Protein detail
LYN
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Entry name LYN | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Protein Class (5)
Cancer-related genesDisease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
JTK8
Gene Description
LYN proto-oncogene, Src family tyrosine kinase
Chromosome
8
Position
55879835-56014169
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway6
Protein Function (7)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component (17)
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005765 lysosomal membrane
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0030061 mitochondrial crista
- GO:0030666 endocytic vesicle membrane
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Molecular Function (19)
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0017124 SH3 domain binding
- GO:0019899 enzyme binding
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KEGG (13)
- hsa04062 Chemokine signaling pathway
- KEGG:hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04662 B cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04730 Long-term depression
- KEGG:hsa05120 Epithelial cell signaling in Helicobacter pylori infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
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Reactome (59)
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9918476 assembly and release of dengue virus virions
- R-hsa-5621575 cd209 dc sign signaling
- R-hsa-5690714 cd22 mediated bcr regulation
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-389513 co inhibition by ctla4
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence126
Enzyme-Mediated Modification (27)
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LYN | EGF | P01133 | Y | 397 | phosphorylation | Sparser_ProtMapperProtMapper | |
| LYN | GNAI2 | P04899 | Y | 397 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11160627 |
| LYN | PTK2B | Q14289 | Y | 397 | phosphorylation | NCI-PID_ProtMapperProtMapper | |
| LYN | PTPN13 | Q12923 | Y | 397 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11983165 |
| LYN | IL6 | P05231 | Y | 397 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15626731 |
| LYN | IL6 | P05231 | Y | 508 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15626731 |
| LYN | JAK2 | O60674 | Y | 397 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19234487 |
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Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network (82)
82 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LYN | P07948 | FCG2A | P12318 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperReactome_ProtMapperHPRD-phos | phosphoELM:8756631HPRD:8756631KEA:8756631SIGNOR:8756631ProtMapper:8756631HPRD-phos:8756631InnateDB:9268059 |
| LYN | P07948 | LPXN | O60711 | Yes | Yes | No | AdhesomeiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperdbPTMKEAphosphoELM_KEASIGNOR_ProtMapper | dbPTM:17640867Adhesome:17640867KEA:17640867ProtMapper:17640867dbPTM:20543562SIGNOR:17640867 |
| LYN | P07948 | NMT1 | P30419 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperphosphoELMHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSite_ProtMapper | InnateDB:11594778ProtMapper:11594778phosphoELM:11594778HPRD:11594778SIGNOR:11594778KEA:11594778 |
| LYN | P07948 | FCG2C | P31995 | Yes | Yes | No | WangPhosphoNetworksiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper | phosphoELM:8756631SIGNOR:8756631KEA:8756631ProtMapper:8756631 |
| LYN | P07948 | LY96 | Q9Y6Y9 | Yes | No | No | PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:21918188 |
| LYN | P07948 | ABL1 | P00519 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperWangPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16787943ProtMapper:11847100ProtMapper:16076903PhosphoSite:12644574PhosphoSite:16912036 |
| LYN | P07948 | IKKB | O14920 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:12645577PhosphoSite:12707358PhosphoSite:26353931 |
| LYN | P07948 | AKAP8 | O43823 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:25770215 |
| LYN | P07948 | PTEN | P60484 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:11948419 |
| UFO | P30530 | LYN | P07948 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:20205385PhosphoSite:23764002 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PLC-gamma-2-SLP-76-Lyn-Grb2 complex | GRB2LCP2LYNPLCG2 | P07948P16885P62993Q13094 | 1:1:1:1 | CompleatCORUM | Compleat:HC3592CORUM:2536 | 10469124 |
| HOXB5LYNNDC1NUP155NUP188 | O75694P07948P09067Q5SRE5Q9BTX1 | 0:0:0:0:0 | hu.MAP2 | |||
| HOXB5HOXC4LYNNPRL3 | P07948P09017P09067Q12980 | 0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 30865381 |
Sequence, Structure & Domains14
Sequences
Length
512
Mass
58,574
Sequence
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=LYN A, p56lyn; IsoId=P07948-1; Sequence=Displayed; Name=2; Synonyms=LYN B, p53lyn; IsoId=P07948-2; Sequence=VSP_005002
Alternative Sequence
23..43; Missing (in isoform 2)
3D Structural Models
Turn
105..107; 267..269
Helix
115..117; 244..246; 284..296; 327..332; 334..338; 341..360; 370..372; 407..409; 412..417; 422..437; 449..457; 470..479; 484..486; 490..501
Beta Strand
67..72; 78..80; 89..96; 99..104; 110..114; 118..121; 247..255; 260..266; 270..277; 305..309; 311..320; 373..375; 381..383; 466..468
3D Structure
NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
The protein kinase domain plays an important role in its localization in the cell membrane.
Domain (FT)
63..123; SH3; 129..226; SH2; 247..501; Protein kinase
Region
1..62; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance6
Disease Involvement (3)
Cancer-related genesDisease variantProto-oncogene
Drugs (41)
CENISERTIBBARASERTIB-HQPATG100-801TOZASERTIBGW441756XGO-6976LINIFANIBGW559768XSP-600125DOVITINIBNVP-TAE684MASITINIBENMD-981693BAFETINIBSB220025ILORASERTIBALSTERPAULLONECP-547632XL-228MLN-8054CEDIRANIBDASATINIB ANHYDROUSRG-1530NULLTOLIMIDONESORAFENIBERLOTINIBJNJ-26483327KENPAULLONEDORAMAPIMODTAMATINIBENTRECTINIBZIPRASIDONEBOSUTINIBCHEMBL:CHEMBL578061GEFITINIBIMATINIBCYC-116PF-562271GW459057AIBRUTINIB
Interaction Protein (10)
ENSG00000012124ENSG00000076641ENSG00000088053ENSG00000110395ENSG00000111276ENSG00000121774ENSG00000146648ENSG00000153064ENSG00000169398ENSG00000197122
Interaction Count
10
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38315424 | LRP10 and α-synuclein transmission in Lewy body diseases. | Here, we demonstrate that wild-type LRP10 is secreted via extracellular vesicles (EVs) and can be internalised via clathrin-dependent endocytosis. |