Protein detail
TSP1
Thrombospondin-1 (Glycoprotein G)
Entry name TSP1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesCandidate cardiovascular disease genesPlasma proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Thrombospondin-1 (Glycoprotein G)
Protein Class (4)
Cancer-related genesCandidate cardiovascular disease genesPlasma proteinsPredicted secreted proteins
Protein Function (3)
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
THBSTHBS-1TSPTSP-1TSP1
Gene Description
Thrombospondin 1
Chromosome
15
Position
39581079-39599466
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecificlungCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (3)
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
Cellular Component (14)
- GO:0005576 extracellular region
- GO:0005577 fibrinogen complex
- GO:0005615 extracellular space
- GO:0005783 endoplasmic reticulum
- GO:0005788 endoplasmic reticulum lumen
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016529 sarcoplasmic reticulum
- GO:0030141 secretory granule
- GO:0031012 extracellular matrix
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Molecular Function (17)
- GO:0001786 phosphatidylserine binding
- GO:0001968 fibronectin binding
- GO:0002020 protease binding
- GO:0004866 endopeptidase inhibitor activity
- GO:0005178 integrin binding
- GO:0005201 extracellular matrix structural constituent
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008201 heparin binding
- GO:0017134 fibroblast growth factor binding
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Biological Process (3)
KEGG (15)
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04115 p53 signaling pathway
- KEGG:hsa04145 Phagosome
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04350 TGF-beta signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04820 Cytoskeleton in muscle cells
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Reactome (18)
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-5173214 o glycosylation of tsr domain containing proteins
- R-hsa-5173105 o linked glycosylation
- R-hsa-76002 platelet activation signaling and aggregation
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence47
Ligand-Receptor Signaling (39)
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ecm | ecm | CellChatDB | Yes | No | Yes | No | No |
| ecm | ecm | Cellinker | Yes | No | Yes | No | No |
| glycoprotein | ecm | Matrisome | Yes | No | Yes | No | No |
| ligand | ligand | talklr | Yes | No | Yes | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TSP1 | P07996 | NGF | P01138 | Yes | Yes | No | SIGNOR | SIGNOR:10708953 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Thrombospondin 1 complex | THBS1 | P07996 | 2 | ComplexPortalPDB | PDB:5foePDB:2ouhintact:EBI-2530370PDB:2es3 | 1475529215094115 |
| PDE7ATHBS1THBS3THBS4 | P07996P35443P49746Q13946 | 0:0:0:0 | hu.MAP | |||
| C5orf34IQSEC2PDE7ATHBS1THBS3THBS4 | P07996P35443P49746Q13946Q5JU85Q96MH7 | 0:0:0:0:0:0 | hu.MAP | |||
| IQSEC2THBS1THBS3THBS4 | P07996P35443P49746Q5JU85 | 0:0:0:0 | hu.MAP | |||
| FANCBTHBS1THBS3THBS4 | P07996P35443P49746Q8NB91 | 0:0:0:0 | hu.MAP | |||
| C5orf34THBS1THBS3THBS4 | P07996P35443P49746Q96MH7 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains16
Sequences
Length
1,170
Mass
129,383
Sequence
MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRDP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07996-1; Sequence=Displayed; Name=2; IsoId=P07996-2; Sequence=VSP_055757
Alternative Sequence
17..101; Missing (in isoform 2)
3D Structural Models
Turn
38..41; 123..126; 170..172; 203..205; 229..231; 408..410; 838..840; 854..856; 909..912; 941..943; 1087..1089; 1116..1119
Helix
33..37; 64..66; 72..85; 183..185; 191..194; 223..228; 869..871; 892..894; 905..907; 928..930; 1074..1081
Beta Strand
30..32; 44..49; 58..62; 87..96; 101..109; 115..122; 127..134; 137..145; 150..161; 164..169; 173..178; 195..200; 210..218; 394..403; 417..424; 450..459; 469..471; 478..485; 507..509; 511..516; 535..541; 849..852; 865..867; 888..890; 901..903; 924..926; 937..939; 961..965; 986..988; 995..1014; 1022..1031; 1034..1043; 1051..1053; 1059..1067; 1082..1084; 1090..1095; 1107..1115; 1120..1127; 1130..1134; 1146..1154; 1156..1167
3D Structure
X-ray crystallography (11)
Domain & Motif Annotations
Compositional Bias
840..854; Basic and acidic residues; 883..894; Basic and acidic residues; 917..934; Basic and acidic residues
Repeat
691..726; TSP type-3 1; 727..762; TSP type-3 2; 763..785; TSP type-3 3; 786..821; TSP type-3 4; 822..844; TSP type-3 5; 845..882; TSP type-3 6; 883..918; TSP type-3 7; 919..954; TSP type-3 8
Motif
926..928; Cell attachment site
Domain (FT)
65..270; Laminin G-like; 316..373; VWFC; 379..429; TSP type-1 1; 435..490; TSP type-1 2; 492..547; TSP type-1 3; 547..587; EGF-like 1; 646..690; EGF-like 2; 958..1170; TSP C-terminal
Region
47..95; Heparin-binding; 531..1152; Involved in retention in extracellular matrix (ECM); involved in trimer formation; 839..934; Disordered
Protein Families
Thrombospondin family
Sequence Similarities
Belongs to the thrombospondin family.
Clinical Relevance6
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 2
Drug Targets
Clinical trial target
Drugs (14)
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |