Protein detail
YES
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Entry name YES | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Protein Class
EnzymesFDA approved drug targetsPlasma proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
c-yesHsT441Yes
Gene Description
YES proto-oncogene 1, Src family tyrosine kinase
Chromosome
18
Position
721588-812546
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0001784 phosphotyrosine residue binding
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019899 enzyme binding
- GO:0044325 transmembrane transporter binding
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-389513 co inhibition by ctla4
- R-hsa-389356 co stimulation by cd28
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-9658195 leishmania infection
- R-hsa-9675108 nervous system development
- R-hsa-9664407 parasite infection
- R-hsa-210990 pecam1 interactions
- R-hsa-1433559 regulation of kit signaling
- R-hsa-912631 regulation of signaling by cbl
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8941326 runx2 regulates bone development
- R-hsa-8940973 runx2 regulates osteoblast differentiation
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-1227986 signaling by erbb2
- R-hsa-449147 signaling by interleukins
- R-hsa-9669938 signaling by kit in disease
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-1433557 signaling by scf kit
- R-hsa-8878166 transcriptional regulation by runx2
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
10 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| YES1 | CSK | P41240 | Y | 537 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:18083107dbPTM:18691976dbPTM:19369195dbPTM:15592455 |
| YES1 | CSK | P41240 | Y | 345 | phosphorylation | PhosphoNetworks | |
| YES1 | CSK | P41240 | Y | 426 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:16537894ProtMapper:11489946ProtMapper:14967142 |
| YES1 | CSK | P41240 | Y | 521 | phosphorylation | KEA | KEA:16439366 |
| YES1 | EPHA2 | P29317 | Y | 426 | phosphorylation | PhosphoSite | |
| YES1 | AXL | P30530 | Y | 426 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| YES1 | SOD3 | P08294 | Y | 426 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25751262 |
| YES1 | GNAI2 | P04899 | Y | 426 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11160627 |
| YES1 | PTK2B | Q14289 | Y | 426 | phosphorylation | NCI-PID_ProtMapperProtMapper | |
| YES1 | PTPN13 | Q12923 | Y | 426 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11983165 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| YES | P07947 | YAP1 | P46937 | Yes | Yes | No | Sparser_ProtMapperPhosphoPointSIGNORProtMapperREACH_ProtMapper | SIGNOR:23245941ProtMapper:30250159ProtMapper:33467099ProtMapper:23245941ProtMapper:29163769ProtMapper:32466572SIGNOR:35041461ProtMapper:24954536 |
| YES | P07947 | TYY1 | P25490 | Yes | No | Yes | SIGNOR | SIGNOR:26198631 |
| YES | P07947 | SOCS1 | O15524 | Yes | Yes | Yes | SIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:31101761 |
| YES | P07947 | LGUL | Q04760 | Yes | Yes | No | SIGNOR | SIGNOR:34838714 |
| YES | P07947 | ANXA2 | P07355 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | SIGNOR:33941853ProtMapper:33941853 |
| YES | P07947 | PO2F2 | P09086 | Yes | Yes | No | SIGNOR | SIGNOR:26979622 |
| UFO | P30530 | YES | P07947 | Yes | Yes | No | SIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:33941853 |
| IL6RB | P40189 | YES | P07947 | Yes | Yes | No | SIGNOR | SIGNOR:31296870 |
| YES | P07947 | WBP2 | Q969T9 | Yes | Yes | No | iPTMnetPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapper | SIGNOR:21642474 |
| RL10 | P27635 | YES | P07947 | Yes | No | Yes | DOMINOSIGNORHPRDHINTLit-BM-17 | HINT:16741966HPRD:12138090SIGNOR:12138090Lit-BM-17:16741966Lit-BM-17:12138090HINT:12138090 |
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Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FBLNOP56RPL10RPL11RPL13RPL13ARPL30RPS11RPS14RPS15ARPS17RPS4XRPS9UBCYES1 | O00567P07947P08708P0CG48P22087P26373P27635P40429P46781P62244P62263P62280P62701P62888P62913 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7037 | ||
| AATFFBLHNRNPMKRI1NOP14NOP56RPL10RPS11RPS13RPS4XRPS8RPS9UBCYES1 | O00567P07947P0CG48P22087P27635P46781P52272P62241P62277P62280P62701P78316Q8N9T8Q9NY61 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9787 | ||
| CCDC186TSNAXIP1YES1 | P07947Q2TAA8Q7Z3E2 | 0:0:0 | hu.MAP2 | |||
| CCDC186PIBF1TSNAXIP1VAT1LYES1 | P07947Q2TAA8Q7Z3E2Q8WXW3Q9HCJ6 | 0:0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 65 | 311969683168598433718342346223203640649137862381384411693893778939949490 308056063150850034108659382254533943621439873726412272964054596339940785327954143038291738731868228674562439373824733759258445992595038326801919268848412772398428242843289635522924238030353492305502873060870033709510342028553636211437926697390229904061999524468161273124283097589438151470384909584120109040344445379476023418624333023655283698482839651128476099307605383508558731320591412168843900170033905554403116164009145538136601304513714131576736332889 |
Sequence, Structure & Domains
Sequences
Length
543
Mass
60,801
Sequence
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
3D Structural Models
Turn
134..136
Helix
144..146
Beta Strand
93..100; 117..121; 126..133; 139..143; 147..149
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..20; Basic and acidic residues
Domain (FT)
91..152; SH3; 158..255; SH2; 277..530; Protein kinase
Region
1..45; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targetsProto-oncogene
Drug Targets
FDA approved drug targets
Drugs
CEDIRANIBGW290597XGW779439XREBASTINIBGW631581BCHEMBL:CHEMBL261440NAVITOCLAXGW441756XGW775608XMP-412PD173074GW827102XLENVATINIBGSK-466317ACHEMBL:CHEMBL102936GW612286XGSK-718429AGW856804XVEMURAFENIBCHEMBL:CHEMBL211045GW679410XMOTESANIBGW780056XALISERTIBCHEMBL:CHEMBL261129GW795486XGW801372XGW780159XSB203580SUNITINIBGSK-300014AREGORAFENIBDASATINIB ANHYDROUSGW279320XGW827396XPIOGLITAZONE HYDROCHLORIDEGW833373XGW621431XGSK-466314AGW805758XGW680191XVANDETANIBTG100-801ABT702PURVALANOL BCUDC-101GW300657XCHEMBL:CHEMBL1888586CHEMBL:CHEMBL275200BMS-509744GW572401XGW680975XSKF-86002AXITINIBGW621970XCHEMBL:CHEMBL103098GW580509XCHEMBL:CHEMBL95502CHEMBL:CHEMBL101804GW301888XBMS-777607CHEMBL:CHEMBL157258GW300660XSB220025SARACATINIBGW782612XCHEMBL:CHEMBL275168LINIFANIBGW810372XGW642138XGW561436XMITOXANTRONEGSK-1030061A(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEGSK-711701ACOMPOUND 27 [PMID: 24900635]CHEMBL:CHEMBL318892CHEMBL:CHEMBL269450DORSOMORPHINSB-633825BX-795AZ628CABOZANTINIB S-MALATEPD-0166285AZD-7762CHIR-265GSK-312948ACHEMBL:CHEMBL346551SGI-17765Z-7-OXOZEAENOLXL-228CHEMBL:CHEMBL260417AG14361ENMD-981693GW837331XGW784684XCHEMBL:CHEMBL408732TIVOZANIBMASITINIBGW785804XDOVITINIBGSK-1030062AGSK-1030058AGW809897XGSK-270822AILORASERTIBFORETINIBPAZOPANIBLAPATINIBGW703087XCHEMBL:CHEMBL352222GW828525XGW280670XGW513184XMOMELOTINIBGW711782XPICTILISIBCHEMBL:CHEMBL275724GW589933XGW874091XCHEMBL:CHEMBL329040GOSSYPOLGW581744XGW831091XCHEMBL:CHEMBL1785002NSC-663284GW643971XNVP-TAE684TOFACITINIBGW786460XCP-547632GSK-586581ARUCAPARIBJNJ-7706621CHEMBL:CHEMBL274863SEMAXANIBAT9283GSK-299115AADAVOSERTIBCLADRIBINEDORAMAPIMODCHEMBL:CHEMBL408564GSK-625137AGW829115XGSK-180736ASB202190TAMATINIBCANERTINIBCHEMBL:CHEMBL156263GSK-1000163ANERATINIBFALNIDAMOLGW682841XGW795493XJNJ-26483327PHA-793887CHEMBL:CHEMBL275798CHEMBL:CHEMBL399530GW829906XGW827106XGW305074XGW434756XGW819230XENTINOSTATGSK-1023156AGW852849XIMATINIBERLOTINIBCHEMBL:CHEMBL401570GW282974XGW827099XENMD-2076GW642125XGW876790XCHEMBL:CHEMBL103080SORAFENIBHESPERADINGW678313XQUERCETINCHEMBL:CHEMBL95207GW861893XIBRUTINIBTOZASERTIBGEFITINIBMIDOSTAURINAT-7519GW829055XCYC-116GW284372XGW627512BPLX-4720GW832467XGW559768XGSK-319347ACHEMBL:CHEMBL514554MLKL COMPOUND 1CHEMBL:CHEMBL160937GW819077XCHEMBL:CHEMBL237570PF-562271PONATINIBSILMITASERTIBGW831090XCHEMBL:CHEMBL407113GW301784XGW827105XCHEMBL:CHEMBL160333GW695874X
Interaction Protein
ENSG00000105401ENSG00000137312ENSG00000146648ENSG00000184221
Interaction Count
4
Interaction Dataset
intact_biogrid_bioplexbiogrid_bioplexintact_biogrid