EV MemProt Atlas

Basic Information13

Protein Names

Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

Protein Class (11)

Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteinsTransporters

Protein Function (17)

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Nervous system diseases:Ear disease
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Human disease related genes:Cancers:Cancers of soft tissues and bone
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers

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Transmembrane

933..955; Helical

Transmembrane Count

1

Ensembl

ENSG00000105976

Entrez Gene Symbol

MET

Gene Synonym (3)

DFNB97HGFRRCCP2

Gene Description

MET proto-oncogene, receptor tyrosine kinase

Chromosome

7

Position

116672196-116798377

Supporting publications (n)

3

EVMP confidence score

0.38

Fluorescence & Localization7

Tissue SpecificintestineBrain Regional Specificbasal gangliaCell SpecificAdipocytesSingle-Nuclei Brain Specificlower rhombic lipBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (17)

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Nervous system diseases:Ear disease
Predicted intracellular proteins
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Human disease related genes:Cancers:Cancers of soft tissues and bone
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers

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Cellular Component (7)

Molecular Function (8)

Biological Process (3)

KEGG (25)

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Reactome (33)

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Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence242

Enzyme-Mediated Modification (71)

71 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MET	PTPRG	P23470	Y	1,003	dephosphorylation	SIGNOR	SIGNOR:25624455
MET	PTPRG	P23470	Y	1,003	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:25624455
MET	PTPRJ	Q12913	Y	1,365	dephosphorylation	SIGNORDEPOD	SIGNOR:12475979 DEPOD:12475979
MET	PTPRJ	Q12913	Y	1,349	dephosphorylation	HPRDSIGNORDEPOD	HPRD:12370829 SIGNOR:12475979 DEPOD:12475979
MET	PTPRJ	Q12913	Y	1,356	dephosphorylation	HPRD	HPRD:12370829
MET	PTPRJ	Q12913	Y	1,356	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:12475979
MET	PTPRJ	Q12913	Y	1,349	phosphorylation	NCI-PID_ProtMapperProtMapperReactome_ProtMapperKEASIGNOR_ProtMapper	ProtMapper:12475979 KEA:15475459
MET	PTPRJ	Q12913	Y	1,003	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:12475979
MET	PTPRJ	Q12913	Y	1,365	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:12475979
MET	PRKCA	P17252	S	985	phosphorylation	SIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:8294430 KEA:8294430 KEA:15075332 ProtMapper:8294430 KEA:17570479 KEA:94124523

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Ligand-Receptor Signaling (61)

61 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	GO_Intercell	No	Yes	Yes	Yes	No
receptor	receptor	HPMR	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No

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Regulatory Interaction Network (28)

28 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
HGF	P14210	MET	P08581	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTSignaLink3UniProt_LRdbDIPLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015BEL-Large-Corpus_ProtMapperHPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	Cellinker:15167892 LRdb:1846706 ProtMapper:24362531 Lit-BM-17:17804794 ProtMapper:27147579 HINT:15167892 DIP:16537482 SPIKE_LC:17145710 DIP:20624990 HPRD:1655405 HINT:17804794 SIGNOR:8380735 HINT:15161915 SPIKE:17145710 HINT:8380735 Lit-BM-17:17981115 ProtMapper:22001117 IntAct:17804794 SPIKE_LC:14685170 Cellinker:28475121 Cellinker:18495663 HPRD:15167892 ProtMapper:16397249 IntAct:20624990 SignaLink3:8380735 LRdb:1655405 Cellinker:1655405 HINT:23882082 IntAct:1846706 connectomeDB2020:1655405 HPRD:18495663 IntAct:22897854 LRdb:18495663 Lit-BM-17:22897854 HINT:24859116 Lit-BM-17:15167892 HINT:17981115 ProtMapper:28534512 connectomeDB2020:1846706 CellTalkDB:1846706 Lit-BM-17:1846706 connectomeDB2020:18495663 connectomeDB2020:15167892 SignaLink3:23331499 IntAct:15167892 SPIKE_LC:1846706 CellChatDB:28475121 Cellinker:1846706 ProtMapper:34064863 ProtMapper:17667909 ICELLNET:15218027 HINT:34210960 BioGRID:1655405 Lit-BM-17:19433454 IntAct:17981115 ProtMapper:20178463 SIGNOR:37450419 Lit-BM-17:8380735 SPIKE:14685170 SPIKE:1846706 LRdb:15167892 IntAct:16537482 DIP:17804794
MET	P08581	SHC1	P29353	Yes	Yes	No	SPIKEWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointProtMapperHPRDLi2012SPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapper	PhosphoSite:11687594 SPIKE_LC:14685170 Lit-BM-17:24728074 PhosphoSite:14990987 PhosphoSite:15688026 PhosphoSite:9083103 Lit-BM-17:9660480 PhosphoSite:8084588 PhosphoSite:8939605 SPIKE:14685170 PhosphoSite:8947042 PhosphoSite:11884620 HPRD:7731718
MET	P08581	GAB1	Q13480	Yes	Yes	No	SPIKEKEGG-MEDICUSHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksHPRDCui2007Kinexus_KEAWangBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LCHPRD-phos	HPRD-phos:18669648 KEA:11779868 KEA:15574420 HPRD-phos:10978177 KEA:10978177 SPIKE_LC:14685170 ProtMapper:15212693 SIGNOR:10734310 HINT:10913131 ProtMapper:17016520 HPRD-phos:20068231 HPRD-phos:10734310 SPIKE:10913131 KEA:10734310 ProtMapper:17389395 KEA:9890893 ProtMapper:10734310 HINT:11894096 ProtMapper:10978177 HPRD:10995442 KEA:10753869 HPRD-phos:19901323 HPRD-phos:17389395 HPRD:10734310 ProtMapper:16497976 ProtMapper:19901323 KEA:11896055 phosphoELM:10734310 SPIKE_LC:10913131 ProtMapper:20068231 HPRD-phos:16497976 ProtMapper:18669648 SPIKE:14685170 HPRD-phos:17016520
CBL	P22681	MET	P08581	Yes	Yes	Yes	DOMINOWangSparser_ProtMapperNCI-PID_ProtMapperSIGNORProtMapperREACH_ProtMapperHPRDHINTSignaLink3BioGRIDACSNIntActLMPIDSPIKE_LCLit-BM-17	HINT:15123609 HINT:21163258 Lit-BM-17:21163258 ACSN:17635922 IntAct:18273061 SignaLink3:16397241 IntAct:21163258 SignaLink3:19450681 BioGRID:17533376 IntAct:25241761 HPRD:11894096 LMPID:15123609 Lit-BM-17:18273061 BioGRID:19450681 Lit-BM-17:21222362 SIGNOR:19450681 HINT:18273061 SPIKE_LC:11894096 ProtMapper:18672314 ProtMapper:11741535 SignaLink3:18273061 ACSN:10514377 BioGRID:35309168 Lit-BM-17:11894096 Lit-BM-17:19450681 Lit-BM-17:16397241 HINT:11894096 ProtMapper:20331976 SignaLink3:15123609 HINT:21222362 SignaLink3:23331499 DOMINO:11894096 Lit-BM-17:25241761 SignaLink3:11894096 Lit-BM-17:15123609 Lit-BM-17:19433454 IntAct:11894096 ProtMapper:17635922 HPRD:18273061
MET	P08581	GLMN	Q92990	Yes	Yes	Yes	PhosphoPointSIGNORHPRDSignaLink3Lit-BM-17	Lit-BM-17:11571281 SIGNOR:11571281 SignaLink3:23331499 HPRD:11571281 SignaLink3:11571281
MET	P08581	GRAP	Q13588	Yes	Yes	No	SIGNORSignaLink3	SIGNOR:8662889 SignaLink3:8662889 SignaLink3:23331499
MET	P08581	RANB9	Q96S59	Yes	Yes	No	WangPhosphoPointSIGNORHPRDSignaLink3SPIKE_LCLit-BM-17	SIGNOR:12147692 HPRD:12147692 Lit-BM-17:12147692 SPIKE_LC:12147692 SignaLink3:12147692 SignaLink3:23331499
PTPRJ	Q12913	MET	P08581	Yes	No	Yes	WangNCI-PID_ProtMapperSIGNORProtMapperDEPODHPRDHINTReactome_ProtMapperKEAKinexus_KEAIntActSIGNOR_ProtMapperHPRD-phos	HINT:12475979 IntAct:12475979 SIGNOR:12475979 IntAct:19167335 KEA:15475459 HPRD:12370829 ProtMapper:12475979 HPRD-phos:12370829 DEPOD:12475979
PTN1	P18031	MET	P08581	Yes	No	Yes	WangNCI-PID_ProtMapperSIGNORProtMapperDEPODHINTReactome_ProtMapperIntActSIGNOR_ProtMapperLit-BM-17SPIKE_LC	SIGNOR:29920310 HINT:18579758 DEPOD:18819921 HINT:16537444 Lit-BM-17:22789536 SIGNOR:18819921 IntAct:22789536 SIGNOR:16537444 IntAct:16537444 IntAct:18579758 Lit-BM-17:16537444 ProtMapper:16537444 ProtMapper:18819921 SPIKE_LC:16537444 Lit-BM-17:18579758
MET	P08581	CAV1	Q03135	Yes	Yes	No	SIGNOR	SIGNOR:25148256

