Protein detail

CD3E

T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)

Protein symbol CD3E	UniProt ID P07766	EVMP score 0.50
Frequency 3	Transmembrane count 1	Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters

Basic Information

Protein Names

T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)

Protein Class

CD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsTransporters

Protein Function

CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Transporters:Accessory Factors Involved in Transport
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

127..152; Helical

Transmembrane Count

Ensembl

ENSG00000198851

Entrez Gene Symbol

CD3E

Gene Synonym

CD3-epsilonCD3epsilon

Gene Description

CD3 epsilon subunit of T-cell receptor complex

Chromosome

Position

118304730-118316175

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAdipocytes

Function & Pathway

Protein Function

CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Transporters:Accessory Factors Involved in Transport
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CD3E	LCK	P06239	Y	199	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:11855827 KEA:15659558 KEA:15144186 KEA:16094384 ProtMapper:11855827 KEA:15592455 HPRD:11855827 KEA:11855827 KEA:12522270
CD3E	LCK	P06239	Y	188	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	SIGNOR:11855827 KEA:15659558 KEA:16094384 ProtMapper:11855827 KEA:15592455 HPRD:11855827 KEA:11855827
CD3E	SRC	P12931	Y	188	phosphorylation	Li2012
CD3E	SRC	P12931	Y	199	phosphorylation	Li2012
CD3E	FYN	P06241	Y	199	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
CD3E	FYN	P06241	Y	188	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CD3G	P09693	CD3E	P07766	Yes	No	No	WangNetPathHPRDHINTSignaLink3SPIKE_LCSPIKETCRcuration_SignaLink3	SPIKE_LC:2138083 HINT:35271814 HINT:38657677 HINT:35985289 SignaLink3:23109003 HINT:20890284 NetPath:2138083 HINT:37100770 HPRD:2138083 SPIKE:2138083 HINT:2138083 SignaLink3:15084594 HINT:31461748
CD3E	P07766	NCK1	P16333	Yes	Yes	No	WangNetPathSIGNORELMHINTHPRDIntActLMPIDSPIKE_LCLit-BM-17SPIKE	SPIKE:12110186 IntAct:17617578 Lit-BM-17:12110186 SIGNOR:12110186 HINT:12110186 LMPID:17617578 IntAct:18955169 HPRD:12110186 ELM:18644376 HINT:17617578 Lit-BM-17:17617578 Lit-BM-17:18955169 SPIKE_LC:12110186 NetPath:12110186 ELM:17617578 HINT:18955169
CD3D	P04234	CD3E	P07766	Yes	No	No	NetPathHPRDHINTSignaLink3WangTCRcuration_SignaLink3	HINT:35271814 HPRD:9582308 HINT:38657677 HINT:35985289 SignaLink3:23109003 HINT:15534202 HINT:20890284 NetPath:2138083 HINT:37100770 HPRD:9485181 SignaLink3:15084594 HINT:31461748
LCK	P06239	CD3E	P07766	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007PhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	SIGNOR:11855827 KEA:15659558 SIGNOR:2470098 KEA:15144186 HPRD-phos:11855827 KEA:16094384 ProtMapper:11855827 KEA:15592455 HPRD:11855827 KEA:11855827 KEA:12522270
STML2	Q9UJZ1	CD3E	P07766	Yes	Yes	No	SIGNOR	SIGNOR:18641330
FYN	P06241	CD3E	P07766	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:15570572 PhosphoSite:17617578 PhosphoSite:20005895 PhosphoSite:32317279 PhosphoSite:16094384 PhosphoSite:18555270 PhosphoSite:15659558

Protein Complex Composition

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CD3D CD3E	P04234 P07766	2:2	PDB	PDB:1xiw
CD3E	P07766	2	PDB	PDB:8f0l
CD3E SCARA3	P07766 Q6AZY7	0:0	hu.MAP2
CD3E HS2ST1 IL20RB SCARA3	P07766 Q6AZY7 Q6UXL0 Q7LGA3	0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	30646616

Sequence, Structure & Domains

Sequences

Length

207

Mass

23,147

Sequence

MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI

3D Structural Models

Helix

24..26; 89..92; 105..107; 127..155; 193..195

Beta Strand

37..41; 44..48; 51..55; 57..61; 64..69; 75..78; 81..84; 94..100; 101..103; 110..116; 120..123

3D Structure

Electron microscopy (28); NMR spectroscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)

32..112; Ig-like; 178..205; ITAM

Region

161..207; Disordered; 175..192; NUMB-binding region; 179..186; Proline-rich sequence

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Breast cancer Melanoma Mycosis fungoides Prostate cancer Solid tumour/cancer Transplant rejection

Biomarker

Phase 2; Phase 1/2; Phase 1; Approved

Drug Targets

FDA approved drug targets

Antibody

CAB000010 HPA040957 HPA043955 CAB072863 CAB072864

Interaction Protein

ENSG00000071051ENSG00000131037ENSG00000158092

Interaction Count

Interaction Dataset

intact_biogrid