Protein detail
ADA2A
Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
Protein symbol ADA2A | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR)
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
48..71; Helical; Name=1; 86..107; Helical; Name=2; 121..144; Helical; Name=3; 168..181; Helical; Name=4; 209..232; Helical; Name=5; 389..413; Helical; Name=6; 422..443; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificretinaCell SpecificCone photoreceptor cellsBlood Cell Specificnon-classical monocyte
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0043025 neuronal cell body
- GO:0043235 receptor complex
- GO:0043679 axon terminus
- GO:0048787 presynaptic active zone membrane
- GO:0098691 dopaminergic synapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
Molecular Function
- GO:0004938 alpha2-adrenergic receptor activity
- GO:0005085 guanyl-nucleotide exchange factor activity
- GO:0005515 protein binding
- GO:0019901 protein kinase binding
- GO:0031692 alpha-1B adrenergic receptor binding
- GO:0031696 alpha-2C adrenergic receptor binding
- GO:0031996 thioesterase binding
- GO:0032795 heterotrimeric G-protein binding
- GO:0042803 protein homodimerization activity
- GO:0046982 protein heterodimerization activity
- GO:0051379 epinephrine binding
- GO:0051380 norepinephrine binding
Biological Process
KEGG
Reactome
- R-hsa-400042 adrenaline noradrenaline inhibits insulin secretion
- R-hsa-390696 adrenoceptors
- R-hsa-375280 amine ligand binding receptors
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-418597 g alpha z signalling events
- R-hsa-109582 hemostasis
- R-hsa-163685 integration of energy metabolism
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76009 platelet aggregation plug formation
- R-hsa-422356 regulation of insulin secretion
- R-hsa-372790 signaling by gpcr
- R-hsa-5683826 surfactant metabolism
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ADRA2A | GRK2 | P25098 | S | 312 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORHPRD | HPRD:7876239SIGNOR:7876239 |
| ADRA2A | GRK2 | P25098 | S | 313 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORHPRD | HPRD:7876239SIGNOR:7876239 |
| ADRA2A | GRK2 | P25098 | S | 311 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORHPRD | HPRD:7876239SIGNOR:7876239 |
| ADRA2A | GRK2 | P25098 | S | 314 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORHPRD | HPRD:19651622HPRD:7876239SIGNOR:7876239 |
| ADRA2A | PRKCD | Q05655 | S | 247 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNOR | SIGNOR:11732925 |
| ADRA2A | PRKCA | P17252 | S | 247 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ADRA2A | PRKCB | P05771 | S | 247 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ADRA2A | PRKCG | P05129 | S | 247 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| ADRA2A | PRKCE | Q02156 | S | 247 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA2A | P08913 | GNAI3 | P08754 | Yes | Yes | No | WangCui2007SIGNORCA1 | CA1:1849000SIGNOR:31160049 |
| ADA2A | P08913 | GNAO | P09471 | Yes | Yes | No | SIGNORHPRDCui2007HINTCA1Wang | HINT:36173843SIGNOR:31160049HINT:35245122HPRD:7887906HINT:16352729CA1:1849000HPRD:11732925 |
| ARBK1 | P25098 | ADA2A | P08913 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD-phos:7876239ProtMapper:19651622SIGNOR:7876239HPRD:7876239ProtMapper:7876239HPRD-phos:19651622KEA:7876239 |
| ADA2A | P08913 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA2A | P08913 | GNAI1 | P63096 | Yes | Yes | No | HPRDSIGNOR | HPRD:11732925SIGNOR:31160049 |
| KPCD | Q05655 | ADA2A | P08913 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | ProtMapper:11732925SIGNOR:11732925HPRD:11732925KEA:11732925 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
465
Mass
50,647
Sequence
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
3D Structural Models
Turn
209..211; 308..310; 351..353
Helix
49..75; 82..84; 85..99; 102..110; 118..151; 153..158; 162..180; 212..219; 221..242; 255..272; 278..296; 326..341; 344..350; 355..362; 367..377; 383..411; 412..414; 420..431; 433..444; 446..457
Beta Strand
45..47; 76..78; 111..113
3D Structure
Electron microscopy (13); NMR spectroscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
313..330; Basic and acidic residues
Region
242..368; Disordered
Protein Families
- G-protein coupled receptor 1 family
- Adrenergic receptor subfamily
- ADRA2A sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 3; Approved; Investigative; Phase 1; Terminated; Phase 2; Discontinued in Phase 2; IND submitted
Drugs
YOHIMBINEAJMALICINENULLNOREPINEPHRINEERGOLOID MESYLATES, USPLOFEXIDINEMEDETOMIDINENORTRIPTYLINEMIRTAZAPINERAUWOLSCINEDOPAMINESENREBOTASEOLANZAPINEBENZPHETAMINENAPHAZOLINE HYDROCHLORIDEESMIRTAZAPINE MALEATEFIPAMEZOLEBRIMONIDINEDEXTROAMPHETAMINE SULFATEAPRACLONIDINECGEN-856IDAZOXANNICERGOLINECLONIDINE HYDROCHLORIDEPHENTOLAMINEPHENYLPROPANOLAMINEESMIRTAZAPINETETRAHYDROZOLINE HYDROCHLORIDEEPINEPHRINE BITARTRATELOFEXIDINE HYDROCHLORIDEVASOACTIVE INTESTINAL PEPTIDEPHENOXYBENZAMINEAPRACLONIDINE HYDROCHLORIDETRAZODONEEPHEDRINEXYLOMETAZOLINEDOXAZOSIN MESYLATEDEXMEDETOMIDINE HYDROCHLORIDETIZANIDINE HYDROCHLORIDEMETHAMPHETAMINERAUWOLFIA SERPENTINA (USP)GUANABENZAR234960METHYLDOPA ANHYDROUSGUANFACINE HYDROCHLORIDEMIANSERINBETHANIDINEFADOLMIDINEERGOTAMINE TARTRATEEPHEDRINE HYDROCHLORIDERX821002LEVONORDEFRINDEBRISOQUINISOPROTERENOLAR244555MOXISYLYTEDIPIVEFRINPHENTOLAMINE MESYLATEEPINEPHRINEMETHYLDOPATE HYDROCHLORIDEOXYMETAZOLINE HYDROCHLORIDEDROXIDOPAMILNACIPRANGUANIDINE HYDROCHLORIDEAR291903LABETALOL HYDROCHLORIDENOREPINEPHRINE BITARTRATEMK-912MOXONIDINEAR305352ASENAPINEPHENOXYBENZAMINE HYDROCHLORIDECGEN-857MEPHENTERMINE SULFATEAR234958GUANABENZ ACETATEFADOLMIDINE HYDROCHLORIDECELIPROLOLDIPIVEFRIN HYDROCHLORIDEHYDROXYAMPHETAMINE HYDROBROMIDEPSEUDOEPHEDRINEPARDOPRUNOXSODIUM CHLORIDEMEPERIDINE HYDROCHLORIDEATENOLOLTOLAZOLINE HYDROCHLORIDEFENOLDOPAM MESYLATE