Protein detail
IGF1R
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Entry name IGF1R | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Protein Class (10)
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function (13)
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
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Transmembrane
936..959; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CD221IGFIRIGFRJTK13MGC18216
Gene Description
Insulin like growth factor 1 receptor
Chromosome
15
Position
98648539-98964530
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteSecretome LocationSecreted to bloodSecretome FunctionNo annotated function
Function & Pathway
Protein Function (13)
- Human disease related genes:Cancers:Cancers of the lung and pleura
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
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Cellular Component (11)
- GO:0005886 plasma membrane
- GO:0005899 insulin receptor complex
- GO:0005901 caveola
- GO:0016020 membrane
- GO:0030315 T-tubule
- GO:0030424 axon
- GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
- GO:0043025 neuronal cell body
- GO:0043231 intracellular membrane-bounded organelle
- GO:0043235 receptor complex
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Molecular Function (16)
- GO:0001965 G-protein alpha-subunit binding
- GO:0004713 protein tyrosine kinase activity
- GO:0005009 insulin receptor activity
- GO:0005010 insulin-like growth factor receptor activity
- GO:0005158 insulin receptor binding
- GO:0005198 structural molecule activity
- GO:0005515 protein binding
- GO:0005520 insulin-like growth factor binding
- GO:0005524 ATP binding
- GO:0031994 insulin-like growth factor I binding
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Biological Process (3)
KEGG (32)
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa01522 Endocrine resistance
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04140 Autophagy - animal
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Reactome (10)
- R-hsa-8939211 esr mediated signaling
- R-hsa-9009391 extra nuclear estrogen signaling
- R-hsa-5663205 infectious disease
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-2428933 shc related events triggered by igf1r
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-2404192 signaling by type 1 insulin like growth factor 1 receptor igf1r
- R-hsa-9824446 viral infection pathways
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence123
Enzyme-Mediated Modification (19)
19 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IGF1R | INSR | P06213 | Y | 1,166 | phosphorylation | KEA | KEA:17570479 |
| IGF1R | GRK6 | P43250 | S | 1,321 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| IGF1R | GRK2 | P25098 | S | 1,278 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| IGF1R | TP53 | P04637 | Y | 1,161 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:19738076 |
| IGF1R | IGF1 | P05019 | Y | 1,161 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:19258508 |
| IGF1R | IGF1 | P05019 | Y | 1,166 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:23675206 |
| IGF1R | IGF1 | P05019 | Y | 1,165 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:23675206 |
| IGF1R | FYN | P06241 | Y | 973 | phosphorylation | KEA | KEA:17570479 |
| IGF1R | FYN | P06241 | Y | 980 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (63)
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | connectomeDB2020 | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| receptor | receptor | talklr | Yes | Yes | |||
| receptor | receptor | Cellinker | Yes | Yes |
Regulatory Interaction Network (33)
33 records.
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Shc-ERalpha-IGF-1R complex | ESR1IGF1RSHC1 | P03372P08069P29353 | 0:0:0 | CORUM | CORUM:6251 | 14764897 |
| IGF1RINS | P01308P08069 | 2:2 | PDB | PDB:6jk8PDB:7v3p | ||
| IGF1IGF1R | P05019P08069 | 2:2 | PDB | PDB:5u8qPDB:7yrr | ||
| IGF1R | P08069 | 3 | PDB | PDB:3lvpPDB:7xgdPDB:1m7nPDB:3qquPDB:1p4oPDB:5hznPDB:7xlcPDB:8pyiPDB:3lw0PDB:1jqhPDB:2zm3PDB:3f5p | ||
| HSP90B1IGF1RIRS1PIK3R3UQCRC2YWHAZ | P08069P14625P22695P35568P63104Q92569 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6937 | ||
| FOXO1HDAC4IGF1RIRS1MARK3PIK3R3TSC2YWHAEYWHAGYWHAZ | P08069P27448P35568P49815P56524P61981P62258P63104Q12778Q92569 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4618 | ||
| IGF1RIRS1 | P08069P35568 | 1:1 | PDB | PDB:1k3a |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | R SequencingMass spectrometry | 1 | 31382537 |
Sequence, Structure & Domains
Sequences
Length
1,367
Mass
154,793
Sequence
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
3D Structural Models
Turn
183..188; 272..274; 349..352; 415..417; 434..436; 469..471; 479..481; 662..664; 829..832; 844..846; 990..992; 1165..1167; 1212..1215; 1279..1281; 1283..1285
Helix
43..49; 96..98; 157..160; 164..166; 175..178; 217..219; 226..228; 279..283; 345..347; 375..378; 456..466; 517..519; 724..730; 810..813; 882..888; 933..960; 983..985; 996..998; 1041..1053; 1054..1056; 1087..1100; 1109..1128; 1138..1140; 1155..1157; 1159..1164; 1168..1170; 1176..1178; 1181..1186; 1191..1207; 1218..1226; 1239..1248; 1253..1255; 1259..1266; 1267..1269; 1274..1277
Beta Strand
37..41; 53..57; 59..65; 68..70; 80..83; 85..92; 115..121; 138..144; 150..152; 168..171; 194..199; 201..203; 205..209; 222..224; 235..241; 247..255; 257..263; 269..271; 275..277; 297..299; 302..306; 311..315; 321..323; 325..327; 331..341; 354..362; 383..386; 388..392; 397..399; 418..423; 440..443; 445..451; 452..454; 474..477; 482..485; 491..493; 495..500; 505..509; 520..529; 531..533; 543..546; 550..552; 565..568; 576..586; 591..593; 597..599; 602..605; 615..620; 626..632; 634..636; 644..650; 655..660; 777..782; 786..792; 798..805; 821..824; 839..843; 847..851; 862..873; 876..881; 889..893; 898..911; 920..924; 980..982; 999..1007; 1009..1022; 1025..1034; 1037..1039; 1065..1069; 1071..1074; 1076..1080; 1141..1143; 1149..1151; 1171..1174; 1286..1288
3D Structure
Electron microscopy (13); NMR spectroscopy (1); X-ray crystallography (31)
Domain & Motif Annotations
Compositional Bias
1290..1299; Acidic residues; 1300..1316; Low complexity; 1317..1326; Basic and acidic residues
Motif
977..980; IRS1- and SHC1-binding
Domain (FT)
491..609; Fibronectin type-III 1; 610..708; Fibronectin type-III 2; 735..828; Fibronectin type-III 3; 834..927; Fibronectin type-III 4; 999..1274; Protein kinase
Region
1288..1367; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- Insulin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Clinical Relevance
Disease Involvement (3)
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases (17)
Biomarker
Discontinued in Phase 1; Phase 2; Phase 1; Approved; Phase 3
Drug Targets
FDA approved drug targets
Drugs (51)
CHEMBL:CHEMBL459729GANITUMABXL228NULLAEW-541BIIB-022KW-2450CIXUTUMUMABGEFITINIBPICROPODOPHYLLINMECASERMINFIGITUMUMABRINFABATESTAUROSPORINETEPROTUMUMAB-TRBWACETYLCYSTEINEGW441756XDALOTUZUMABLINSITINIBCENISERTIBCERITINIBPODOFILOXBMS-754807PD-0166285TAMOXIFENXL-228ISTIRATUMABROBATUMUMABPAZOPANIBTHROMBINTEPROTUMUMABMETFORMINANTI-IGF-1R RECOMBINANT MONOCLONAL ANTIBODY BIIB022MECASERMIN RINFABATEENTRECTINIBBMS-536924INSM-18ILORASERTIBCONTELTINIBRALOXIFENE HYDROCHLORIDEHESPERADINERLOTINIBTAMATINIBAVE-1642SB202190CRIZOTINIBEXEMESTANEPL-225BCHEMBL:CHEMBL546797PF-562271VELIGROTUG
Interaction Protein (16)
ENSG00000100614ENSG00000103653ENSG00000105647ENSG00000106070ENSG00000108953ENSG00000111679ENSG00000117461ENSG00000127022ENSG00000128228ENSG00000135679ENSG00000145675ENSG00000170027ENSG00000171105ENSG00000179295ENSG00000196396ENSG00000196914
Interaction Count
16
Interaction Dataset (3)
intact_biogridbiogrid_opencellbiogrid_bioplex
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |