Protein detail
LYN
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Entry name LYN | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Protein Class
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
JTK8
Gene Description
LYN proto-oncogene, Src family tyrosine kinase
Chromosome
8
Position
55879835-56014169
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0030061 mitochondrial crista
- GO:0030666 endocytic vesicle membrane
- GO:0034666 integrin alpha2-beta1 complex
- GO:0043231 intracellular membrane-bounded organelle
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0098978 glutamatergic synapse
- GO:0099091 postsynaptic specialization, intracellular component
Molecular Function
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0017124 SH3 domain binding
- GO:0019899 enzyme binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0043015 gamma-tubulin binding
- GO:0043208 glycosphingolipid binding
- GO:0044325 transmembrane transporter binding
- GO:0046875 ephrin receptor binding
- GO:0051219 phosphoprotein binding
- GO:0097110 scaffold protein binding
- GO:0140031 phosphorylation-dependent protein binding
- GO:0141038 phosphatidylinositol 3-kinase activator activity
KEGG
- hsa04062 Chemokine signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04662 B cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04730 Long-term depression
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05203 Viral carcinogenesis
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9918476 assembly and release of dengue virus virions
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5690714 cd22 mediated bcr regulation
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-389513 co inhibition by ctla4
- R-hsa-389356 co stimulation by cd28
- R-hsa-69231 cyclin d associated events in g1
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-5621480 dectin 2 family
- R-hsa-9839923 dengue virus infection
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-3928662 ephb mediated forward signaling
- R-hsa-3928665 eph ephrin mediated repulsion of cells
- R-hsa-2682334 eph ephrin signaling
- R-hsa-9027276 erythropoietin activates phosphoinositide 3 kinase pi3k
- R-hsa-9027277 erythropoietin activates phospholipase c gamma plcg
- R-hsa-9027284 erythropoietin activates ras
- R-hsa-9027283 erythropoietin activates stat5
- R-hsa-2871809 fceri mediated ca 2 mobilization
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2871837 fceri mediated nf kb activation
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-114604 gpvi mediated activation cascade
- R-hsa-982772 growth hormone receptor signaling
- R-hsa-109582 hemostasis
- R-hsa-9705462 inactivation of csf3 g csf signaling
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-9658195 leishmania infection
- R-hsa-453279 mitotic g1 phase and g1 s transition
- R-hsa-9675108 nervous system development
- R-hsa-9664407 parasite infection
- R-hsa-210990 pecam1 interactions
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-75892 platelet adhesion to exposed collagen
- R-hsa-1433559 regulation of kit signaling
- R-hsa-912631 regulation of signaling by cbl
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-2730905 role of lat2 ntal lab on calcium mobilization
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-9674555 signaling by csf3 g csf
- R-hsa-9006335 signaling by erythropoietin
- R-hsa-449147 signaling by interleukins
- R-hsa-9669938 signaling by kit in disease
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-1433557 signaling by scf kit
- R-hsa-983705 signaling by the b cell receptor bcr
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LYN | PTPN6 | P29350 | Y | 397 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15537644 |
| LYN | MATK | P42679 | Y | 508 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:1722201ProtMapper:9171348KEA:8612628HPRD:19651622HPRD:20068231HPRD:16497976HPRD:8612628HPRD:18691976HPRD:18669648KEA:9171348HPRD:19901323HPRD:18452278 |
| LYN | PTPRJ | Q12913 | Y | 508 | dephosphorylation | DEPOD | DEPOD:20345711 |
| LYN | CSNK1G2 | P78368 | S | 13 | phosphorylation | PhosphoSite | |
| LYN | CSNK1G1 | Q9HCP0 | S | 13 | phosphorylation | PhosphoSite | |
| LYN | CSNK1G3 | Q9Y6M4 | S | 13 | phosphorylation | PhosphoSite | |
| LYN | AXL | P30530 | Y | 397 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LYN | EGFR | P00533 | Y | 32 | phosphorylation | Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23764002ProtMapper:25071818 |
| LYN | SOD3 | P08294 | Y | 397 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25751262 |
| LYN | BCR | P11274 | Y | 397 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:24929000 |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
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Regulatory Interaction Network
82 records.
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PLC-gamma-2-SLP-76-Lyn-Grb2 complex | GRB2LCP2LYNPLCG2 | P07948P16885P62993Q13094 | 1:1:1:1 | CompleatCORUM | Compleat:HC3592CORUM:2536 | 10469124 |
| HOXB5LYNNDC1NUP155NUP188 | O75694P07948P09067Q5SRE5Q9BTX1 | 0:0:0:0:0 | hu.MAP2 | |||
| HOXB5HOXC4LYNNPRL3 | P07948P09017P09067Q12980 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains
Sequences
Length
512
Mass
58,574
Sequence
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=LYN A, p56lyn; IsoId=P07948-1; Sequence=Displayed; Name=2; Synonyms=LYN B, p53lyn; IsoId=P07948-2; Sequence=VSP_005002
Alternative Sequence
23..43; Missing (in isoform 2)
3D Structural Models
Turn
105..107; 267..269
Helix
115..117; 244..246; 284..296; 327..332; 334..338; 341..360; 370..372; 407..409; 412..417; 422..437; 449..457; 470..479; 484..486; 490..501
Beta Strand
67..72; 78..80; 89..96; 99..104; 110..114; 118..121; 247..255; 260..266; 270..277; 305..309; 311..320; 373..375; 381..383; 466..468
3D Structure
NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
The protein kinase domain plays an important role in its localization in the cell membrane.
Domain (FT)
63..123; SH3; 129..226; SH2; 247..501; Protein kinase
Region
1..62; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantProto-oncogene
Drugs
CENISERTIBBARASERTIB-HQPATG100-801TOZASERTIBGW441756XGO-6976LINIFANIBGW559768XSP-600125DOVITINIBNVP-TAE684MASITINIBENMD-981693BAFETINIBSB220025ILORASERTIBALSTERPAULLONECP-547632XL-228MLN-8054CEDIRANIBDASATINIB ANHYDROUSRG-1530NULLTOLIMIDONESORAFENIBERLOTINIBJNJ-26483327KENPAULLONEDORAMAPIMODTAMATINIBENTRECTINIBZIPRASIDONEBOSUTINIBCHEMBL:CHEMBL578061GEFITINIBIMATINIBCYC-116PF-562271GW459057AIBRUTINIB
Interaction Protein
ENSG00000012124ENSG00000076641ENSG00000088053ENSG00000110395ENSG00000111276ENSG00000121774ENSG00000146648ENSG00000153064ENSG00000169398ENSG00000197122
Interaction Count
10
Interaction Dataset
intact_biogrid