Protein detail
TNR16
Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
Entry name TNR16 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
Protein Class (6)
Cancer-related genesCD markersPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- CD markers
- RAS pathway related proteins
- Cancer-related genes:Candidate cancer biomarkers
Transmembrane
251..272; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CD271p75NTRTNFRSF16
Gene Description
Nerve growth factor receptor
Chromosome
17
Position
49495293-49515008
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function (5)
- Transporters
- Predicted intracellular proteins
- CD markers
- RAS pathway related proteins
- Cancer-related genes:Candidate cancer biomarkers
Cellular Component (14)
- GO:0005576 extracellular region
- GO:0005654 nucleoplasm
- GO:0005768 endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0009986 cell surface
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030426 growth cone
Page 1 of 2
Molecular Function (11)
- GO:0001540 amyloid-beta binding
- GO:0004888 transmembrane signaling receptor activity
- GO:0005035 death receptor activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0015026 coreceptor activity
- GO:0031267 small GTPase binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0038023 signaling receptor activity
- GO:0043121 neurotrophin binding
Page 1 of 2
Biological Process (3)
KEGG (9)
- hsa03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04215 Apoptosis - multiple species
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa05202 Transcriptional misregulation in cancer
Reactome (12)
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-205025 nade modulates death signalling
- R-hsa-209560 nf kb is activated and signals survival
- R-hsa-193648 nrage signals death through jnk
- R-hsa-205043 nrif signals cell death from the nucleus
- R-hsa-193670 p75ntr negatively regulates cell cycle via sc1
- R-hsa-209543 p75ntr recruits signalling complexes
- R-hsa-193697 p75ntr regulates axonogenesis
- R-hsa-193639 p75ntr signals via nf kb
Page 1 of 2
Canonical Pathways
M117 Pid cone pathway
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence85
Enzyme-Mediated Modification (5)
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NGFR | PRKACB | P22694 | S | 303 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:12682012ProtMapper:12682012HPRD:12682012KEA:12682012 |
| NGFR | PRKCG | P05129 | S | 277 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| NGFR | PRKACA | P17612 | S | 303 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| NGFR | PRKX | P51817 | S | 303 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| NGFR | PRKY | O43930 | S | 303 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling (69)
69 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cytokine | receptor | iTALK | Yes | Yes | |||
| receptor | receptor | Almen2009 | Yes | Yes | |||
| receptor | receptor | CellCellInteractions | Yes | Yes | |||
| receptor | receptor | EMBRACE | Yes | Yes | |||
| tumor_necrosis_factor | receptor | HGNC | Yes | Yes | |||
| receptor | receptor | HGNC | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes | ||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | ||||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NGF | P01138 | TNR16 | P08138 | Yes | Yes | iTALKKirouac2010Guide2Pharma_LRdbSIGNORHINTDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020AlzPathwaySPIKE_LCLRdbSPIKE | AlzPathway:16893414Lit-BM-17:3037029HINT:11729324HINT:14985763Lit-BM-17:1372492DIP:1372492Lit-BM-17:14985763HPMR:11114882LRdb:11114882CellTalkDB:11114882LRdb:15Lit-BM-17:2172988SPIKE:15258592AlzPathway:9775403Cellinker:14985763Baccin2019:11114882Lit-BM-17:11729324HINT:3037029DIP:1714587Baccin2019:14985763SPIKE:14985763Cellinker:24224055Cellinker:11114882scConnect:22227462connectomeDB2020:14985763DIP:3037029DIP:2172988SIGNOR:14699954SPIKE_LC:14985763Lit-BM-17:1714587HPRD:14985763SPIKE_LC:15258592Guide2Pharma:22227462connectomeDB2020:11114882SIGNOR:10764727HINT:15131306 | |
| KAPCB | P22694 | TNR16 | P08138 | Yes | Yes | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSitePhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperLit-BM-17HPRD-phosPhosphoSite_ProtMapper | PhosphoSite:12682012HPRD-phos:12682012SIGNOR:12682012ProtMapper:12682012HPRD:12682012PhosphoSite:26119933Lit-BM-17:12682012KEA:12682012 | |
| KPCG | P05129 | TNR16 | P08138 | Yes | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19710323 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| NGF-p75 complex | NGFNGFR | P01138P08138 | 1:1 | CompleatCORUM | Compleat:HC432CORUM:5424 | 15131306 |
| Neurotrophin-3-p75 complex | NGFRNTF3 | P08138P20783 | 1:1 | CompleatCORUM | CORUM:5408Compleat:HC928 | 18596692 |
| NGFRRIPK2 | O43353P08138 | 1:1 | PDB | PDB:2n83 | ||
| NGFR | P08138 | 2 | PDB | PDB:5zggPDB:2n97 | ||
| CALM1NGFR | P08138P0DP23 | 1:1 | PDB | PDB:3ewv | ||
| ARHGDIANGFR | P08138P52565 | 1:1 | PDB | PDB:2n80PDB:8x8t | ||
| NGFRTRADD | P08138Q15628 | 1:1 | PDB | PDB:7csq |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
427
Mass
45,183
Sequence
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08138-1; Sequence=Displayed; Name=2; IsoId=P08138-2; Sequence=VSP_056850
Alternative Sequence
1..94; Missing (in isoform 2)
3D Structural Models
Turn
246..248; 301..303; 305..311; 418..420
Helix
252..276; 336..338; 341..351; 358..366; 370..377; 382..390; 398..409; 411..417
Beta Strand
289..291; 296..298; 314..317; 354..356; 379..381; 421..423
3D Structure
NMR spectroscopy (6); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
197..214; Polar residues; 281..291; Polar residues; 305..326; Polar residues
Repeat
31..64; TNFR-Cys 1; 66..107; TNFR-Cys 2; 108..146; TNFR-Cys 3; 148..188; TNFR-Cys 4
Domain (CC)
The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).; DOMAIN: The extracellular domain is responsible for interaction with NTRK1..
Domain (FT)
344..421; Death
Region
194..219; Disordered; 281..338; Disordered; 326..341; Mediates interaction with KIDINS220
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases (12)
Biomarker
Phase 1/2; Investigative; Phase 3; Terminated; Discontinued in Phase 3; Approved; Phase 2
Drugs (3)
Interaction Protein (3)
ENSG00000134259ENSG00000142192ENSG00000165821
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |