Protein detail
LYN
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Entry name LYN | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Protein Class (5)
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
JTK8
Gene Description
LYN proto-oncogene, Src family tyrosine kinase
Chromosome
8
Position
55879835-56014169
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component (17)
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0030061 mitochondrial crista
- GO:0030666 endocytic vesicle membrane
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Molecular Function (19)
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0017124 SH3 domain binding
- GO:0019899 enzyme binding
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KEGG (13)
- hsa04062 Chemokine signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04662 B cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04730 Long-term depression
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
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Reactome (59)
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9918476 assembly and release of dengue virus virions
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5690714 cd22 mediated bcr regulation
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-389513 co inhibition by ctla4
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence126
Enzyme-Mediated Modification (27)
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LYN | CSK | P41240 | Y | 508 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapper | KEA:1722201ProtMapper:22711887phosphoELM:9171348KEA:8612628HPRD:19651622HPRD:20068231HPRD:16497976HPRD:8612628KEA:10415030HPRD:18691976ProtMapper:15626731HPRD:18669648KEA:9171348HPRD:19901323HPRD:18452278 |
| LYN | CSK | P41240 | Y | 316 | phosphorylation | PhosphoNetworks | |
| LYN | CSK | P41240 | Y | 397 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:16537894ProtMapper:11489946ProtMapper:14967142 |
| LYN | PTPRC | P08575 | Y | 397 | dephosphorylation | HPRDSIGNOR | HPRD:10415030SIGNOR:10415030 |
| LYN | PTPRC | P08575 | Y | 508 | dephosphorylation | HPRD | HPRD:10415030 |
| LYN | PTPRC | P08575 | Y | 397 | phosphorylation | NCI-PID_ProtMapperSIGNOR_ProtMapperProtMapper | ProtMapper:7499277ProtMapper:10415030 |
| LYN | PTPRC | P08575 | Y | 508 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:10415030 |
| LYN | PTPRA | P18433 | Y | 397 | dephosphorylation | SIGNOR | SIGNOR:15537644 |
| LYN | PTPRA | P18433 | Y | 397 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:15537644 |
| LYN | PTPN6 | P29350 | Y | 397 | dephosphorylation | HPRDSIGNOR | HPRD:11042209SIGNOR:15537644 |
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Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
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Regulatory Interaction Network (82)
82 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | KPCD | Q05655 | Yes | Yes | Yes | WangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEASIGNOR_ProtMapper | KEA:15302935ProtMapper:30917487ProtMapper:10319993ProtMapper:10945993ProtMapper:7575560ProtMapper:11812791ProtMapper:9692543SIGNOR:9692543KEA:10945993KEA:96421649HPRD:10945993HPRD:7575560SIGNOR:11812791KEA:15774464KEA:7575560 |
| LYN | P07948 | PDIA3 | P30101 | Yes | No | No | SIGNORProtMapperphosphoELM_KEAKEASIGNOR_ProtMapper | KEA:8631326SIGNOR:8631326ProtMapper:8631326 |
| LYN | P07948 | LGUL | Q04760 | Yes | Yes | No | SIGNOR | SIGNOR:34838714 |
| LYN | P07948 | NEMO | Q9Y6K9 | Yes | No | Yes | REACH_ProtMapperSIGNORPhosphoSite_ProtMapperProtMapper | ProtMapper:23131831SIGNOR:23131831 |
| LYN | P07948 | KCND3 | Q9UK17 | Yes | Yes | No | SIGNOR | SIGNOR:22198508 |
| LYN | P07948 | NLRP3 | Q96P20 | Yes | No | Yes | SIGNORSparser_ProtMapperProtMapper | SIGNOR:34699250ProtMapper:33568399 |
| LYN | P07948 | SOCS1 | O15524 | Yes | No | Yes | SIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:31101761 |
| NEDD4 | P46934 | LYN | P07948 | Yes | No | Yes | SIGNOR | SIGNOR:10683340 |
| KC1G1 | Q9HCP0 | LYN | P07948 | Yes | Yes | No | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:33004926PhosphoSite:33004926 |
| LYN | P07948 | PP1R8 | Q12972 | Yes | No | Yes | HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite | HPRD:11104670dbPTM:11104670InnateDB:11104670ProtMapper:11104670phosphoELM:11104670KEA:11104670PhosphoSite:11104670SIGNOR:11104670 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PLC-gamma-2-SLP-76-Lyn-Grb2 complex | GRB2LCP2LYNPLCG2 | P07948P16885P62993Q13094 | 1:1:1:1 | CompleatCORUM | Compleat:HC3592CORUM:2536 | 10469124 |
| HOXB5LYNNDC1NUP155NUP188 | O75694P07948P09067Q5SRE5Q9BTX1 | 0:0:0:0:0 | hu.MAP2 | |||
| HOXB5HOXC4LYNNPRL3 | P07948P09017P09067Q12980 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains14
Sequences
Length
512
Mass
58,574
Sequence
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=LYN A, p56lyn; IsoId=P07948-1; Sequence=Displayed; Name=2; Synonyms=LYN B, p53lyn; IsoId=P07948-2; Sequence=VSP_005002
Alternative Sequence
23..43; Missing (in isoform 2)
3D Structural Models
Turn
105..107; 267..269
Helix
115..117; 244..246; 284..296; 327..332; 334..338; 341..360; 370..372; 407..409; 412..417; 422..437; 449..457; 470..479; 484..486; 490..501
Beta Strand
67..72; 78..80; 89..96; 99..104; 110..114; 118..121; 247..255; 260..266; 270..277; 305..309; 311..320; 373..375; 381..383; 466..468
3D Structure
NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
The protein kinase domain plays an important role in its localization in the cell membrane.
Domain (FT)
63..123; SH3; 129..226; SH2; 247..501; Protein kinase
Region
1..62; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance6
Disease Involvement (3)
Cancer-related genesDisease variantProto-oncogene
Drugs (41)
CENISERTIBBARASERTIB-HQPATG100-801TOZASERTIBGW441756XGO-6976LINIFANIBGW559768XSP-600125DOVITINIBNVP-TAE684MASITINIBENMD-981693BAFETINIBSB220025ILORASERTIBALSTERPAULLONECP-547632XL-228MLN-8054CEDIRANIBDASATINIB ANHYDROUSRG-1530NULLTOLIMIDONESORAFENIBERLOTINIBJNJ-26483327KENPAULLONEDORAMAPIMODTAMATINIBENTRECTINIBZIPRASIDONEBOSUTINIBCHEMBL:CHEMBL578061GEFITINIBIMATINIBCYC-116PF-562271GW459057AIBRUTINIB
Interaction Protein (10)
ENSG00000012124ENSG00000076641ENSG00000088053ENSG00000110395ENSG00000111276ENSG00000121774ENSG00000146648ENSG00000153064ENSG00000169398ENSG00000197122
Interaction Count
10
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38315424 | LRP10 and α-synuclein transmission in Lewy body diseases. | Here, we demonstrate that wild-type LRP10 is secreted via extracellular vesicles (EVs) and can be internalised via clathrin-dependent endocytosis. |