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Protein Complex Composition (81)

81 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GTPBP1 METTL16 NFYA	O00178 P23511 Q86W50	0:0:0	hu.MAP
GTPBP1 METTL16 PLCB3	O00178 Q01970 Q86W50	0:0:0	hu.MAP
GTPBP1 METTL16	O00178 Q86W50	0:0	hu.MAP
AFG2A HIBCH METTL17 MRPS10 MRPS11 MRPS12 MRPS15 MRPS16 MRPS17 MRPS21 MRPS23 MRPS35 MRPS7 MRPS9 ZNF593	O00488 O15235 P82664 P82673 P82912 P82914 P82921 P82933 Q6NVY1 Q8NB90 Q9H7H0 Q9Y2R5 Q9Y2R9 Q9Y3D3 Q9Y3D9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6078
BCKDK METTL21C	O14874 Q5VZV1	0:0	hu.MAPhu.MAP2
METTL25 MITF TFE3 TFEB TFEC	O14948 O75030 P19484 P19532 Q8N6Q8	0:0:0:0:0	hu.MAP2
DAP3 ERAL1 MCAT METTL17 MRPS10 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18B MRPS18C MRPS2 MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS31 MRPS33 MRPS34 MRPS35 MRPS5 MRPS6 MRPS7 MRPS9 NOA1 PTCD3 TFB1M	O15235 O60783 O75616 P51398 P82650 P82663 P82664 P82673 P82675 P82914 P82921 P82930 P82932 P82933 Q8IVS2 Q8NC60 Q8WVM0 Q92552 Q92665 Q96EL2 Q96EY7 Q9BYN8 Q9H7H0 Q9Y291 Q9Y2Q9 Q9Y2R5 Q9Y2R9 Q9Y399 Q9Y3D3 Q9Y3D5 Q9Y3D9 Q9Y676	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8csp
AURKAIP1 DAP3 ERAL1 MCAT METTL17 MRPS10 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18B MRPS18C MRPS2 MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS31 MRPS33 MRPS34 MRPS35 MRPS5 MRPS6 MRPS7 MRPS9 PTCD3 TFB1M	O15235 O60783 O75616 P51398 P82650 P82663 P82664 P82673 P82675 P82914 P82921 P82930 P82932 P82933 Q8IVS2 Q8WVM0 Q92552 Q92665 Q96EL2 Q96EY7 Q9BYN8 Q9H7H0 Q9NWT8 Q9Y291 Q9Y2Q9 Q9Y2R5 Q9Y2R9 Q9Y399 Q9Y3D3 Q9Y3D5 Q9Y3D9 Q9Y676	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8csq
AURKAIP1 DAP3 MCAT METTL17 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18B MRPS18C MRPS2 MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS31 MRPS33 MRPS34 MRPS35 MRPS5 MRPS6 MRPS7 MRPS9 PTCD3 RBFA TFB1M	O15235 O60783 P51398 P82650 P82663 P82664 P82673 P82675 P82912 P82914 P82921 P82930 P82932 P82933 Q8IVS2 Q8N0V3 Q8WVM0 Q92552 Q92665 Q96EL2 Q96EY7 Q9BYN8 Q9H7H0 Q9NWT8 Q9Y291 Q9Y2Q9 Q9Y2R5 Q9Y2R9 Q9Y399 Q9Y3D3 Q9Y3D5 Q9Y3D9 Q9Y676	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8csr
AURKAIP1 DAP3 MCAT METTL17 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18B MRPS18C MRPS2 MRPS21 MRPS22 MRPS23 MRPS24 MRPS25 MRPS26 MRPS27 MRPS28 MRPS31 MRPS33 MRPS34 MRPS35 MRPS5 MRPS6 MRPS7 MRPS9 PTCD3 RBFA	O15235 O60783 P51398 P82650 P82663 P82664 P82673 P82675 P82912 P82914 P82921 P82930 P82932 P82933 Q8IVS2 Q8N0V3 Q92552 Q92665 Q96EL2 Q96EY7 Q9BYN8 Q9H7H0 Q9NWT8 Q9Y291 Q9Y2Q9 Q9Y2R5 Q9Y2R9 Q9Y399 Q9Y3D3 Q9Y3D5 Q9Y3D9 Q9Y676	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:8css

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	6	38113368 37322475 40189497 36146834 31805958 38207106

Sequence, Structure & Domains14

Sequences

Length

1,390

Mass

155,541

Sequence

MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS

Alternative Products

Event=Alternative splicing; Named isoforms=3; Comment=Additional soluble isoforms seem to exist.; Name=1; IsoId=P08581-1; Sequence=Displayed; Name=2; IsoId=P08581-2; Sequence=VSP_005005; Name=3; Synonyms=Soluble MET variant 4; IsoId=P08581-3; Sequence=VSP_042447, VSP_042448

Alternative Sequence

755..764; SGGSTITGVG -> RHVNIALIQR (in isoform 3); 755; S -> STWWKEPLNIVSFLFCFAS (in isoform 2); 765..1390; Missing (in isoform 3)

3D Structural Models

Turn

75..77; 242..244; 395..397; 429..436; 496..498; 1172..1174; 1227..1230; 1239..1241; 1354..1358

Helix

25..30; 103..105; 205..208; 231..233; 239..241; 327..333; 367..374; 380..382; 387..390; 520..522; 526..529; 534..536; 548..550; 614..616; 1048..1050; 1055..1057; 1060..1066; 1067..1069; 1073..1075; 1118..1132; 1165..1170; 1178..1197; 1207..1209; 1224..1226; 1232..1234; 1247..1249; 1252..1257; 1262..1277; 1289..1291; 1292..1297; 1310..1319; 1324..1326; 1330..1342

Beta Strand

45..47; 52..58; 61..66; 69..74; 80..84; 89..91; 93..95; 97..99; 111..113; 119..123; 125..133; 135..139; 141..145; 155..160; 166..168; 173..175; 182..189; 192..199; 213..219; 247..255; 258..268; 272..274; 277..281; 284..286; 292..300; 312..314; 316..323; 341..349; 356..366; 383..385; 392..394; 418..422; 424..427; 439..447; 450..457; 462..466; 469..471; 476..480; 490..493; 501..506; 509..514; 539..541; 544..546; 552..554; 557..559; 564..574; 580..586; 589..592; 595..598; 602..605; 619..625; 633..641; 646..655; 658..663; 665..668; 674..681; 688..692; 698..702; 704..710; 718..726; 729..739; 1076..1087; 1090..1098; 1100..1102; 1104..1111; 1144..1146; 1149..1151; 1154..1158; 1161..1163; 1210..1212; 1218..1220; 1235..1237; 1244..1246; 1283..1287

3D Structure

Electron microscopy (5); NMR spectroscopy (1); X-ray crystallography (114)

Domain & Motif Annotations

Domain (CC)

The kinase domain is involved in SPSB1 binding.; DOMAIN: The beta-propeller Sema domain mediates binding to HGF.

