosphoSite:26716413 PhosphoSite:27821486 PhosphoSite:26272794

Protein Complex Composition (13)

13 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ANXA2-PCSK9 complex	ANXA2 PCSK9	P07355 Q8NBP7	1:1	ComplexPortal		18799458 14755292 22848640 14760721 24808179
S100A10-annexin 2 complex	ANXA2 S100A10	P07355 P60903	2:2	KEGG-MEDICUSComplexPortalCompleathu.MAP2hu.MAP	Compleat:HC736PDB:1a4pintact:EBI-12560506PDB:1bt6	17638009 12175151 15350136 3126079 9836589 14730666 11999733 14755292 22940583 9886297 1880797 11857757 11917092 6997045 12660155 9223619 2106685
SMARCA3 - Annexin A2 - S100-A10 complex	ANXA2 HLTF S100A10	P07355 P60903 Q14527	2:2:2	ComplexPortal	intact:EBI-12560849PDB:4hrgPDB:1bt6PDB:4hrhPDB:1a4pPDB:4hre	9886297 11917092 14755292 3126079
TRPV5-S100A10-annexin 2 complex	ANXA2 S100A10 TRPV5 TRPV6	P07355 P60903 Q9H1D0 Q9NQA5	1:1:1:1	Compleat	Compleat:HC1536	12660155
	ANXA2 TP53	P04637 P07355	1:1	PDB	PDB:7nmi
	ANXA2	P07355	2	PDB	PDB:7zvxPDB:6t58PDB:5lq0PDB:5lq2PDB:1xjlPDB:2hyw
	ANXA2 CTSB S100A10	P07355 P07858 P60903	1:1:1	CompleatCFinder	Compleat:HC6581
	ANXA2 S100A4	P07355 P26447	2:2	PDB	PDB:5lpu
	ANXA2 PTEN	P07355 P60484	2:2	PDB	PDB:7pc7
	ANXA2 S100A10 TMTC3	P07355 P60903 Q6ZXV5	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains14

Sequences

Length

339

Mass

38,604

Sequence

MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091

Alternative Sequence

1; M -> MGRQLAGCGDAGKKASFKM (in isoform 2)

3D Structural Models

Turn

24..27; 201..204; 233..235; 296..298

Helix

4..12; 35..47; 53..60; 65..79; 83..90; 93..103; 106..117; 125..134; 137..151; 155..161; 165..175; 188..200; 210..219; 222..232; 240..247; 250..264; 266..278; 285..295; 300..311; 315..322; 325..335

Beta Strand

48..50; 120..122; 205..207; 236..238; 279..282

3D Structure

X-ray crystallography (40)

Domain & Motif Annotations

Repeat

33..104; Annexin 1; 105..176; Annexin 2; 189..261; Annexin 3; 265..336; Annexin 4

Domain (CC)

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Region

2..24; S100A10-binding site

Protein Families

Annexin family

Sequence Similarities

Belongs to the annexin family.

Clinical Relevance7

Disease Involvement (2)

Cancer-related genesFDA approved drug targets

Drug Targets (3)

FDA approved drug targetsLiterature-reported targetClinical trial target

Drugs (12)

NEUROPEPTIDE S N-ETHYLMALEIMIDE [CY5-LYS19]NPS PI1 QA1 NPS(1-4)NH2 ANISTREPLASE NCGC 84 SHA 68R [125I]TYR10NPS (HUMAN)RTI-118 WITHAFERIN A

Antibody (3)

CAB004311 HPA046964 HPA061798

Interaction Protein (4)

ENSG00000076242ENSG00000132646ENSG00000146648ENSG00000197747

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
22708494	Multiple roles of annexin A2 in post-transcriptional regulation of gene expression.	Finally, the association of AnxA2 with endosomes and exosomes suggests a role in co-ordinated transport of mRNA and vesicles, i.e.
27574537	Extracellular vesicles released from cells exposed to reactive oxygen species increase annexin A2 expression and survival of target cells exposed to the same conditions.	No abstract available
28867585	Protein phosphorylation and its role in the regulation of Annexin A2 function.	The presence of AnxA2 in cancer cell-derived exosomes, as well as the potential regulation of exosomal AnxA2 by phosphorylation or other PTMs, are topics of great interest.
31992335	Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis.	Our previous studies have demonstrated annexin A2 (AnxA2) association with exosomes which promotes angiogenesis and metastasis.
36612209	Combination of Small Extracellular Vesicle-Derived Annexin A2 Protein and mRNA as a Potential Predictive Biomarker for Chemotherapy Responsiveness in Aggressive Triple-Negative Breast Cancer.	No abstract available