EV MemProt Atlas

Basic Information

Protein Names

Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Cancers:Cancers of soft tissues and bone
FDA approved drug targets:Biotech drugs

Transmembrane

936..959; Helical

Transmembrane Count

1

Ensembl

ENSG00000140443

Entrez Gene Symbol

IGF1R

Gene Synonym

CD221IGFIRIGFRJTK13MGC18216

Gene Description

Insulin like growth factor 1 receptor

Chromosome

15

Position

98648539-98964530

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteSecretome LocationSecreted to bloodSecretome FunctionNo annotated function

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of the digestive system
Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Cancers:Cancers of soft tissues and bone
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

19 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IGF1R	INSR	P06213	Y	1,166	phosphorylation	KEA	KEA:17570479
IGF1R	GRK6	P43250	S	1,321	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
IGF1R	GRK2	P25098	S	1,278	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
IGF1R	TP53	P04637	Y	1,161	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:19738076
IGF1R	IGF1	P05019	Y	1,161	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:19258508
IGF1R	IGF1	P05019	Y	1,166	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:23675206
IGF1R	IGF1	P05019	Y	1,165	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:23675206
IGF1R	FYN	P06241	Y	973	phosphorylation	KEA	KEA:17570479
IGF1R	FYN	P06241	Y	980	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	SignaLink_function	No	Yes	No	Yes	No
igf	receptor	Almen2009	No	Yes	No	Yes	No
kinase	receptor	Almen2009	No	Yes	No	Yes	No
receptor_tyrosine_kinases_rtk	receptor	HPMR	No	Yes	No	Yes	No
insulin_r	receptor	HPMR	No	Yes	No	Yes	No
kinase	receptor	Surfaceome	No	Yes	No	Yes	No
insr	receptor	Surfaceome	No	Yes	No	Yes	No
growth_factor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No

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Regulatory Interaction Network

