Protein detail
PTPRC
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
Protein symbol PTPRC | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Cancer-related genes
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
578..598; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD45GP180LCAT200
Gene Description
Protein tyrosine phosphatase receptor type C
Chromosome
1
Position
198638457-198757476
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- ENZYME proteins:Hydrolases
- Cancer-related genes
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0009897 external side of plasma membrane
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030667 secretory granule membrane
- GO:0032059 bleb
- GO:0045121 membrane raft
- GO:0045202 synapse
- GO:0070062 extracellular exosome
- GO:0098857 membrane microdomain
Molecular Function
- GO:0004725 protein tyrosine phosphatase activity
- GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0008201 heparin binding
- GO:0019901 protein kinase binding
- GO:0030506 ankyrin binding
- GO:0030507 spectrin binding
- GO:0043395 heparan sulfate proteoglycan binding
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-168249 innate immune system
- R-hsa-9675108 nervous system development
- R-hsa-6798695 neutrophil degranulation
- R-hsa-416700 other semaphorin interactions
- R-hsa-202427 phosphorylation of cd3 and tcr zeta chains
- R-hsa-373755 semaphorin interactions
- R-hsa-202403 tcr signaling
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
28 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PTPRC | CSNK2A1 | P68400 | S | 992 | phosphorylation | KEA | KEA:10066810 |
| PTPRC | CSNK2A1 | P68400 | S | 996 | phosphorylation | KEA | KEA:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 1,001 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper | ProtMapper:10066810SIGNOR:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 1,004 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper | ProtMapper:10066810SIGNOR:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 1,009 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper | ProtMapper:10066810SIGNOR:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 1,005 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapper | ProtMapper:10066810SIGNOR:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 1,002 | phosphorylation | HPRDKEA | HPRD:10066810KEA:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 842 | phosphorylation | KEA | KEA:15302935KEA:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 954 | phosphorylation | KEA | KEA:10066810 |
| PTPRC | CSNK2A2 | P19784 | S | 955 | phosphorylation | KEA | KEA:15302935KEA:10066810 |
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | PTPRC | P08575 | Yes | Yes | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos | KEA:15302935KEA:10066810HPRD-phos:10066810SIGNOR:10066810KEA:9111075ProtMapper:10066810HPRD:10066810phosphoELM:10066810 |
| CSK | P41240 | PTPRC | P08575 | Yes | Yes | No | SIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksKinexus_KEAIntActWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAphosphoELMSIGNOR_ProtMapperPhosphoSite | SIGNOR:7507203KEA:7507203PhosphoSite:7507203phosphoELM:7507203HINT:7507203IntAct:19167335IntAct:7507203ProtMapper:7507203iPTMnet:7507203 |
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Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| JAK-STAT-Ncore | CISHIL22RA2IRAK1IRAK2PIAS1PIAS2PIAS3PIAS4PTPN1PTPN11PTPN2PTPN6PTPRCRACK1SH2B1SOCS1SOCS3STAM | O14543O15524O43187O75925O75928P08575P17706P18031P29350P51617P63244Q06124Q8N2W9Q92783Q969J5Q9NRF2Q9NSE2Q9Y6X2 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2351 | |
| PTPRC | P08575 | 2 | PDB | PDB:5fn7PDB:5fmv |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37466513 |
Sequence, Structure & Domains
Sequences
Length
1,306
Mass
147,486
Sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=CD45RABC; IsoId=P08575-3; Sequence=Displayed; Name=2; Synonyms=CD45R0, CD45RO; IsoId=P08575-4; Sequence=VSP_059409; Name=3; Synonyms=CD45RAB; IsoId=P08575-5; Sequence=VSP_059837; Name=4; Synonyms=CD45RAC; IsoId=P08575-6; Sequence=VSP_059836; Name=5; Synonyms=CD45RBC; IsoId=P08575-7; Sequence=VSP_059834; Name=6; Synonyms=CD45RA; IsoId=P08575-8; Sequence=VSP_059835; Name=7; Synonyms=CD45RB; IsoId=P08575-9; Sequence=VSP_059834, VSP_059837; Name=8; Synonyms=CD45RC; IsoId=P08575-10; Sequence=VSP_059833
Alternative Sequence
34..194; Missing (in isoform 2); 34..146; Missing (in isoform 8); 34..99; Missing (in isoform 5 and isoform 7); 100..194; Missing (in isoform 6); 100..146; Missing (in isoform 4); 147..194; Missing (in isoform 3 and isoform 7)
3D Structural Models
Turn
232..234; 243..246; 317..319; 635..637; 670..672; 690..692; 703..706; 730..732; 769..771; 981..983; 1040..1042; 1209..1212
Helix
228..231; 266..268; 303..305; 314..316; 335..337; 638..658; 675..680; 733..742; 828..838; 858..871; 873..876; 881..889; 899..915; 922..924; 925..932; 943..950; 962..964; 968..970; 1043..1052; 1134..1145; 1176..1191; 1197..1207; 1215..1227
Beta Strand
237..242; 247..252; 259..263; 269..273; 278..284; 288..291; 293..298; 306..310; 321..327; 338..344; 347..356; 364..373; 376..388; 396..401; 403..406; 408..413; 420..427; 429..438; 443..446; 454..470; 474..479; 489..499; 501..506; 518..541; 549..557; 566..571; 665..667; 693..695; 700..702; 707..713; 716..718; 722..725; 747..750; 754..756; 759..761; 773..776; 779..788; 790..804; 809..816; 849..852; 854..857; 877..879; 1020..1024; 1031..1036; 1057..1060; 1064..1066; 1069..1072; 1090..1095; 1097..1107; 1115..1122; 1127..1129; 1165..1173; 1192..1194
3D Structure
Electron microscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
52..61; Polar residues; 70..131; Polar residues; 999..1012; Acidic residues
Domain (CC)
The first PTPase domain interacts with SKAP1.
Domain (FT)
391..483; Fibronectin type-III 1; 484..576; Fibronectin type-III 2; 653..912; Tyrosine-protein phosphatase 1; 944..1228; Tyrosine-protein phosphatase 2
Region
28..163; Disordered; 993..1014; Disordered; 1261..1306; Disordered
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 1/6 subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantSCID
Related Diseases
Biomarker
Phase 3; Phase 1; Phase 2; Terminated
Drugs
Interaction Protein
ENSG00000005844ENSG00000182866
Interaction Count
2
Interaction Dataset
intact_biogrid