EV MemProt Atlas

Basic Information

Protein Names

Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)

Protein Function

Transporters
Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Small molecule drugs

Transmembrane

30..56; Helical; Name=1; 71..96; Helical; Name=2; 104..129; Helical; Name=3; 150..171; Helical; Name=4; 198..220; Helical; Name=5; 275..298; Helical; Name=6; 305..326; Helical; Name=7

Transmembrane Count

7

Ensembl

ENSG00000169252

Entrez Gene Symbol

ADRB2

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAdrenal medulla cellsBlood Cell SpecificbasophilSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway

Protein Function

Transporters
Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

63 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
ADRB2	PRKX	P51817	S	262	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PRKX	P51817	S	345	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PRKX	P51817	S	346	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PRKY	O43930	S	262	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PRKY	O43930	S	345	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PRKY	O43930	S	346	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	PDK1	Q15118	S	346	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	GRK4	P32298	S	355	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	GRK4	P32298	S	356	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
ADRB2	GRK1	Q15835	S	355	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	Cellinker	No	Yes	No	Yes	No

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Regulatory Interaction Network

16 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ADRB2	P07550	GNAS3	O95467	Yes	Yes	No	KEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17	BioGRID:12036966 Lit-BM-17:23798571 SIGNOR:31160049 Lit-BM-17:12036966 HINT:31740855 HINT:38480881 HINT:15782186 CA1:6149763 SIGNOR:14500986 HINT:32655881 Lit-BM-17:15782186
ADRB2	P07550	ALEX	P84996	Yes	Yes	No	KEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17	BioGRID:12036966 Lit-BM-17:23798571 SIGNOR:31160049 Lit-BM-17:12036966 HINT:31740855 HINT:38480881 HINT:15782186 CA1:6149763 SIGNOR:14500986 HINT:32655881 Lit-BM-17:15782186
ADRB2	P07550	GNAS2	P63092	Yes	Yes	No	KEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17	BioGRID:12036966 Lit-BM-17:23798571 SIGNOR:31160049 Lit-BM-17:12036966 HINT:31740855 HINT:38480881 HINT:15782186 CA1:6149763 SIGNOR:14500986 HINT:32655881 Lit-BM-17:15782186
ADRB2	P07550	GNAS1	Q5JWF2	Yes	Yes	No	KEGG-MEDICUSSIGNORHINTBioGRIDCA1WangLit-BM-17	BioGRID:12036966 Lit-BM-17:23798571 SIGNOR:31160049 Lit-BM-17:12036966 HINT:31740855 HINT:38480881 HINT:15782186 CA1:6149763 SIGNOR:14500986 HINT:32655881 Lit-BM-17:15782186
NHRF1	O14745	ADRB2	P07550	Yes	Yes	No	DOMINOWangSIGNORELMCui2007HINTHPRDBioGRIDCA1PDZBaseInnateDBLMPIDSPIKE_LCLit-BM-17	BioGRID:11882663 Lit-BM-17:9560162 LMPID:11882663 HPRD:9560162 CA1:11882663 BioGRID:9560162 DOMINO:9671706 LMPID:9671706 Lit-BM-17:9671706 HPRD:9671706 SIGNOR:9671706 Lit-BM-17:11882663 InnateDB:15452121 HINT:11882663 HINT:9560162 PDZBase:9671706 ELM:11882663 HINT:9671706 InnateDB:11882663 SPIKE_LC:9671706 LMPID:9560162 InnateDB:10499588 Lit-BM-17:11526121 HINT:10499588
KAPCA	P17612	ADRB2	P07550	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperCui2007CA1InnateDBWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:27481942 PhosphoSite:9461522 PhosphoSite:27646272 InnateDB:10753752 PhosphoSite:24003153 CA1:2987243 PhosphoSite:11146000
INSR	P06213	ADRB2	P07550	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEACellinkerSIGNOR_ProtMapperHPRD-phosNetworKIN_KEA	KEA:8557631 KEA:8521811 SIGNOR:8557631 Cellinker:28256297 KEA:8910597 ProtMapper:8557631 HPRD-phos:8557631 HPRD:8557631 KEA:17570479
AKT1	P31749	ADRB2	P07550	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:9032240 PhosphoSite:11809767 ProtMapper:11809767 SIGNOR:11809767
KPCD	Q05655	ADRB2	P07550	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	ProtMapper:1848190 HPRD-phos:1848190 SIGNOR:1848190 KEA:11809767 HPRD:1848190 KEA:11146000 KEA:8083204 KEA:1848190
GRK5	P34947	ADRB2	P07550	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMCellinkerSIGNOR_ProtMapper	phosphoELM:8662852 Cellinker:28431242 SIGNOR:8662852 HPRD:8662852 ProtMapper:9516468 HINT:8672451 KEA:96278816 KEA:8662852 ProtMapper:8662852 HINT:8662852

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Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ADRB2 homodimer complex	ADRB2	P07550	2	CORUMPDB	CORUM:3830PDB:5jqhPDB:6e67	17363375

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	3	38731868 40784529 37922300

Sequence, Structure & Domains

Sequences

Length

413

Mass

46,459

Sequence

MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

3D Structural Models

Turn

171..174; 238..240; 345..347

Helix

31..60; 62..64; 67..85; 87..96; 102..136; 147..170; 179..186; 197..207; 209..229; 267..298; 305..317; 318..320; 322..325; 326..328; 330..337

