Protein detail

MDR1

ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243)

Protein symbol MDR1	UniProt ID P08183	EVMP score 0.50
Frequency 1	Transmembrane count 12	Protein classification Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
ENZYME proteins
Transporters:Primary Active Transporters
Disease related genes

Transmembrane

45..67; Helical; 117..137; Helical; 187..208; Helical; 216..236; Helical; 293..316; Helical; 331..352; Helical; 712..732; Helical; 757..777; Helical; 833..853; Helical; 855..874; Helical; 935..957; Helical; 974..995; Helical

Transmembrane Count

Ensembl

ENSG00000085563

Entrez Gene Symbol

ABCB1

Gene Synonym

ABC20CD243CLCSGP170MDR1p-170P-gpPGY1

Gene Description

ATP binding cassette subfamily B member 1

Chromosome

Position

87503017-87713323

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Immune system diseases:Other immune system diseases
Predicted intracellular proteins
CD markers
Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Enzymes
Cancer-related genes:Candidate cancer biomarkers
ENZYME proteins
Transporters:Primary Active Transporters
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

24 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ABCB1	PRKACA	P17612	S	683	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:94220047 KEA:7909431
ABCB1	PRKACA	P17612	S	667	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABCB1	PRKACA	P17612	S	671	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ABCB1	PRKCA	P17252	S	661	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:17570479
ABCB1	PRKCA	P17252	S	667	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:17570479
ABCB1	PRKCA	P17252	S	671	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:17570479
ABCB1	PRKCA	P17252	S	683	phosphorylation	KEA	KEA:17570479
ABCB1	PRKCB	P05771	S	661	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ABCB1	PRKCB	P05771	S	667	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
ABCB1	PRKCB	P05771	S	671	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transporter	transporter	Surfaceome	No	Yes	No	Yes	No
abc	transporter	DGIdb	No	Yes	No	Yes	No
transporter	transporter	DGIdb	No	Yes	No	Yes	No
active	transporter	Surfaceome	No	Yes	No	Yes	No
abcb	transporter	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:P62877_P63208_Q13616	MDR1	P08183	Yes	No	Yes	SIGNOR	SIGNOR:26299618
PIM1	P11309	MDR1	P08183	Yes	Yes	No	SIGNORSparser_ProtMapperProtMapper	ProtMapper:32195185 SIGNOR:24333728 ProtMapper:24333728
FBX21	O94952	MDR1	P08183	Yes	No	Yes	SIGNOR	SIGNOR:26299618
PPP5	P53041	MDR1	P08183	Yes	No	Yes	SIGNOR	SIGNOR:24333728
KPCA	P17252	MDR1	P08183	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperKEAPhosphoSiteNetworKIN_KEA	KEA:17570479 PhosphoSite:7909431 iPTMnet:7909431

Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ABCB1-PPP2R3C-TFPI2 complex	ABCB1 PPP2R3C TFPI2	P08183 P48307 Q969Q6	0:0:0	CORUM	CORUM:7256	24333728
ABCB10-ABCB7-FECH ABC transporter	ABCB10 ABCB7 FECH	O75027 P22830 Q9NRK6	2:2:2	ComplexPortal	intact:EBI-46449780	30765471 14755292
	ABCB1 BCCIP DPYD RPL23 SETD3 UBC	P08183 P0CG48 P62829 Q12882 Q86TU7 Q9P287	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6715
	ABCB10 CEACAM21 RYK	P34925 Q3KPI0 Q9NRK6	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 41068253

Sequence, Structure & Domains

Sequences

Length

1,280

Mass

141,479

Sequence

MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08183-1; Sequence=Displayed; Name=2; IsoId=P08183-2; Sequence=VSP_055769

Alternative Sequence

113..177; RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD -> S (in isoform 2)