Domain (FT)

27..515; Sema; 563..655; IPT/TIG 1; 657..739; IPT/TIG 2; 742..836; IPT/TIG 3; 1078..1345; Protein kinase

Region

1212..1390; Interaction with RANBP9; 1320..1359; Interaction with MUC20

Protein Families (2)

Protein kinase superfamily
Tyr protein kinase family

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Clinical Relevance9

Disease Involvement (6)

Cancer-related genesDeafnessDisease variantFDA approved drug targetsNon-syndromic deafnessProto-oncogene

Biomarker

Phase 1/2; Phase 2; Phase 1; Phase 3; Discontinued in Phase 2; Approved; Preclinical

Drug Targets

FDA approved drug targets

Drugs (101)

FORETINIB GEFITINIB SELUMETINIB TIVANTINIB TEPOTINIB CABOZANTINIB S-MALATE OSIMERTINIB GLESATINIB ANTI-MET MONOCLONAL ANTIBODY MIXTURE SYM015 CAPMATINIB CETUXIMAB ROCILETINIB EMIBETUZUMAB CHEMBL:CHEMBL546797 BMS-754807 BMS-777607 NULL CEP-11981 -SAR 125844.00 DACTOLISIB TEREVALEFIM AMG-208 PEMBROLIZUMAB EUCALYPTIN A MACROCARPAL B MET TYROSINE KINASE INHIBITOR SGX523 MITOGEN-ACTIVATED PROTEIN KINASE KINASE INHIBITOR BMS-794833 PF-04217903 SAVOLITINIB TRAMETINIB DIMETHYL SULFOXIDE OLEOCANTHAL EMB-01 TAS-115 VEMURAFENIB TELISOTUZUMAB ZM447439 C-MET INHIBITOR AMG 208 CRIZOTINIB CAPMATINIB HYDROCHLORIDE SITRAVATINIB MK-8033 MK-2461 GALLOCATECHIN GALLATE EMD-1204831 TELISOTUZUMAB VEDOTIN PF-562271 TEPOTINIB HYDROCHLORIDE BMS-698769 ALTIRATINIB NVP-TAE684 ONARTUZUMAB EPIGALLOCATECHIN-3-GALLATE CMX-2043 PD-0166285 SP-600125 YUANHUADINE LAPATINIB SU11274 BMS-817378 AMG-337 PAZOPANIB MERESTINIB PHA-665752 PALBOCICLIB CP-547632 ERLOTINIB SGX-523 JNJ-38877605 AMUVATINIB ANTI-C-MET MONOCLONAL ANTIBODY SAIT301 CHEMBL:CHEMBL1997335 MACROCARPAL A GOLVATINIB ENTRECTINIB BEPERMINOGENE PERPLASMID ANTI-MET/EGFR MONOCLONAL ANTIBODY LY3164530 TAMATINIB CHEMBL:CHEMBL399530 CRENOLANIB RITUXIMAB SNS-314 C-MET INHIBITOR MK2461 C-MET INHIBITOR AMG 337 PANITUMUMAB C-MET INHIBITOR ARRY-300 BPI-9016 ILORASERTIB TYROSOL SINAPATE CENISERTIB CYC-116 EPICATECHIN GALLATE NINGETINIB APRATOXIN F AMIVANTAMAB-VMJW LINIFANIB ANTI-EGFR MONOCLONAL ANTIBODY VEBRELTINIB BAY 61-3606 JNJ-7706621

Antibody (2)

CAB005282 HPA055607

Interaction Protein (6)

ENSG00000010017ENSG00000019991ENSG00000103423ENSG00000110395ENSG00000146648ENSG00000197122

Interaction Count

6

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
29889559	Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury.	Tau, p-tau, Aβ40, and Aβ42 were measured by ultrasensitive immunoassay in plasma and exosomes from 195 Veterans enrolled in the Chronic Effects of Neurotrauma Consortium Multicenter Observational Study.
37673813	Assessment of Risk Factors for Postoperative Delirium in Older Adults Who Underwent Spinal Surgery and Identifying Associated Biomarkers Using Exosomal Protein.	To discover the biomarkers, urine extracellular vesicles (EVs) were analyzed for tau, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), neurofilament light, and glial fibrillary acidic protein using digital immunoassay technology.
38257772	CSF Extracellular Vesicle Aβ42 and Tau/Aβ42 Ratio Are Associated with Cognitive Impairment in Older People with HIV.	Given the role of extracellular vesicles (EVs) in age-related neurological disorders, we investigated soluble and EV-associated Aβ42, total Tau, NFL, GFAP, ICAM-1, VCAM-1, and CRP in relation to cognitive impairment in PWH.

Entry name MET	UniProt ID P08581	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteinsRAS pathway related proteinsTransporters