Protein detail
FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Protein symbol FCG3A | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Low affinity immunoglobulin gamma Fc region receptor III-A (IgG Fc receptor III-A) (CD16-II) (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcgammaRIIIA) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)
Protein Class
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Disease related genes
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Transmembrane
209..229; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD16CD16aFCG3FcgammaRIIIaFCGR3FcGRIIIA
Gene Description
Fc gamma receptor IIIa
Chromosome
1
Position
161541759-161550968
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04145 Phagosome
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05140 Leishmaniasis
- KEGG:hsa05150 Staphylococcus aureus infection
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05322 Systemic lupus erythematosus
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-9664407 parasite infection
- R-hsa-2029485 role of phospholipids in phagocytosis
Canonical Pathways
M232 Pid ecadherin stabilization pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
254
Mass
29,089
Sequence
MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQVSFCLVMVLLFAVDTGLYFSVKTNIRSSTRDWKDHKFKWRKDPQDK
3D Structural Models
Helix
81..83; 131..133; 164..166
Beta Strand
27..33; 35..38; 43..48; 51..54; 59..62; 65..68; 71..78; 85..91; 94..98; 100..105; 107..112; 116..119; 124..130; 136..143; 146..153; 157..161; 168..176; 179..182; 186..191
3D Structure
X-ray crystallography (14)
Domain & Motif Annotations
Domain (FT)
24..105; Ig-like C2-type 1; 107..189; Ig-like C2-type 2
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 2; Phase 1/2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
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