Protein detail
HS90B
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Protein symbol HS90B | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Protein Class
Cancer-related genesPlasma proteinsPredicted intracellular proteinsTransporters
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym
HSPC2HSPCB
Gene Description
Heat shock protein 90 alpha family class B member 1
Chromosome
6
Position
44246166-44253888
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificOligodendrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0008180 COP9 signalosome
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0032991 protein-containing complex
- GO:0034751 aryl hydrocarbon receptor complex
- GO:0034774 secretory granule lumen
- GO:0042470 melanosome
- GO:0043025 neuronal cell body
- GO:0044294 dendritic growth cone
- GO:0044295 axonal growth cone
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0101031 protein folding chaperone complex
- GO:0120293 dynein axonemal particle
- GO:1904813 ficolin-1-rich granule lumen
- GO:1990565 HSP90-CDC37 chaperone complex
Molecular Function
- GO:0003723 RNA binding
- GO:0003725 double-stranded RNA binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016887 ATP hydrolysis activity
- GO:0019887 protein kinase regulator activity
- GO:0019900 kinase binding
- GO:0019901 protein kinase binding
- GO:0023026 MHC class II protein complex binding
- GO:0030235 nitric-oxide synthase regulator activity
- GO:0030911 TPR domain binding
- GO:0031072 heat shock protein binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0042277 peptide binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0042826 histone deacetylase binding
- GO:0043008 ATP-dependent protein binding
- GO:0044183 protein folding chaperone
- GO:0045296 cadherin binding
- GO:0046983 protein dimerization activity
- GO:0048156 tau protein binding
- GO:0051082 unfolded protein binding
- GO:0070182 DNA polymerase binding
- GO:0097718 disordered domain specific binding
- GO:0140662 ATP-dependent protein folding chaperone
- GO:0141069 receptor ligand inhibitor activity
- GO:1990226 histone methyltransferase binding
Biological Process
KEGG
- hsa04141 Protein processing in endoplasmic reticulum
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04612 Antigen processing and presentation
- KEGG:hsa04621 NOD-like receptor signaling pathway
- KEGG:hsa04657 IL-17 signaling pathway
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04914 Progesterone-mediated oocyte maturation
- KEGG:hsa04915 Estrogen signaling pathway
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05207 Chemical carcinogenesis - receptor activation
- KEGG:hsa05215 Prostate cancer
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-8937144 aryl hydrocarbon receptor signalling
- R-hsa-3371568 attenuation phase
- R-hsa-9612973 autophagy
- R-hsa-9824439 bacterial infection pathways
- R-hsa-211859 biological oxidations
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-9613829 chaperone mediated autophagy
- R-hsa-168928 ddx58 ifih1 mediated induction of interferon alpha beta
- R-hsa-9920588 dengue virus activates modulates innate and adaptive immune responses
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-8939211 esr mediated signaling
- R-hsa-9018519 estrogen dependent gene expression
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-3371511 hsf1 activation
- R-hsa-3371571 hsf1 dependent transactivation
- R-hsa-3371497 hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand
- R-hsa-5663205 infectious disease
- R-hsa-622312 inflammasomes
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-453274 mitotic g2 g2 m phases
- R-hsa-9675108 nervous system development
- R-hsa-6798695 neutrophil degranulation
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-211945 phase i functionalization of compounds
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9660826 purinergic signaling in leishmaniasis infection
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820965 respiratory syncytial virus rsv genome replication transcription and translation
- R-hsa-9013418 rhobtb2 gtpase cycle
- R-hsa-9706574 rhobtb gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9705671 sars cov 2 activates modulates innate and adaptive immune responses
- R-hsa-9705683 sars cov 2 host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-399954 sema3a pak dependent axon repulsion
- R-hsa-373755 semaphorin interactions
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-844456 the nlrp3 inflammasome
- R-hsa-8852276 the role of gtse1 in g2 m progression after g2 checkpoint
- R-hsa-5339562 uptake and actions of bacterial toxins
- R-hsa-5336415 uptake and function of diphtheria toxin
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
18 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HSP90AB1 | CSNK2A1 | P68400 | S | 226 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:16964243KEA:2492519KEA:92065884phosphoELM:2492519SIGNOR:18591256KEA:18088087KEA:17081983ProtMapper:18591256KEA:1956339 |
| HSP90AB1 | CSNK2A1 | P68400 | S | 255 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15302935KEA:16964243KEA:2492519KEA:92065884phosphoELM:2492519ProtMapper:18591256SIGNOR:18591256KEA:16094384KEA:18088087KEA:16565220KEA:17081983KEA:1956339KEA:15822905 |
| HSP90AB1 | CSNK2A1 | P68400 | S | 718 | phosphorylation | PhosphoSitePhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | S | 48 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | T | 60 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | S | 261 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | CSNK2A1 | P68400 | T | 297 | phosphorylation | PhosphoNetworks | |
| HSP90AB1 | SRC | P12931 | Y | 301 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPNCI-PID_ProtMapperSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17855507ProtMapper:17855507 |
| HSP90AB1 | PRKACA | P17612 | T | 89 | phosphorylation | PhosphoSite | |
| HSP90AB1 | GSK3B | P49841 | S | 718 | phosphorylation | PhosphoSite |
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Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | No | No |
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | No | No |
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Regulatory Interaction Network
13 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HS90B | P08238 | HAKAI | Q75N03 | Yes | Yes | No | SIGNOR | SIGNOR:31952268 |
| FNIP2 | Q9P278 | HS90B | P08238 | Yes | No | Yes | SIGNOR | SIGNOR:27353360 |
| KCC1B | Q6P2M8 | HS90B | P08238 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:30992362 |
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Protein Complex Composition
37 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| 9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex | AHRAIPHSP90AA1HSP90AB1 | O00170P07900P08238P35869 | 1:1:1:1 | Compleat | Compleat:HC763 | 1310021 |
| CAPN1-HSP90AB1 complex | CAPN1HSP90AB1 | P07384P08238 | 0:0 | CORUM | CORUM:6706 | 25575026 |
| CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex | CDC37HSP90AA1HSP90AB1MAP3K11 | P07900P08238Q16543Q16584 | 1:1:1:1 | CompleatCORUM | Compleat:HC2090CORUM:2112 | 15001580 |
| HSP90-CDC37-LRRK2 complex | CDC37HSP90AB1LRRK2 | P08238Q16543Q5S007 | 1:1:1 | CompleatCORUM | CORUM:5849Compleat:HC2611 | 16321986 |
| HSP90-FKBP38-CAM-Ca(2+) complex | CALM3FKBP8HSP90AA1HSP90AB1 | P07900P08238P0DP25Q14318 | 1:1:1:1 | Compleat | Compleat:HC783 | 17379601 |
| HSP90B-CDC37 chaperone complex | CDC37HSP90AB1 | P08238Q16543 | 2:2 | ComplexPortal | 183591161938755014755292 | |
| IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex | CCAR2CDC37HSP90AA1HSP90AB1IKBKB | O14920P07900P08238Q16543Q8N163 | 1:1:1:1:1 | CompleatCORUM | CORUM:5234Compleat:HC3178 | 14743216 |
| Kinase maturation complex 2 | AZI2CDC37HSP90AA1HSP90AB1TANKTBK1TBKBP1TRAF2 | A7MCY6P07900P08238Q12933Q16543Q92844Q9H6S1Q9UHD2 | 1:1:1:1:1:1:1:1 | CompleatCORUM | CORUM:5212Compleat:HC227 | 14743216 |
| Metallothionein-3 complex | ACTBACTG1CKBCKMDPYSL2HSP90AA1HSP90AB1HSPA1BMT3POTEI | P06732P07900P08238P0CG38P0DMV9P12277P25713P60709P63261Q16555 | 1:1:1:1:2:1:1:1:1:1 | Compleat | Compleat:HC2415 | 17018872 |
| Mt3-Hsp84-Ck complex | CKBCKMHSP90AA1HSP90AB1MT3 | P06732P07900P08238P12277P25713 | 1:1:1:1:1 | Compleat | Compleat:HC1412 | 17018872 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
724
Mass
83,264
Sequence
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
3D Structural Models
Turn
34..37; 79..82; 341..344; 460..464; 505..507; 571..574
Helix
19..30; 38..60; 62..65; 95..99; 101..118; 123..129; 132..138; 187..193; 195..205; 288..290; 293..295; 298..309; 367..369; 372..374; 395..420; 423..443; 445..447; 448..453; 469..474; 491..495; 498..504; 518..525; 547..570; 600..607; 614..616; 617..619; 633..644; 649..665; 673..688; 716..720
Beta Strand
2..6; 13..16; 73..78; 83..88; 140..148; 150..152; 155..159; 161..163; 164..169; 176..185; 206..208; 213..215; 217..219; 277..282; 316..323; 325..327; 329..335; 346..348; 353..357; 360..364; 378..386; 456..459; 482..486; 510..512; 526..528; 531..535; 538..540; 576..580; 585..593; 595..598; 610..612; 624..628; 630..632
3D Structure
Electron microscopy (15); NMR spectroscopy (1); X-ray crystallography (15)
Domain & Motif Annotations
Compositional Bias
225..244; Acidic residues
Motif
720..724; TPR repeat-binding
Domain (CC)
The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Region
2..527; Interaction with TP53; 2..214; Interaction with BIRC2; 9..231; Interaction with NR3C1; 215..552; Interaction with AHSA1; 222..270; Disordered; 264..608; Interaction with NR3C1; 620..723; Interaction with NR1D1; 696..724; Disordered
Protein Families
Heat shock protein 90 family
Sequence Similarities
Belongs to the heat shock protein 90 family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
ZEARALENONERETASPIMYCIN HYDROCHLORIDECYCLOPROPARADICICOLCUCURBITACIN DTYRPHOSTIN AG 555ZEARALANONEHSP90 INHIBITOR LAM-003ASNX 5422RADANAMYCINTETRACYCLINEMONOCILLIN IHSP90 INHIBITOR XL888TANESPIMYCINSILIBININALVESPIMYCINPU-H71ZERANOLCOUMERMYCINRETASPIMYCINGAMBOGIC ACIDDAUNORUBICIN HYDROCHLORIDEBEVACIZUMAB-AWWBASPIRINTAS-116GANETESPIBCHEMBL:CHEMBL192264CHEMBL:CHEMBL578512RHEINDOXORUBICIN HYDROCHLORIDESNX-5422RADICICOLONALESPIBCD24FCLUMINESPIBNOVOBIOCINDIACETYLRHEINHSP90 INHIBITOR DEBIO 0932BIIB021CHEMBL:CHEMBL2022241CELASTROLGEDUNINGELDANAMYCINAUY922DERRUBONEMASOPROCOL
Interaction Protein
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
Interaction Count
65
Interaction Dataset
intact_biogridintact_biogrid_opencellbiogrid_opencellintact_biogrid_bioplexintact_biogrid_opencell_bioplexbiogrid_bioplex