Protein detail

PTPRC

Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)

Protein symbol PTPRC	UniProt ID P08575	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)

Protein Class

Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
CD markers
Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Cancer-related genes
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

578..598; Helical

Transmembrane Count

Ensembl

ENSG00000081237

Entrez Gene Symbol

PTPRC

Gene Synonym

CD45GP180LCAT200

Gene Description

Protein tyrosine phosphatase receptor type C

Chromosome

Position

198638457-198757476

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Predicted intracellular proteins
CD markers
Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Enzymes
ENZYME proteins:Hydrolases
Cancer-related genes
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

28 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTPRC	CSNK2A1	P68400	S	1,002	phosphorylation	phosphoELMHPRDKEA	phosphoELM:10066810 HPRD:10066810 KEA:10066810
PTPRC	CSNK2A1	P68400	S	1,009	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper	ProtMapper:10066810 SIGNOR:10066810
PTPRC	CSNK2A1	P68400	S	1,005	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper	ProtMapper:10066810 SIGNOR:10066810
PTPRC	CSNK2A1	P68400	S	1,004	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper	ProtMapper:10066810 SIGNOR:10066810
PTPRC	CSNK2A1	P68400	S	1,001	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper	ProtMapper:10066810 SIGNOR:10066810
PTPRC	CSNK2A1	P68400	S	842	phosphorylation	KEA	KEA:15302935 KEA:10066810
PTPRC	CSNK2A1	P68400	S	846	phosphorylation	KEA	KEA:15302935 KEA:9111075 KEA:10066810
PTPRC	CSNK2A1	P68400	S	954	phosphorylation	KEA	KEA:10066810
PTPRC	CSNK2A1	P68400	S	955	phosphorylation	KEA	KEA:15302935 KEA:10066810
PTPRC	CSNK2A1	P68400	S	959	phosphorylation	KEA	KEA:15302935 KEA:9111075 KEA:10066810

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Ligand-Receptor Signaling

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No

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Regulatory Interaction Network

12 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRC	P08575	LYN	P07948	Yes	Yes	Yes	SPIKEWangNCI-PID_ProtMapperNetPathSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapperHPRD-phosSPIKE_LC	DEPOD:10415030 HPRD:10415030 NetPath:7525568 ProtMapper:10415030 HPRD:12393728 SIGNOR:10415030 SPIKE:7525568 HPRD-phos:10415030 SPIKE_LC:7525568 DEPOD:7499277 ProtMapper:7499277
PTPRC	P08575	SKAP1	Q86WV1	Yes	Yes	No	SPIKEWangNetPathSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapperLit-BM-17HPRD-phosSPIKE_LC	SPIKE:11909961 HPRD-phos:11909961 NetPath:11909961 DEPOD:11909961 HPRD:11909961 Lit-BM-17:11909961 ProtMapper:11909961 SIGNOR:11909961 SPIKE_LC:11909961
PTPRC	P08575	JAK3	P52333	Yes	Yes	Yes	HPRDSIGNORSignaLink3DEPOD	SignaLink3:11994288 HPRD:11994288 DEPOD:11994288 SIGNOR:11201744 SignaLink3:23331499 SIGNOR:11994288
PTPRC	P08575	JAK1	P23458	Yes	Yes	Yes	WangSIGNORProtMapperDEPODHPRDSignaLink3SIGNOR_ProtMapper	ProtMapper:11201744 SignaLink3:11994288 DEPOD:11994288 DEPOD:11201744 SignaLink3:11201744 SIGNOR:11201744 SignaLink3:23331499 SIGNOR:11994288 HPRD:11201744
PTPRC	P08575	JAK2	O60674	Yes	No	Yes	SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper	ProtMapper:11201744 DEPOD:11201744 SIGNOR:11201744 HPRD:11201744 SIGNOR:24252238
PTPRC	P08575	TYK2	P29597	Yes	No	Yes	SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper	HPRD:11201744 SIGNOR:11201744 ProtMapper:11201744 DEPOD:11201744
PTPRC	P08575	FYN	P06241	Yes	Yes	No	WangNCI-PID_ProtMapperSIGNORProtMapperDEPODHPRDKinexus_KEAKEASIGNOR_ProtMapperHPRD-phosSPIKE_LC	HPRD:8980254 DEPOD:1533589 ProtMapper:1464315 HPRD:12589038 HPRD-phos:9535845 HPRD:9368621 KEA:1985196 ProtMapper:11909961 SPIKE_LC:16713569 HPRD-phos:8980254 SIGNOR:11909961 HPRD:9535845
CSK22	P19784	PTPRC	P08575	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	KEA:15302935 KEA:10066810 HPRD-phos:10066810 SIGNOR:10066810 ProtMapper:10066810 HPRD:10066810
PTPRC	P08575	LCK	P06239	Yes	Yes	Yes	WangNCI-PID_ProtMapperSIGNORProtMapperDEPODHPRDCui2007HINTKEABioGRIDKinexus_KEAIntActReactome_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperHPRD-phosSPIKE_LC	DEPOD:2141630 HINT:8576115 IntAct:8576115 DEPOD:8576115 HINT:7507203 HPRD:12589038 SPIKE_LC:17145710 ProtMapper:2548204 HPRD-phos:12589038 ProtMapper:21543337 BioGRID:15085197 HINT:10369126 ProtMapper:20346773 HPRD:9973453 BioGRID:8473339 ProtMapper:10360179 IntAct:19167335 HPRD:10330160 SIGNOR:11259588 DEPOD:8441403 ProtMapper:11827988 ProtMapper:19290918 HINT:14625311 HPRD:8473339 IntAct:7507203 HPRD:8663450 HPRD-phos:9973453 BioGRID:8576115 ProtMapper:11259588 KEA:15743820 SIGNOR:17719247 HPRD-phos:11369760 DEPOD:8433999 HPRD:11369760 ProtMapper:17719247 DEPOD:2530588 HPRD:8576115 IntAct:10369126 HPRD-phos:10330160 ProtMapper:2141684 HINT:24463463 HPRD-phos:8663450
PTPRC	P08575	KPCD	Q05655	Yes	No	Yes	SIGNOR	SIGNOR:11124968

