Protein detail
HS90B
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Entry name HS90B | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function (5)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
HSPC2HSPCB
Gene Description
Heat shock protein 90 alpha family class B member 1
Chromosome
6
Position
44246166-44253888
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificOligodendrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function (5)
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
Cellular Component (23)
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0008180 COP9 signalosome
- GO:0009986 cell surface
- GO:0016020 membrane
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Molecular Function (28)
- GO:0003723 RNA binding
- GO:0003725 double-stranded RNA binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0019887 protein kinase regulator activity
- GO:0019900 kinase binding
- GO:0019901 protein kinase binding
- GO:0023026 MHC class II protein complex binding
- GO:0030235 nitric-oxide synthase regulator activity
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Biological Process (3)
KEGG (15)
- hsa04141 Protein processing in endoplasmic reticulum
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04612 Antigen processing and presentation
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04657 IL-17 signaling pathway
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04914 Progesterone-mediated oocyte maturation
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa05132 Salmonella infection
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Reactome (49)
- R-hsa-8937144 aryl hydrocarbon receptor signalling
- R-hsa-3371568 attenuation phase
- R-hsa-9612973 autophagy
- R-hsa-9824439 bacterial infection pathways
- R-hsa-211859 biological oxidations
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-9613829 chaperone mediated autophagy
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Mediation Categories (4)
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence89
Enzyme-Mediated Modification (18)
18 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HSP90AB1 | CSNK2A1 | P68400 | S | 226 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:16964243KEA:2492519KEA:92065884phosphoELM:2492519SIGNOR:18591256KEA:18088087KEA:17081983ProtMapper:18591256KEA:1956339 |
| HSP90AB1 | CSNK2A1 | P68400 | S | 255 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935KEA:16964243KEA:2492519KEA:92065884phosphoELM:2492519ProtMapper:18591256SIGNOR:18591256KEA:16094384KEA:18088087KEA:16565220KEA:17081983KEA:1956339KEA:15822905 |
| HSP90AB1 | CSNK2A1 | P68400 | S | 718 | phosphorylation | PhosphoSitePhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | S | 48 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | T | 60 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | S | 261 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | T | 297 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | SRC | P12931 | Y | 301 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPNCI-PID_ProtMapperSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17855507ProtMapper:17855507 |
| HSP90AB1 | PRKACA | P17612 | T | 89 | phosphorylation | PhosphoSite | |
| HSP90AB1 | GSK3B | P49841 | S | 718 | phosphorylation | PhosphoSite |
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Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | ||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes |
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Regulatory Interaction Network (13)
13 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HS90B | P08238 | HAKAI | Q75N03 | Yes | Yes | SIGNOR | SIGNOR:31952268 | |
| FNIP2 | Q9P278 | HS90B | P08238 | Yes | Yes | SIGNOR | SIGNOR:27353360 | |
| KCC1B | Q6P2M8 | HS90B | P08238 | Yes | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:30992362 |
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Protein Complex Composition (37)
37 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HSP90AB1 | P08238 | 3 | PDB | PDB:6n8wPDB:5uciPDB:5ucjPDB:5uc4PDB:8eobPDB:7uljPDB:5uchPDB:3pry | ||
| AARS1EEF1A2EEF1B2EEF1DEEF1GHSP90AB1HSPA1BTSSK6UBCVARS1YWHAZ | P08238P0CG48P0DMV9P24534P26640P26641P29692P49588P63104Q05639Q9BXA6 | 1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7994 | ||
| GRB2HSP90AB1SPTAN1UBCYWHABYWHAZ | P08238P0CG48P31946P62993P63104Q13813 | 1:1:1:1:1:1 | CompleatCFinder | Compleat:HC6572 | ||
| CSNK2A1HSP90AB1HSPH1RELAUBC | P08238P0CG48P68400Q04206Q92598 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC5736 | ||
| CDC37CDK4HSP90AB1 | P08238P11802Q16543 | 2:1:1 | PDB | PDB:5fwkPDB:5fwpPDB:5fwlPDB:5fwm | ||
| HSP90AB1HSPA1LMAPK6MAPKAPK5MTG2TAB1 | P08238P34931Q15750Q16659Q8IW41Q9H4K7 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6356 | ||
| FKBP4HSP90AB1 | P08238Q02790 | 2:3 | PDB | PDB:1qz2 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
724
Mass
83,264
Sequence
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
3D Structural Models
Turn
34..37; 79..82; 341..344; 460..464; 505..507; 571..574
Helix
19..30; 38..60; 62..65; 95..99; 101..118; 123..129; 132..138; 187..193; 195..205; 288..290; 293..295; 298..309; 367..369; 372..374; 395..420; 423..443; 445..447; 448..453; 469..474; 491..495; 498..504; 518..525; 547..570; 600..607; 614..616; 617..619; 633..644; 649..665; 673..688; 716..720
Beta Strand
2..6; 13..16; 73..78; 83..88; 140..148; 150..152; 155..159; 161..163; 164..169; 176..185; 206..208; 213..215; 217..219; 277..282; 316..323; 325..327; 329..335; 346..348; 353..357; 360..364; 378..386; 456..459; 482..486; 510..512; 526..528; 531..535; 538..540; 576..580; 585..593; 595..598; 610..612; 624..628; 630..632
3D Structure
Electron microscopy (15); NMR spectroscopy (1); X-ray crystallography (15)
Domain & Motif Annotations
Compositional Bias
225..244; Acidic residues
Motif
720..724; TPR repeat-binding
Domain (CC)
The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Region
2..527; Interaction with TP53; 2..214; Interaction with BIRC2; 9..231; Interaction with NR3C1; 215..552; Interaction with AHSA1; 222..270; Disordered; 264..608; Interaction with NR3C1; 620..723; Interaction with NR1D1; 696..724; Disordered
Protein Families
Heat shock protein 90 family
Sequence Similarities
Belongs to the heat shock protein 90 family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs (45)
ZEARALENONERETASPIMYCIN HYDROCHLORIDECYCLOPROPARADICICOLCUCURBITACIN DTYRPHOSTIN AG 555ZEARALANONEHSP90 INHIBITOR LAM-003ASNX 5422RADANAMYCINTETRACYCLINEMONOCILLIN IHSP90 INHIBITOR XL888TANESPIMYCINSILIBININALVESPIMYCINPU-H71ZERANOLCOUMERMYCINRETASPIMYCINGAMBOGIC ACIDDAUNORUBICIN HYDROCHLORIDEBEVACIZUMAB-AWWBASPIRINTAS-116GANETESPIBCHEMBL:CHEMBL192264CHEMBL:CHEMBL578512RHEINDOXORUBICIN HYDROCHLORIDESNX-5422RADICICOLONALESPIBCD24FCLUMINESPIBNOVOBIOCINDIACETYLRHEINHSP90 INHIBITOR DEBIO 0932BIIB021CHEMBL:CHEMBL2022241CELASTROLGEDUNINGELDANAMYCINAUY922DERRUBONEMASOPROCOL
Interaction Protein (65)
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
Interaction Count
65
Interaction Dataset (6)
intact_biogridintact_biogrid_opencellbiogrid_opencellintact_biogrid_bioplexintact_biogrid_opencell_bioplexbiogrid_bioplex
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No related sentences available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No related sentences available |