Protein detail

ADRB2

Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)

Protein symbol
ADRB2
UniProt ID
P07550
EVMP score
0.50
Frequency
1
Transmembrane count
7
Protein classification
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Protein Function
  • Transporters
  • Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
  • FDA approved drug targets:Small molecule drugs
Transmembrane
30..56; Helical; Name=1; 71..96; Helical; Name=2; 104..129; Helical; Name=3; 150..171; Helical; Name=4; 198..220; Helical; Name=5; 275..298; Helical; Name=6; 305..326; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000169252
Entrez Gene Symbol
ADRB2
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsBlood Cell SpecificbasophilSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function
  • Transporters
  • Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
  • G-protein coupled receptors:GPCRs excl olfactory receptors
  • Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
  • FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

63 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
ADRB2AKT1P31749S346phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:11809767SIGNOR:11809767
ADRB2AKT1P31749S204phosphorylationKEAKEA:9032240
ADRB2INSRP06213Y132phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperKEA:8557631SIGNOR:8557631KEA:8910597ProtMapper:8557631HPRD:8557631
ADRB2INSRP06213Y350phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperKEA:8557631KEA:8521811SIGNOR:8557631ProtMapper:8557631HPRD:8557631
ADRB2INSRP06213Y141phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperKEA:8557631KEA:8521811SIGNOR:8557631KEA:8910597ProtMapper:8557631HPRD:8557631KEA:17570479
ADRB2INSRP06213Y354phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperKEA:8557631KEA:8521811SIGNOR:8557631ProtMapper:8557631HPRD:8557631KEA:17570479
ADRB2PRKCDQ05655S261phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperProtMapper:1848190SIGNOR:1848190HPRD:1848190KEA:1848190
ADRB2PRKCDQ05655S346phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperProtMapper:1848190SIGNOR:1848190KEA:11809767HPRD:1848190KEA:11146000KEA:8083204KEA:1848190
ADRB2PRKCDQ05655S262phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperProtMapper:1848190SIGNOR:1848190HPRD:1848190KEA:11146000KEA:8083204KEA:1848190
ADRB2PRKCDQ05655S345phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperProtMapper:1848190SIGNOR:1848190HPRD:1848190KEA:11146000KEA:8083204KEA:1848190
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Ligand-Receptor Signaling

62 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoYesNo
transmembranetransmembraneUniProt_topologyNoNoNoYesNo
transmembranetransmembraneUniProt_keywordNoNoNoYesNo
transmembranetransmembraneGO_IntercellNoNoNoYesNo
transmembranetransmembraneCellPhoneDBNoNoNoYesNo
transmembranetransmembraneTopDBNoNoNoYesNo
transmembranetransmembraneLOCATENoNoNoYesNo
transmembranetransmembraneRamilowski_locationNoNoNoYesNo
transmembranetransmembraneOmniPathNoNoNoYesNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoYesNo
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Regulatory Interaction Network