3D Structural Models

Turn

160..162; 507..510; 519..521; 590..594; 889..893; 1101..1103

Helix

38..40; 45..62; 64..88; 107..154; 168..170; 173..186; 188..210; 212..219; 222..237; 239..246; 248..258; 261..267; 270..322; 328..347; 350..370; 433..440; 458..460; 463..468; 484..489; 497..506; 511..515; 526..528; 533..545; 563..573; 612..618; 621..629; 697..701; 702..707; 708..722; 724..737; 738..740; 745..797; 801..805; 811..819; 821..824; 825..828; 830..853; 855..862; 865..879; 894..899; 904..910; 914..923; 925..965; 971..992; 998..1013; 1078..1083; 1106..1112; 1128..1131; 1142..1151; 1155..1159; 1164..1166; 1171..1173; 1178..1190; 1208..1222; 1235..1238; 1257..1262; 1266..1271

Beta Strand

377..379; 392..398; 402..404; 410..412; 415..417; 422..426; 447..457; 470..473; 481..483; 516..518; 550..556; 559..561; 578..585; 595..602; 605..608; 741..743; 806..808; 1035..1041; 1045..1047; 1048..1052; 1056..1060; 1066..1069; 1074..1077; 1090..1096; 1114..1116; 1124..1126; 1161..1163; 1195..1201; 1225..1230; 1240..1247; 1250..1256; 1272..1274

3D Structure

Electron microscopy (24)

Domain & Motif Annotations

Compositional Bias

662..672; Basic residues

Domain (FT)

51..357; ABC transmembrane type-1 1; 392..628; ABC transporter 1; 711..1000; ABC transmembrane type-1 2; 1035..1273; ABC transporter 2

Region

646..685; Disordered

Protein Families

ABC transporter superfamily
ABCB family
Multidrug resistance exporter (TC 3.A.1.201) subfamily

Sequence Similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variant

Related Diseases

Acute myeloid leukaemia Adrenal cancer Bacterial infection Lung cancer Ovarian cancer Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Discontinued in Phase 2; Phase 1

Drug Targets

Clinical trial target

Drugs

ANTICONVULSANT AGENT TARIQUIDAR ROCURONIUM NULL NIFEDIPINE EPIPODOPHYLLOTOXIN COMPOUND BEPRIDIL IDARUBICIN CARVEDILOL PACLITAXEL SIMVASTATIN RESERPINE CARBOPLATIN FLUOROURACIL ADRIAMYCIN PRAVASTATIN SODIUM GEFITINIB RO 31-8220 PENTAZOCINE PROPAFENONE SPIRONOLACTONE RITUXIMAB PROPRANOLOL HYDROCHLORIDE IMATINIB KETOCONAZOLE ENCEQUIDAR BIRICODAR BAFETINIB ONDANSETRON HYDROCHLORIDE CHEMBL:CHEMBL217425 CHEMBL:CHEMBL533293 ITRACONAZOLE DOMPERIDONE NICOTINE POLACRILEX FEXOFENADINE HYDROCHLORIDE TETRABENAZINE DILTIAZEM HYDROCHLORIDE GABAPENTIN COLCHICINE MEGESTROL ACETATE NEVIRAPINE SIROLIMUS TRICHOSTATIN A RANITIDINE HYDROCHLORIDE EPOTHILONE D ATAZANAVIR LITHIUM METHYLPHENIDATE HYDROCHLORIDE GRAPEFRUIT JUICE DOXYCYCLINE ANHYDROUS NAPROXEN SODIUM IBUPROFEN, SODIUM SALT PROGESTERONE FLUVOXAMINE HYDROCORTISONE BUTYRATE NIMODIPINE CODEINE ANHYDROUS DIHYDRO-12-HYDROXY-2,2-DIMETHYL-2H,6H-PYRANO[3,2-B]XANTHEN-6-ONE BROMOCRIPTINE DEXTROMETHORPHAN POLISTIREX DAPTOMYCIN ELACRIDAR ACETAMINOPHEN QUINIDINE TENIPOSIDE SAQUINAVIR ANTIFUNGAL AGENT CELIPROLOL VEMURAFENIB ATENOLOL DESIPRAMINE OMEPRAZOLE PYRAZINAMIDE SPARFLOXACIN OXCARBAZEPINE LANIQUIDAR TESMILIFENE TRIMETREXATE CURCUMIN LOVASTATIN MILTIRONE VINBLASTINE PROBENECID AMISULPRIDE INDINAVIR FELODIPINE NELFINAVIR METOCHALCONE PURGIN II 1,4-BENZOQUINONE MEFLOQUINE CERITINIB AZATHIOPRINE PEGINTERFERON ALFA-2A HETEROCODEINE 2',4'-DIHYDROXYCHALCONE ATORVASTATIN CALCIUM TRIHYDRATE BRYOSTATIN 1 ANTIPARASITIC AGENT CAPSAICIN DEFEROXAMINE IL-3 LENOGRASTIM NEFAZODONE PALIPERIDONE ALDOSTERONE DIGOXIN DISULFIRAM CYCLOSPORINE LOPINAVIR EFAVIRENZ VINCA ALKALOID COMPOUND QUERCETIN-3'-O-PHOSPHATE CHEMBL:CHEMBL306786 CHEMBL:CHEMBL595816 MILTEFOSINE TETRACYCLINE H2O2 CHEMBL:CHEMBL203365 DOXORUBICIN HYDROCHLORIDE PHENOBARBITAL CAELYX PLATINUM THERAPEUTIC CORTICOSTEROID GRAMICIDIN LEVETIRACETAM TOPOTECAN HYDROCHLORIDE VITAMIN E 3,4-DIHYDROXYXANTHONE BRECANAVIR TERFENADINE BISANTRENE ZOSUQUIDAR PERVILLEINE B RITONAVIR CHEMBL:CHEMBL444075 FLAVOKAWAIN A DELAVIRDINE EPIRUBICIN GREEN TEA EXTRACT DIMETHYL SULFOXIDE HISTONE DEACETYLASE INHIBITOR CABAZITAXEL MONOAMINE OXIDASE INHIBITOR LIOTHYRONINE LEVOFLOXACIN ANHYDROUS METHADONE HYDROCHLORIDE CIMETIDINE MODAFINIL ASTEMIZOLE MELPHALAN SCUTELLARIN FLUPENTHIXOL MURUCOIDIN V PERVILLEINE D RASAGILINE CAMPTOTHECIN ANTHRACYCLINE ANTINEOPLASTIC ANTIBIOTIC FOLATE ANTAGONIST CHLORPROMAZINE LONAFARNIB GINKGO BILOBA EXTRACT BOCEPREVIR ALISKIREN AMPRENAVIR CRIZOTINIB VERAPAMIL 2'-HYDROXYCHALCONE NITRENDIPINE TAXOL C TANGERETIN CHEMBL:CHEMBL408422 MITOMYCIN RANOLAZINE PREDNISONE CHEMBL:CHEMBL270688 PERVILLEINE F DAUNORUBICIN LIPOSOMAL MARIJUANA MAPROTILINE ERYTHROMYCIN SORAFENIB CHEMBL:CHEMBL410907 VINDESINE VALSPODAR MIFEPRISTONE DENDROAMIDE A DOXEPIN HYDROCHLORIDE BROMPERIDOL TRABECTEDIN ROMIDEPSIN FLUVASTATIN IGURATIMOD AZITHROMYCIN PERVILLEINE C VINCRISTINE IVERMECTIN CLARITHROMYCIN HYDROXOCOBALAMIN ERLOTINIB VORICONAZOLE VALINOMYCIN DRONABINOL PAREGORIC ETRAVIRINE ZIDOVUDINE MICONAZOLE NITRATE PHENOTHIAZINE GARLIC IL-6 SILIBININ FOLIC ACID FLUPHENAZINE HYDROCHLORIDE AMIODARONE HYDROCHLORIDE LANSOPRAZOLE GEMTUZUMAB OZOGAMICIN DASATINIB ANHYDROUS MITOXANTRONE AUSTOCYSTIN D BIOCHANIN A FENOFIBRATE MICRONIZED ASPIRIN NICARDIPINE AMLODIPINE BESYLATE RIFAMPIN QUININE CREMOPHOR EL NABIXIMOLS VECURONIUM BROMIDE CLOMIPRAMINE METHYLPREDNISOLONE MDR MODULATOR CBT-1 VOACAMINE VITAMIN B12 ABEMACICLIB

Antibody

CAB001716 HPA002199 HPA074614

Interaction Protein

ENSG00000103769

Interaction Count

Interaction Dataset

biogrid_opencell