Protein detail
TRFM
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Entry name TRFM | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) | Transmembrane count | Protein classification CD markersPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Protein Class (3)
CD markersPlasma proteinsPredicted intracellular proteins
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (7)
CD228FLJ38863MAP97MFI2MGC4856MTfMTF1
Gene Description
Melanotransferrin
Chromosome
3
Position
196980590-197029835
EVMP confidence score
0.25
Fluorescence & Localization3
Cell SpecificBrain excitatory neuronsSecretome LocationIntracellular and membraneSecretome FunctionTransport
Function & Pathway6
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Cellular Component (9)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence18
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | Yes |
| ecm | ecm | MatrixDB | Yes | No | No | No | Yes |
| ecm | ecm | OmniPath | Yes | No | No | No | Yes |
| extracellular | extracellular | LOCATE | No | No | No | No | Yes |
| extracellular | extracellular | OmniPath | No | No | No | No | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | No | Yes |
| intracellular | intracellular | OmniPath | No | No | No | No | Yes |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | No | Yes |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | Yes |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains13
Sequences
Length
738
Mass
80,215
Sequence
MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVTIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKMFDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAPLLPLLLPALAARLLPPAL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08582-1; Sequence=Displayed; Name=2; IsoId=P08582-2; Sequence=VSP_006557, VSP_006558
Alternative Sequence
238..302; GKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQRL -> ESPSRRQTWTRSEEEEGECPAHEEARRTMRSSAGQAWKWAPVHRPQDESDKGEFGKRAKSRDMLG (in isoform 2); 303..738; Missing (in isoform 2)
3D Structural Models
Turn
101..103; 137..140; 230..232; 268..270; 483..486; 664..667
Helix
30..45; 60..68; 79..87; 141..150; 160..167; 182..185; 209..218; 233..235; 250..252; 290..302; 316..318; 340..343; 346..355; 373..388; 403..411; 422..431; 487..495; 506..513; 529..532; 555..564; 577..580; 589..592; 596..598; 611..616; 635..649; 689..693; 695..705
Beta Strand
23..29; 52..56; 74..77; 91..98; 105..116; 129..132; 168..172; 186..188; 192..195; 223..229; 244..246; 253..255; 273..277; 280..287; 320..322; 331..334; 364..370; 392..399; 417..420; 435..442; 448..450; 452..458; 474..476; 514..518; 521..523; 546..548; 569..574; 599..602; 608..610; 619..621; 626..629; 655..657; 668..670; 677..681
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
23..357; Transferrin-like 1; 366..706; Transferrin-like 2
Region
20..30; Antigenic epitope
Protein Families
Transferrin family
Sequence Similarities
Belongs to the transferrin family.
Clinical Relevance4
Related Diseases
Biomarker
Phase 1
Drug Targets
Literature-reported target
Antibody