16 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
ADRB2P07550GNAS3O95467YesYesNoKEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17BioGRID:12036966Lit-BM-17:23798571SIGNOR:31160049Lit-BM-17:12036966HINT:31740855HINT:38480881HINT:15782186CA1:6149763SIGNOR:14500986HINT:32655881Lit-BM-17:15782186
ADRB2P07550ALEXP84996YesYesNoKEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17BioGRID:12036966Lit-BM-17:23798571SIGNOR:31160049Lit-BM-17:12036966HINT:31740855HINT:38480881HINT:15782186CA1:6149763SIGNOR:14500986HINT:32655881Lit-BM-17:15782186
ADRB2P07550GNAS2P63092YesYesNoKEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17BioGRID:12036966Lit-BM-17:23798571SIGNOR:31160049Lit-BM-17:12036966HINT:31740855HINT:38480881HINT:15782186CA1:6149763SIGNOR:14500986HINT:32655881Lit-BM-17:15782186
ADRB2P07550GNAS1Q5JWF2YesYesNoKEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17BioGRID:12036966Lit-BM-17:23798571SIGNOR:31160049Lit-BM-17:12036966HINT:31740855HINT:38480881HINT:15782186CA1:6149763SIGNOR:14500986HINT:32655881Lit-BM-17:15782186
NHRF1O14745ADRB2P07550YesYesNoDOMINOWangSIGNORELMCui2007HINTHPRDBioGRIDCA1PDZBaseInnateDBLMPIDSPIKE_LCLit-BM-17BioGRID:11882663Lit-BM-17:9560162LMPID:11882663HPRD:9560162CA1:11882663BioGRID:9560162DOMINO:9671706LMPID:9671706Lit-BM-17:9671706HPRD:9671706SIGNOR:9671706Lit-BM-17:11882663InnateDB:15452121HINT:11882663HINT:9560162PDZBase:9671706ELM:11882663HINT:9671706InnateDB:11882663SPIKE_LC:9671706LMPID:9560162InnateDB:10499588Lit-BM-17:11526121HINT:10499588
KAPCAP17612ADRB2P07550YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperCui2007CA1InnateDBWangPhosphoSitePhosphoSite_ProtMapperPhosphoSite:27481942PhosphoSite:9461522PhosphoSite:27646272InnateDB:10753752PhosphoSite:24003153CA1:2987243PhosphoSite:11146000
INSRP06213ADRB2P07550YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEACellinkerSIGNOR_ProtMapperHPRD-phosNetworKIN_KEAKEA:8557631KEA:8521811SIGNOR:8557631Cellinker:28256297KEA:8910597ProtMapper:8557631HPRD-phos:8557631HPRD:8557631KEA:17570479
AKT1P31749ADRB2P07550YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:9032240PhosphoSite:11809767ProtMapper:11809767SIGNOR:11809767
KPCDQ05655ADRB2P07550YesNoYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosProtMapper:1848190HPRD-phos:1848190SIGNOR:1848190KEA:11809767HPRD:1848190KEA:11146000KEA:8083204KEA:1848190
GRK5P34947ADRB2P07550YesYesNoHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMCellinkerSIGNOR_ProtMapperphosphoELM:8662852Cellinker:28431242SIGNOR:8662852HPRD:8662852ProtMapper:9516468HINT:8672451KEA:96278816KEA:8662852ProtMapper:8662852HINT:8662852
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Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ADRB2 homodimer complexADRB2P075502CORUMPDBCORUM:3830PDB:5jqhPDB:6e6717363375

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry3387318684078452937922300
Sequence, Structure & Domains

Sequences

Length
413
Mass
46,459
Sequence
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

3D Structural Models

Turn
171..174; 238..240; 345..347
Helix
31..60; 62..64; 67..85; 87..96; 102..136; 147..170; 179..186; 197..207; 209..229; 267..298; 305..317; 318..320; 322..325; 326..328; 330..337
Beta Strand
25..27; 137..139; 140..142; 187..189; 299..303; 338..343; 355..357
3D Structure
Electron microscopy (95); NMR spectroscopy (1); X-ray crystallography (37)