33 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IGF1	P05019	IGF1R	P08069	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTSignaLink3UniProt_LRdbDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007CA1IntActDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	ProtMapper:19258508 SPIKE:1852007 connectomeDB2020:1852007 HINT:29483580 HINT:8452530 Cellinker:1852007 SIGNOR:19029956 IntAct:21645859 HINT:1852007 HINT:35660159 SignaLink3:1852007 IntAct:8452530 CA1:8408032 ICELLNET:2877871 DIP:11287679 SignaLink3:12067807 LRdb:2877871LRdb:185DIP:21645859 HPMR:2877871 ProtMapper:23675206 HINT:26027733 SignaLink3:23331499 HINT:21645859 SIGNOR:21798082 connectomeDB2020:2877871 CellTalkDB:2877871 ProtMapper:32849999 Cellinker:2877871 SignaLink3:21071413 CellChatDB:14604834 HPRD:1852007 SPIKE_LC:1852007 Cellinker:14604834 ICELLNET:1852007
IGF2	P01344	IGF1R	P08069	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTCellPhoneDB_CellinkerSignaLink3UniProt_LRdbCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerRamilowski2015CellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrCellinkerREACH_ProtMapperCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdbSPIKE	HINT:32459985 CellChatDB:14604834 SIGNOR:22810696 SignaLink3:11867533 SPIKE:20980691 LRdb:9972281 SPIKE_LC:20980691 CellTalkDB:9972281 Cellinker:9972281 ProtMapper:30231881 connectomeDB2020:9972281 SignaLink3:23331499 Cellinker:14604834 ICELLNET:9972281 HPRD:9972281 HINT:33961781
INS	P01308	IGF1R	P08069	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrICELLNETRamilowski2015SIGNORconnectomeDB2020HPRDHINTHPRD_talklrSignaLink3CellinkerWangLRdbCellCall	SIGNOR:1851182 SignaLink3:18988627 Cellinker:1851182 CellTalkDB:1851182 ICELLNET:1851182 SignaLink3:1851182 LRdb:1851182 HPRD:1851182 SignaLink3:23331499 connectomeDB2020:1851182 HINT:32275863
IGF1R	P08069	IRS4	O14654	Yes	Yes	No	PhosphoPointSIGNORHPRDHINTSignaLink3Wang	SignaLink3:18988627 SignaLink3:9553137 SignaLink3:11316748 SIGNOR:9553137 HINT:9553137 HINT:11316748 SignaLink3:23331499 HPRD:9553137 HPRD:11316748
NEDD4	P46934	IGF1R	P08069	Yes	Yes	Yes	HPRDWangSignaLink3	SignaLink3:18988627 SignaLink3:12697834 HPRD:12697834 SignaLink3:19165858 SignaLink3:23331499 SignaLink3:21071413
IGF1R	P08069	IRS1	P35568	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEASignaLink3phosphoELM_KEALi2012Lit-BM-17HPRDCui2007CA1LMPIDWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperACSNHPRD-phos	ACSN:12175651 KEA:12220227 SignaLink3:15629149 HINT:10026153 ProtMapper:8530377 HPRD:15629149 SIGNOR:15829723 ProtMapper:20670944 HINT:15629149 ACSN:10826997 HPRD:7559507 ProtMapper:25886138 HPRD:8530377 SIGNOR:17827393 HPRD-phos:8530377 SignaLink3:12220227 ACSN:21540285 Lit-BM-17:7541045 CA1:8776723 SignaLink3:8662806 ACSN:12444011 ACSN:16931767 KEA:8530377 SignaLink3:7559507 ProtMapper:17827393 HINT:8530377 SignaLink3:8776723 KEA:11572799 HINT:8776723 SignaLink3:18988627 ProtMapper:27856640 ACSN:12767520 HPRD:8662806 SignaLink3:8530377 KEA:7504175 ACSN:19030972 SignaLink3:23331499 Lit-BM-17:8776723 SIGNOR:21798082 Lit-BM-17:7559507 SignaLink3:21071413 LMPID:7541045 HINT:7541045 HINT:8662806 HPRD:12220227 PhosphoSite:8530377 LMPID:7537849 SignaLink3:11557037 KEA:11259577 Lit-BM-17:10082579 HINT:7559507 HINT:12220227 HINT:8895367 HINT:11694888 KEA:17570479
IGF1R	P08069	RASA1	P20936	Yes	Yes	No	HPRDWangPhosphoPointSignaLink3	SignaLink3:23331499 SignaLink3:18988627 HPRD:7642582 SignaLink3:7642582
IGF1R	P08069	IRS2	Q9Y4H2	Yes	Yes	No	PhosphoPointSIGNORHPRDHINTSignaLink3SPIKE_LC	HINT:8662806 HINT:9852124 SIGNOR:10471495 SPIKE_LC:8662806 HPRD:8662806 SignaLink3:10471495 HPRD:9852124 SignaLink3:23331499
PTN11	Q06124	IGF1R	P08069	Yes	Yes	No	HPRDHINTSignaLink3IntActWangLit-BM-17	IntAct:7642582 SignaLink3:10082579 Lit-BM-17:7642582 Lit-BM-17:10082579 SignaLink3:7642582 HINT:7642582 SignaLink3:11779860 HINT:28065597 Lit-BM-17:8895367 HPRD:7642582 HINT:8895367 IntAct:28065597 SignaLink3:23331499 IntAct:8895367
IGF1R	P08069	SHPS1	P78324	Yes	Yes	No	PhosphoSite_norefiPTMnetProtMapperSignaLink3PhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18233962 PhosphoSite:21799000 SignaLink3:11779860 PhosphoSite:10842184 SignaLink3:23331499

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Protein Complex Composition

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Shc-ERalpha-IGF-1R complex	ESR1 IGF1R SHC1	P03372 P08069 P29353	0:0:0	CORUM	CORUM:6251	14764897
	IGF1R INS	P01308 P08069	2:2	PDB	PDB:6jk8PDB:7v3p
	IGF1 IGF1R	P05019 P08069	2:2	PDB	PDB:5u8qPDB:7yrr
	IGF1R	P08069	3	PDB	PDB:3lvpPDB:7xgdPDB:1m7nPDB:3qquPDB:1p4oPDB:5hznPDB:7xlcPDB:8pyiPDB:3lw0PDB:1jqhPDB:2zm3PDB:3f5p
	HSP90B1 IGF1R IRS1 PIK3R3 UQCRC2 YWHAZ	P08069 P14625 P22695 P35568 P63104 Q92569	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6937
	FOXO1 HDAC4 IGF1R IRS1 MARK3 PIK3R3 TSC2 YWHAE YWHAG YWHAZ	P08069 P27448 P35568 P49815 P56524 P61981 P62258 P63104 Q12778 Q92569	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4618
	IGF1R IRS1	P08069 P35568	1:1	PDB	PDB:1k3a

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	R SequencingMass spectrometry	1	31382537

Sequence, Structure & Domains

Sequences

Length

1,367

Mass

154,793

Sequence

MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC

3D Structural Models

Turn

183..188; 272..274; 349..352; 415..417; 434..436; 469..471; 479..481; 662..664; 829..832; 844..846; 990..992; 1165..1167; 1212..1215; 1279..1281; 1283..1285

Helix

43..49; 96..98; 157..160; 164..166; 175..178; 217..219; 226..228; 279..283; 345..347; 375..378; 456..466; 517..519; 724..730; 810..813; 882..888; 933..960; 983..985; 996..998; 1041..1053; 1054..1056; 1087..1100; 1109..1128; 1138..1140; 1155..1157; 1159..1164; 1168..1170; 1176..1178; 1181..1186; 1191..1207; 1218..1226; 1239..1248; 1253..1255; 1259..1266; 1267..1269; 1274..1277

Beta Strand

37..41; 53..57; 59..65; 68..70; 80..83; 85..92; 115..121; 138..144; 150..152; 168..171; 194..199; 201..203; 205..209; 222..224; 235..241; 247..255; 257..263; 269..271; 275..277; 297..299; 302..306; 311..315; 321..323; 325..327; 331..341; 354..362; 383..386; 388..392; 397..399; 418..423; 440..443; 445..451; 452..454; 474..477; 482..485; 491..493; 495..500; 505..509; 520..529; 531..533; 543..546; 550..552; 565..568; 576..586; 591..593; 597..599; 602..605; 615..620; 626..632; 634..636; 644..650; 655..660; 777..782; 786..792; 798..805; 821..824; 839..843; 847..851; 862..873; 876..881; 889..893; 898..911; 920..924; 980..982; 999..1007; 1009..1022; 1025..1034; 1037..1039; 1065..1069; 1071..1074; 1076..1080; 1141..1143; 1149..1151; 1171..1174; 1286..1288

3D Structure

Electron microscopy (13); NMR spectroscopy (1); X-ray crystallography (31)

Domain & Motif Annotations

Compositional Bias

1290..1299; Acidic residues; 1300..1316; Low complexity; 1317..1326; Basic and acidic residues

Motif

977..980; IRS1- and SHC1-binding

Domain (FT)

491..609; Fibronectin type-III 1; 610..708; Fibronectin type-III 2; 735..828; Fibronectin type-III 3; 834..927; Fibronectin type-III 4; 999..1274; Protein kinase

Region

1288..1367; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Insulin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantFDA approved drug targets

Related Diseases

Adrenal cancer Breast cancer Chronic kidney disease Colorectal cancer Extraocular muscle disorder Liver cancer Lung cancer Motor neuron disease Multiple myeloma Multiple structural anomalies syndrome Pain Pancreatic cancer Parkinsonism Pituitary gland disorder Retinopathy Solid tumour/cancer Thyrotoxicosis

Biomarker

Discontinued in Phase 1; Phase 2; Phase 1; Approved; Phase 3

Drug Targets

FDA approved drug targets

Antibody

HPA004822 CAB010268 HPA045563

Interaction Protein

ENSG00000100614ENSG00000103653ENSG00000105647ENSG00000106070ENSG00000108953ENSG00000111679ENSG00000117461ENSG00000127022ENSG00000128228ENSG00000135679ENSG00000145675ENSG00000170027ENSG00000171105ENSG00000179295ENSG00000196396ENSG00000196914

Interaction Count

16

Interaction Dataset

intact_biogridbiogrid_opencellbiogrid_bioplex

Protein symbol IGF1R	UniProt ID P08069	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins