Protein detail
FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Entry name FCG3A | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Protein Class (8)
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (7)
- Disease related genes
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Transmembrane
209..229; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
CD16CD16aFCG3FcgammaRIIIaFCGR3FcGRIIIA
Gene Description
Fc gamma receptor IIIa
Chromosome
1
Position
161541759-161550968
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization4
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway8
Protein Function (7)
- Disease related genes
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
KEGG (9)
- hsa04145 Phagosome
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05322 Systemic lupus erythematosus
Reactome (11)
- R-hsa-1280218 adaptive immune system
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-9664407 parasite infection
Page 1 of 2
Canonical Pathways
M232 Pid ecadherin stabilization pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence42
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
Page 4 of 4Previous
Protein Complex Composition (3)
Sequence, Structure & Domains7
Sequences
Length
254
Mass
29,089
Sequence
MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK
3D Structural Models
Helix
81..83; 131..133; 164..166
Beta Strand
27..33; 35..38; 43..48; 51..54; 59..62; 65..68; 71..78; 85..91; 94..98; 100..105; 107..112; 116..119; 124..130; 136..143; 146..153; 157..161; 168..176; 179..182; 186..191
3D Structure
X-ray crystallography (14)
Domain & Motif Annotations
Domain (FT)
24..105; Ig-like C2-type 1; 107..189; Ig-like C2-type 2
Clinical Relevance6
Disease Involvement
FDA approved drug targets
Related Diseases (6)
Biomarker
Phase 2; Phase 1/2; Phase 1
Drug Targets
FDA approved drug targets
Drugs (54)
IL-18LIFFAS LIGANDPUROMYCINUBENIMEXPENICILLINCOMPOUND 7 [PMID: 34333981]RECOMBINANT EOTAXINEPOETIN ALFACIMETIDINEMUROMONAB-CD3RITUXIMABRECOMBINANT FLT3 LIGANDCETUXIMABCYCLOSPORINERECOMBINANT HUMAN STEM CELL FACTORTETRADECANOYLPHORBOL ACETATEAFM-13AT-9283PICIBANILDOXORUBICIN HYDROCHLORIDESODIUM CHLORIDEPROTEASE INHIBITORCYTARABINEVINCRISTINEH2O2ALDESLEUKINIMGATUZUMABPREDNISOLONEMARGETUXIMAB-CMKBANTI-THYMOCYTE GLOBULINTOCILIZUMABRECOMBINANT INTERLEUKIN-8THALIDOMIDEMAFOSFAMIDENULLDIMETHYL SULFOXIDEIMMUNOTHERAPEUTIC AGENTGELDANAMYCINBAY-985CHONDROITIN SULFATESIMMUNOSUPPRESSANTLACTULOSEINDOMETHACINPOLY ICHEPARINFENTANYL CITRATETESMILIFENEANGIOGENESIS INHIBITORMATRIX METALLOPROTEINASE INHIBITORCA19-9 ANTIGENGMA-161TOMIVOSERTIBCYCLOPHOSPHAMIDE ANHYDROUS
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |