Protein detail
DAF
Complement decay-accelerating factor (CD antigen CD55)
Entry name DAF | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 34 | Transmembrane count | Protein classification Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Complement decay-accelerating factor (CD antigen CD55)
Protein Class (8)
Blood group antigen proteinsCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function (6)
- Predicted intracellular proteins
- Blood group antigen proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CRCROMDAFTC
Gene Description
CD55 molecule (Cromer blood group)
Chromosome
1
Position
207321519-207386804
Supporting publications (n)
34
EVMP confidence score
0.63
Fluorescence & Localization1
Cell SpecificAlveolar cells type 1
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- Blood group antigen proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Disease related genes
Cellular Component (11)
- GO:0000139 Golgi membrane
- GO:0005576 extracellular region
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0030133 transport vesicle
- GO:0030667 secretory granule membrane
- GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
- GO:0045121 membrane raft
- GO:0070062 extracellular exosome
- GO:0098552 side of membrane
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Molecular Function (3)
Biological Process (3)
KEGG (3)
Reactome (13)
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-166658 complement cascade
- R-hsa-6807878 copi mediated anterograde transport
- R-hsa-199977 er to golgi anterograde transport
- R-hsa-500792 gpcr ligand binding
- R-hsa-168249 innate immune system
- R-hsa-199991 membrane trafficking
- R-hsa-6798695 neutrophil degranulation
- R-hsa-597592 post translational protein modification
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Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence42
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | Yes |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | Yes |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | Yes |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | Yes |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | Yes |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | Yes |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | Yes |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | Yes | Yes | Yes |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | Yes | Yes | Yes |
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Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DAF | P08174 | AGRE5 | P48960 | Yes | Yes | No | iTALKSIGNORHINTCellPhoneDB_CellinkerHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | HINT:11297558connectomeDB2020:10540231SIGNOR:12417446Cellinker:10540231Cellinker:12417446LRdb:12417446HINT:33992645LRdb:11HPRD:10540231CellTalkDB:12417446connectomeDB2020:12417446CellChatDB:31462748HPMR:12417446 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass Spectrometry | 1 | 38037300 |
Sequence, Structure & Domains15
Sequences
Length
381
Mass
41,400
Sequence
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=2; Synonyms=DAF-2; IsoId=P08174-1; Sequence=Displayed; Name=1; Synonyms=DAF-1; IsoId=P08174-2; Sequence=VSP_001200; Name=3; Synonyms=VDAF3; IsoId=P08174-3; Sequence=VSP_047636; Name=4; Synonyms=VDAF2; IsoId=P08174-4; Sequence=VSP_047637; Name=5; Synonyms=VDAF1; IsoId=P08174-5; Sequence=VSP_047638; Name=6; Synonyms=VDAF4; IsoId=P08174-6; Sequence=VSP_047635; Name=7; Synonyms=VDAF5; IsoId=P08174-7; Sequence=VSP_047634
Alternative Sequence
326; Q -> QGTETPSVLQKHTTENVSATRTPPTPQKPTTVNVPATIVTPTPQKPTTINVPATGVSSTPQRHTIVNVSATGTLPTLQKPTRANDSATKSPAAAQTSFISKTLSTKTPSAAQNPMMTNASATQATLTAQKFTTAKVAFTQSPSAARKSTNVHSPVTNGLKSTQRFPSAHIT (in isoform 7); 327; A -> GTETPSVLQKHTTENVSATRTPPTPQKPTTVNVPATIVTPTPQKPTTINVPATGVSSTPQRHTIVNVSATGTLPTLQKPTRANDSATKSPAAAQTSFISKTLSTKTPSAAQNPMMTNASATQATLTAQKFTTAKVAFTQSPSAAP (in isoform 6); 361..381; GHTCFTLTGLLGTLVTMGLLT -> ALQVRPFEVSGSSHISSKKMMCIL (in isoform 3); 361..381; GHTCFTLTGLLGTLVTMGLLT -> VLFM (in isoform 4); 361..381; GHTCFTLTGLLGTLVTMGLLT -> ETVFHRVIQDGLDLLASRSACLGLPKCWDYRREPPHLARAHVFHVDRFAWDASNHGLADLAKEELRRKYTQVYRLFLVS (in isoform 5); 362..381; HTCFTLTGLLGTLVTMGLLT -> SRPVTQAGMRWCDRSSLQSRTPGFKRSFHFSLPSSWYYRAHVFHVDRFAWDASNHGLADLAKEELRRKYTQVYRLFLVS (in isoform 1)
3D Structural Models
Turn
83..85; 177..180
Helix
113..115
Beta Strand
45..47; 60..65; 69..71; 78..82; 94..98; 105..109; 124..129; 133..135; 137..139; 142..145; 149..151; 157..160; 172..175; 185..190; 194..198; 200..207; 210..215; 219..222; 234..236; 241..244; 248..253; 258..261; 263..270; 273..278; 282..284
3D Structure
Electron microscopy (18); NMR spectroscopy (1); X-ray crystallography (14)
Domain & Motif Annotations
Compositional Bias
287..309; Polar residues; 310..328; Low complexity
Domain (CC)
The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
Domain (FT)
35..96; Sushi 1; 96..160; Sushi 2; 161..222; Sushi 3; 223..285; Sushi 4
Region
277..354; Disordered
Protein Families
Receptors of complement activation (RCA) family
Sequence Similarities
Belongs to the receptors of complement activation (RCA) family.
Clinical Relevance6
Disease Involvement
Disease variant
Related Diseases (7)
Biomarker
Phase 1/2; Phase 2; Discontinued in Phase 1
Drug Targets
Clinical trial target
Supporting Publications31
| PMID | Title | Abstract |
|---|---|---|
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No abstract available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 29436780 | Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells. | No abstract available |
| 30408591 | Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32056672 | Proteomics profiling of epithelium-derived exosomes from nasal polyps revealed signaling functions affecting cellular proliferation. | No abstract available |
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