Domain & Motif Annotations

Compositional Bias
393..413; Polar residues
Motif
410..413; PDZ-binding
Region
392..413; Disordered
Protein Families
  • G-protein coupled receptor 1 family
  • Adrenergic receptor subfamily
  • ADRB2 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Clinical Relevance
Related Diseases
AsthmaBladder disorderBreast cancerCachexiaCardiovascular diseaseChronic obstructive pulmonary diseaseConduction disorderDermal/subcutaneous connective tissue atrophy/degenerationEjaculatory dysfunctionHypertensionMelanomaObesityPreterm labour/deliverySkin and skin-structure infectionSleep-related breathing disorderStomach cancerSupraventricular tachyarrhythmia
Biomarker
Approved; Phase 1; Phase 3; Phase 2; Terminated; Discontinued in Preregistration; Phase 2/3
Drugs
VILANTEROLOT-730ANTIDEPRESSANT AGENTNADOLOLPROCATEROL HYDROCHLORIDEPINDOLOLPROCATEROLCARMOTEROLNULLBATEFENTEROLARFORMOTEROLBRONCHODILATORALPRENOLOLICI-118551CARTEOLOLDIENESTROLCLENBUTEROLPENBUTOLOLTIMOLOLBAMBUTEROLPF-00610355ENALAPRIL MALEATEBAMOSIRANLEVOBUNOLOLPROPAFENONE HYDROCHLORIDEBUPRANOLOLISOETHARINE MESYLATEOLODATEROL HYDROCHLORIDEABEDITEROLOXPRENOLOLNEBIVOLOL HYDROCHLORIDERITODRINEISOETHARINELAS190792EPINEPHRINECHEMBL:CHEMBL116548CHEMBL:CHEMBL579725METAPROTERENOLFENOTEROLTERTATOLOLCHEMBL:CHEMBL604311TERBUTALINE SULFATEESMOLOL HYDROCHLORIDEEPINEPHRINE BITARTRATECLOTRIMAZOLELABETALOLSALMETEROL XINAFOATECHEMBL:CHEMBL531401DISULFIRAMBITOLTEROL MESYLATERACEPINEPHRINE HYDROCHLORIDESODIUM CHLORIDEPENBUTOLOL SULFATEOXPRENOLOL HYDROCHLORIDEMETAPROTERENOL SULFATEBUNITROLOLSOTALOLBUCINDOLOL HYDROCHLORIDEBEDORADRINE SULFATETIMOLOL MALEATECHEMBL:CHEMBL590927PRONETALOLLEVALBUTEROL TARTRATEPHENYLEPHRINE HYDROCHLORIDETERBUTALINEISOETHARINE HYDROCHLORIDEMETIPRANOLOL HYDROCHLORIDEREPROTEROLCHEMBL:CHEMBL1256364METHACHOLINEISOXSUPRINE HYDROCHLORIDERAMIPRILALBUTEROL SULFATEPROPRANOLOL HYDROCHLORIDELY377604PRILOCAINE HYDROCHLORIDEFORMOTEROL FUMARATESALMETEROLINDACATEROLFENOTEROL HBRNOREPINEPHRINELEVALBUTEROLEPHEDRINEEPHEDRINE HYDROCHLORIDEISOPROTERENOLCARVEDILOLCARTEOLOL HYDROCHLORIDECHEMBL:CHEMBL12570923-O-METHYLQUERCETINPSEUDOEPHEDRINEVILANTEROL TRIFENATATERIMITEROLOLODATEROLROLIPRAMDILEVALOL HYDROCHLORIDEDESIPRAMINETULOBUTEROLGSK159802METIPRANOLOLNAVAFENTEROLPROTOKYLOL HYDROCHLORIDESOTALOL HYDROCHLORIDEDROXIDOPAGLYCOPYRRONIUMINDACATEROL MALEATEMEPINDOLOLNOREPINEPHRINE BITARTRATEISOPROTERENOL SULFATELABETALOL HYDROCHLORIDEMEPHENTERMINE SULFATECELIPROLOLCHEMBL:CHEMBL531322AZD3199VILANTEROL .ALPHA.-PHENYL CINNAMATERITODRINE HYDROCHLORIDETIOTROPIUMDICHLOROISOPROTERENOLCHEMBL:CHEMBL1465049CHEMBL:CHEMBL111201CLENBUTEROL HYDROCHLORIDEDIPIVEFRIN HYDROCHLORIDEMILVETEROLDOBUTAMINE HYDROCHLORIDECHEMBL:CHEMBL599896RISPERIDONEPIRBUTEROLHYDROXYAMPHETAMINE HYDROBROMIDEPIRBUTEROL ACETATE
Interaction Protein
ENSG00000074416ENSG00000109062ENSG00000113369ENSG00000141480ENSG00000165119ENSG00000171867ENSG00000197971
Interaction Count
7
Interaction Dataset
intact_biogrid