Beta Strand

25..27; 137..139; 140..142; 187..189; 299..303; 338..343; 355..357

3D Structure

Electron microscopy (95); NMR spectroscopy (1); X-ray crystallography (37)

Domain & Motif Annotations

Compositional Bias

393..413; Polar residues

Motif

410..413; PDZ-binding

Region

392..413; Disordered

Protein Families

G-protein coupled receptor 1 family
Adrenergic receptor subfamily
ADRB2 sub-subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Clinical Relevance

Related Diseases

Asthma Bladder disorder Breast cancer Cachexia Cardiovascular disease Chronic obstructive pulmonary disease Conduction disorder Dermal/subcutaneous connective tissue atrophy/degeneration Ejaculatory dysfunction Hypertension Melanoma Obesity Preterm labour/delivery Skin and skin-structure infection Sleep-related breathing disorder Stomach cancer Supraventricular tachyarrhythmia

Biomarker

Approved; Phase 1; Phase 3; Phase 2; Terminated; Discontinued in Preregistration; Phase 2/3

Drugs

VILANTEROL OT-730 ANTIDEPRESSANT AGENT NADOLOL PROCATEROL HYDROCHLORIDE PINDOLOL PROCATEROL CARMOTEROL NULL BATEFENTEROL ARFORMOTEROL BRONCHODILATOR ALPRENOLOL ICI-118551 CARTEOLOL DIENESTROL CLENBUTEROL PENBUTOLOL TIMOLOL BAMBUTEROL PF-00610355 ENALAPRIL MALEATE BAMOSIRAN LEVOBUNOLOL PROPAFENONE HYDROCHLORIDE BUPRANOLOL ISOETHARINE MESYLATE OLODATEROL HYDROCHLORIDE ABEDITEROL OXPRENOLOL NEBIVOLOL HYDROCHLORIDE RITODRINE ISOETHARINE LAS190792 EPINEPHRINE CHEMBL:CHEMBL116548 CHEMBL:CHEMBL579725 METAPROTERENOL FENOTEROL TERTATOLOL CHEMBL:CHEMBL604311 TERBUTALINE SULFATE ESMOLOL HYDROCHLORIDE EPINEPHRINE BITARTRATE CLOTRIMAZOLE LABETALOL SALMETEROL XINAFOATE CHEMBL:CHEMBL531401 DISULFIRAM BITOLTEROL MESYLATE RACEPINEPHRINE HYDROCHLORIDE SODIUM CHLORIDE PENBUTOLOL SULFATE OXPRENOLOL HYDROCHLORIDE METAPROTERENOL SULFATE BUNITROLOL SOTALOL BUCINDOLOL HYDROCHLORIDE BEDORADRINE SULFATE TIMOLOL MALEATE CHEMBL:CHEMBL590927 PRONETALOL LEVALBUTEROL TARTRATE PHENYLEPHRINE HYDROCHLORIDE TERBUTALINE ISOETHARINE HYDROCHLORIDE METIPRANOLOL HYDROCHLORIDE REPROTEROL CHEMBL:CHEMBL1256364 METHACHOLINE ISOXSUPRINE HYDROCHLORIDE RAMIPRIL ALBUTEROL SULFATE PROPRANOLOL HYDROCHLORIDE LY377604 PRILOCAINE HYDROCHLORIDE FORMOTEROL FUMARATE SALMETEROL INDACATEROL FENOTEROL HBR NOREPINEPHRINE LEVALBUTEROL EPHEDRINE EPHEDRINE HYDROCHLORIDE ISOPROTERENOL CARVEDILOL CARTEOLOL HYDROCHLORIDE CHEMBL:CHEMBL1257092 3-O-METHYLQUERCETIN PSEUDOEPHEDRINE VILANTEROL TRIFENATATE RIMITEROL OLODATEROL ROLIPRAM DILEVALOL HYDROCHLORIDE DESIPRAMINE TULOBUTEROL GSK159802 METIPRANOLOL NAVAFENTEROL PROTOKYLOL HYDROCHLORIDE SOTALOL HYDROCHLORIDE DROXIDOPA GLYCOPYRRONIUM INDACATEROL MALEATE MEPINDOLOL NOREPINEPHRINE BITARTRATE ISOPROTERENOL SULFATE LABETALOL HYDROCHLORIDE MEPHENTERMINE SULFATE CELIPROLOL CHEMBL:CHEMBL531322 AZD3199 VILANTEROL .ALPHA.-PHENYL CINNAMATE RITODRINE HYDROCHLORIDE TIOTROPIUM DICHLOROISOPROTERENOL CHEMBL:CHEMBL1465049 CHEMBL:CHEMBL111201 CLENBUTEROL HYDROCHLORIDE DIPIVEFRIN HYDROCHLORIDE MILVETEROL DOBUTAMINE HYDROCHLORIDE CHEMBL:CHEMBL599896 RISPERIDONE PIRBUTEROL HYDROXYAMPHETAMINE HYDROBROMIDE PIRBUTEROL ACETATE

Interaction Protein

ENSG00000074416ENSG00000109062ENSG00000113369ENSG00000141480ENSG00000165119ENSG00000171867ENSG00000197971

Interaction Count

7

Interaction Dataset

intact_biogrid

Protein symbol ADRB2	UniProt ID P07550	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification