Protein detail
CSF1
Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit]
Entry name CSF1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit]
Protein Function (6)
- Predicted intracellular proteins
- RAS pathway related proteins
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Transmembrane
497..517; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificgdT-cellBlood Lineage Specificgranulocytes
Function & Pathway8
Protein Function (6)
- Predicted intracellular proteins
- RAS pathway related proteins
- Candidate cardiovascular disease genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Cellular Component (8)
Molecular Function (6)
Biological Process (3)
KEGG (12)
- hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04061 Viral protein interaction with cytokine and cytokine receptor
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04668 TNF signaling pathway
- KEGG:hsa05010 Alzheimer disease
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Reactome (9)
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-449836 other interleukin signaling
- R-hsa-597592 post translational protein modification
- R-hsa-381426 regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-449147 signaling by interleukins
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
Canonical Pathways (3)
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence75
Ligand-Receptor Signaling (66)
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | Cellinker | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | talklr | Yes | No | Yes | Yes | No |
| ligand | ligand | Cellinker | Yes | No | Yes | Yes | No |
| ligand | ligand | scConnect | Yes | No | Yes | Yes | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | Yes | No |
| ligand | ligand | Matrisome | Yes | No | Yes | Yes | No |
| ligand | ligand | CellCall | Yes | No | Yes | Yes | No |
Regulatory Interaction Network (3)
3 records.
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL34-CSF1R complex | CSF1RIL34 | P07333Q6ZMJ4 | 2:2 | ComplexPortalPDB | intact:EBI-56923748PDB:4dkdPDB:4DKD | 31940023300669571475529222483114 |
| Macrophage colony-stimulating factor-1 receptor-ligand complex | CSF1CSF1R | P07333P09603 | 2:2 | ComplexPortalPDB | PDB:4wrlintact:EBI-58999639PDB:4wrm | 14755292221534991871858130618643 |
| CSF1 | P09603 | 2 | PDB | PDB:3uf2PDB:1hmcPDB:5lxf | ||
| CBLCSF1SLA2 | P09603P22681Q9H6Q3 | 1:1:1 | CompleatCFinder | Compleat:HC5464 | ||
| CSF1IL34 | P09603Q6ZMJ4 | 0:0 | ICELLNET | 26095744 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37364689 |
Sequence, Structure & Domains11
Sequences
Length
554
Mass
60,179
Sequence
MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPVAGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGGSPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQTEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSALLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRRSPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILVLLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P09603-1; Sequence=Displayed; Name=2; IsoId=P09603-2; Sequence=VSP_001188; Name=3; IsoId=P09603-3; Sequence=VSP_001187
Alternative Sequence
182..479; Missing (in isoform 3); 365..480; Missing (in isoform 2)
3D Structural Models
Turn
72..74
Helix
37..41; 45..56; 78..95; 104..119; 120..122; 128..130; 142..162; 166..168; 172..176
Beta Strand
65..70; 135..140
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Compositional Bias
344..354; Low complexity; 404..433; Polar residues; 440..453; Basic and acidic residues; 545..554; Basic and acidic residues
Region
224..488; Disordered; 406..426; O-glycosylated at one site; 526..554; Disordered
Clinical Relevance3
Related Diseases (2)
Biomarker
Phase 1; Phase 2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37250483 | Extracellular Vesicle-associated GARP/TGFβ:LAP Mediates "Infectious" Allo-tolerance. | Here we test the hypothesis that, like CD81-associated "latent" IL35, the transforming growth factor (TGF)β:latency-associated peptide (LAP)/glycoprotein A repetitions predominant (GARP) complex was also tethered to small extracellular vesicles (sEVs), aka exosomes, produced by lymphocytes from allo-tolerized mice. |