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Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
JAK-STAT-Ncore	CISH IL22RA2 IRAK1 IRAK2 PIAS1 PIAS2 PIAS3 PIAS4 PTPN1 PTPN11 PTPN2 PTPN6 PTPRC RACK1 SH2B1 SOCS1 SOCS3 STAM	O14543 O15524 O43187 O75925 O75928 P08575 P17706 P18031 P29350 P51617 P63244 Q06124 Q8N2W9 Q92783 Q969J5 Q9NRF2 Q9NSE2 Q9Y6X2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2351
	PTPRC	P08575	2	PDB	PDB:5fn7PDB:5fmv

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37466513

Sequence, Structure & Domains

Sequences

Length

1,306

Mass

147,486

Sequence

MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

Alternative Products

Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=CD45RABC; IsoId=P08575-3; Sequence=Displayed; Name=2; Synonyms=CD45R0, CD45RO; IsoId=P08575-4; Sequence=VSP_059409; Name=3; Synonyms=CD45RAB; IsoId=P08575-5; Sequence=VSP_059837; Name=4; Synonyms=CD45RAC; IsoId=P08575-6; Sequence=VSP_059836; Name=5; Synonyms=CD45RBC; IsoId=P08575-7; Sequence=VSP_059834; Name=6; Synonyms=CD45RA; IsoId=P08575-8; Sequence=VSP_059835; Name=7; Synonyms=CD45RB; IsoId=P08575-9; Sequence=VSP_059834, VSP_059837; Name=8; Synonyms=CD45RC; IsoId=P08575-10; Sequence=VSP_059833

Alternative Sequence

34..194; Missing (in isoform 2); 34..146; Missing (in isoform 8); 34..99; Missing (in isoform 5 and isoform 7); 100..194; Missing (in isoform 6); 100..146; Missing (in isoform 4); 147..194; Missing (in isoform 3 and isoform 7)

3D Structural Models

Turn

232..234; 243..246; 317..319; 635..637; 670..672; 690..692; 703..706; 730..732; 769..771; 981..983; 1040..1042; 1209..1212

Helix

228..231; 266..268; 303..305; 314..316; 335..337; 638..658; 675..680; 733..742; 828..838; 858..871; 873..876; 881..889; 899..915; 922..924; 925..932; 943..950; 962..964; 968..970; 1043..1052; 1134..1145; 1176..1191; 1197..1207; 1215..1227

Beta Strand

237..242; 247..252; 259..263; 269..273; 278..284; 288..291; 293..298; 306..310; 321..327; 338..344; 347..356; 364..373; 376..388; 396..401; 403..406; 408..413; 420..427; 429..438; 443..446; 454..470; 474..479; 489..499; 501..506; 518..541; 549..557; 566..571; 665..667; 693..695; 700..702; 707..713; 716..718; 722..725; 747..750; 754..756; 759..761; 773..776; 779..788; 790..804; 809..816; 849..852; 854..857; 877..879; 1020..1024; 1031..1036; 1057..1060; 1064..1066; 1069..1072; 1090..1095; 1097..1107; 1115..1122; 1127..1129; 1165..1173; 1192..1194

3D Structure

Electron microscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

52..61; Polar residues; 70..131; Polar residues; 999..1012; Acidic residues

Domain (CC)

The first PTPase domain interacts with SKAP1.

Domain (FT)

391..483; Fibronectin type-III 1; 484..576; Fibronectin type-III 2; 653..912; Tyrosine-protein phosphatase 1; 944..1228; Tyrosine-protein phosphatase 2

Region

28..163; Disordered; 993..1014; Disordered; 1261..1306; Disordered

Protein Families

Protein-tyrosine phosphatase family
Receptor class 1/6 subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantSCID

Related Diseases

Acute myeloid leukaemia Diffuse large B-cell lymphoma Leukaemia Lymphoma Malignant haematopoietic neoplasm Pain Transplant rejection Transplanted organ/tissue

Biomarker

Phase 3; Phase 1; Phase 2; Terminated

Drugs

VACCINE ALENDRONATE SODIUM FLUOROURACIL NULL 1,2-DIHYDROXYNAPHTHALENE MILODISTIM IODINE I 131 APAMISTAMAB HYDROGEN PEROXIDE EPOETIN ALFA RECOMBINANT HUMAN THROMBOPOIETIN ESTRADIOL VALERATE HYDROCORTISONE BUTYRATE BC8 131I PREDNISONE AHN-12 PROTEIN KINASE INHIBITOR ANTIOXIDANT IMMUNOSUPPRESSANT HEPARAN SULFATE

Antibody

CAB000052 HPA000440 CAB002800 CAB056154 CAB068221 CAB080251

Interaction Protein

ENSG00000005844ENSG00000182866

Interaction Count

Interaction Dataset

intact_biogrid