Protein detail
ITA5
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Entry name ITA5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]
Protein Class (5)
Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Transporters:Accessory Factors Involved in Transport
Transmembrane
996..1021; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD49eFNRA
Gene Description
Integrin subunit alpha 5
Chromosome
12
Position
54395261-54419266
Supporting publications (n)
5
EVMP confidence score
0.25
Fluorescence & Localization6
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionEnzyme
Function & Pathway7
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- CD markers
- Transporters:Accessory Factors Involved in Transport
Cellular Component (15)
- GO:0001726 ruffle
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005925 focal adhesion
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0031410 cytoplasmic vesicle
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Molecular Function (8)
- GO:0001618 virus receptor activity
- GO:0005154 epidermal growth factor receptor binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005178 integrin binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0038023 signaling receptor activity
- GO:0043184 vascular endothelial growth factor receptor 2 binding
Biological Process (3)
KEGG (21)
- hsa03266 Virion - Herpesvirus
- KEGG:hsa04145 Phagosome
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
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Reactome (19)
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-1566977 fibronectin matrix formation
- R-hsa-9634597 gper1 signaling
- R-hsa-418555 g alpha s signalling events
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence74
Ligand-Receptor Signaling (71)
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| integrin | matrix_adhesion | Almen2009 | No | Yes | No | Yes | No |
| integrin | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37403840 |
Sequence, Structure & Domains12
Sequences
Length
1,049
Mass
114,536
Sequence
MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPPPPRVGGFNLDAEAPAVLSGPPGSFFGFSVEFYRPGTDGVSVLVGAPKANTSQPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVRAHGSSILACAPLYSWRTEKEPLSDPVGTCYLSTDNFTRILEYAPCRSDFSWAAGQGYCQGGFSAEFTKTGRVVLGGPGSYFWQGQILSATQEQIAESYYPEYLINLVQGQLQTRQASSIYDDSYLGYSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTILNGSDIRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVFPGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPQAPVDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGDKNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDLGNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILSKNLNNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQQLLYVTRVTGLNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQILKCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFKRSLPYGTAMEKAQLKPPATSDA
3D Structural Models
Turn
56..61; 181..184; 198..204; 294..300; 308..310; 549..555; 563..565
Helix
122..124; 226..229; 238..243; 265..267; 392..394; 479..481
Beta Strand
50..53; 62..67; 69..71; 75..80; 95..101; 102..104; 109..111; 125..130; 133..136; 144..149; 152..157; 161..163; 165..167; 175..180; 185..189; 193..196; 209..213; 219..223; 231..236; 249..251; 274..279; 282..286; 288..293; 302..306; 313..318; 320..324; 328..333; 335..339; 342..347; 351..353; 359..361; 364..368; 380..384; 396..400; 405..407; 409..414; 424..428; 432..434; 440..443; 458..464; 466..471; 473..478; 483..487; 492..503; 513..520; 522..532; 534..536; 538..548; 560..562; 566..577; 583..591; 600..602; 604..612; 614..616; 620..622; 629..631; 634..641
3D Structure
Electron microscopy (7); X-ray crystallography (6)
Domain & Motif Annotations
Repeat
43..108; FG-GAP 1; 128..188; FG-GAP 2; 192..245; FG-GAP 3; 259..311; FG-GAP 4; 312..377; FG-GAP 5; 378..437; FG-GAP 6; 441..504; FG-GAP 7
Motif
1024..1028; GFFKR motif
Region
877..907; Disordered; 1021..1028; Interaction with HPS5
Protein Families
Integrin alpha chain family
Sequence Similarities
Belongs to the integrin alpha chain family.
Clinical Relevance8
Disease Involvement
Cancer-related genes
Related Diseases (5)
Biomarker
Discontinued in Phase 1; Phase 1; Discontinued in Phase 2
Drugs (9)
Interaction Protein (3)
ENSG00000115414ENSG00000150093ENSG00000179526
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 24670152 | Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation. | No abstract available |
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No abstract available |
| 31753726 | Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location. | No abstract available |
| 32938681 | Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. | No abstract available |
| 36028467 | Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment. | No abstract available |