Protein detail

PGFRB

Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

Protein symbol
PGFRB
UniProt ID
P09619
EVMP score
0.25
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Basic Information
Protein Names
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
  • FDA approved drug targets:Biotech drugs
Transmembrane
533..553; Helical
Transmembrane Count
1
Ensembl
ENSG00000113721
Entrez Gene Symbol
PDGFRB
Gene Synonym
CD140bJTK12PDGFRPDGFR1
Gene Description
Platelet derived growth factor receptor beta
Chromosome
5
Position
150113839-150155872
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificPodocytes
Function & Pathway
Protein Function
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • CD markers
  • RAS pathway related proteins
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:Tyr protein kinases
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
  • M226 Pid vegfr1 pathway
  • M193 Pid nephrin neph1 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

88 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PDGFRBGRK2P25098S1,104phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPKEAphosphoELMPhosphoSitephosphoELM:15271984KEA:15271984
PDGFRBPTPN1P18031Y751dephosphorylationSIGNORDEPODDEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675
PDGFRBPTPN1P18031Y1,021dephosphorylationSIGNORDEPODDEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675
PDGFRBPTPN1P18031Y1,009dephosphorylationSIGNORDEPODDEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675
PDGFRBPTPN1P18031Y740dephosphorylationSIGNORDEPODDEPOD:9355745DEPOD:7693671SIGNOR:7545675DEPOD:7545675
PDGFRBPTPN1P18031Y771dephosphorylationHPRDSIGNORDEPODDEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675HPRD:7545675
PDGFRBPTPN1P18031Y716dephosphorylationSIGNORSIGNOR:18567737
PDGFRBPTPN1P18031Y716phosphorylationNCI-PID_ProtMapperSIGNOR_ProtMapperProtMapperProtMapper:18567737ProtMapper:12424235
PDGFRBPTPN1P18031Y1,021phosphorylationNCI-PID_ProtMapperSIGNOR_ProtMapperKEAProtMapperKEA:7876130ProtMapper:18567737ProtMapper:7545675ProtMapper:12424235
PDGFRBPTPN1P18031Y581phosphorylationNCI-PID_ProtMapperProtMapperProtMapper:12424235
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Ligand-Receptor Signaling

67 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularHPMRNoNoNoYesNo
extracellularextracellularOmniPathNoNoNoYesNo
intracellularintracellularLOCATENoNoNoYesNo
intracellularintracellularComPPINoNoNoYesNo
intracellularintracellularGO_IntercellNoNoNoYesNo
intracellularintracellularUniProt_locationNoNoNoYesNo
intracellularintracellularOmniPathNoNoNoYesNo
cell_adhesioncell_adhesionCellinkerYesYesNoYesNo
matrix_adhesionmatrix_adhesionCellinkerNoYesNoYesNo
adhesionadhesionOmniPathYesYesNoYesNo
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Regulatory Interaction Network

38 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PGFRBP09619ABL2P42684YesYesNoPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:34144039PhosphoSite:15735735PhosphoSite:34144039
ABL2P42684PGFRBP09619YesYesYesPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSPIKE_LCSPIKEPhosphoSite_ProtMapperSIGNOR:19275932SPIKE_LC:19275932SPIKE:19275932
ABL1P00519PGFRBP09619YesYesYesSPIKEWangPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperSPIKE_LCSPIKE_LC:14993293PhosphoSite:19275932SPIKE_LC:19275932SPIKE_LC:20841568SPIKE:14993293ProtMapper:19275932SPIKE:19275932SPIKE:20841568SIGNOR:19275932
PGFRBP09619ABL1P00519YesYesNoREACH_ProtMapperSIGNORProtMapperSIGNOR:19275932ProtMapper:19275932
PGFRBP09619PGFRAP16234YesYesNoWangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperHPRDHINTSignaLink3BioGRIDIntActSPIKE_LCLit-BM-17PhosphoSitePhosphoSite_ProtMapperPhosphoSite:7523122SignaLink3:7523122IntAct:11331882BioGRID:2542288HPRD:1847074Lit-BM-17:11331882HPRD:2161888SignaLink3:21071413SignaLink3:2542288Lit-BM-17:2542288HINT:11331882HPRD:7523122Lit-BM-17:7523122SignaLink3:23331499SPIKE_LC:16189514HPRD:2542288HINT:33961781HINT:2542288
PDGFCQ9NRA1PGFRBP09619YesYesNoFantom5_LRdbCellTalkDBiTALKtalklrconnectomeDB2020SignaLink3Baccin2019WangLRdbSTRING_talklrEMBRACECellCallSignaLink3:11297552Baccin2019:19795151SignaLink3:23331499CellTalkDB:32196115connectomeDB2020:19795151
PGFRBP09619SHC1P29353YesYesNoWangPhosphoPointSIGNORHPRDPhosphoSite_KEAKEAACSNSignaLink3Li2012SPIKE_LCKEA:10896916ACSN:17673906KEA:9927207KEA:9685404KEA:9446569KEA:9710204KEA:10764799ACSN:17496910KEA:10921922KEA:11075717SignaLink3:8195171KEA:10816433KEA:9741627HPRD:8195171ACSN:12767520KEA:15592455SignaLink3:23331499SIGNOR:8195171KEA:9121430SignaLink3:21071413KEA:12522270KEA:8702728KEA:8610109KEA:12237775SPIKE_LC:16713569KEA:10482988
PGFRBP09619FERP16591YesYesNoWangSignaLink3SignaLink3:23589302
PGFRBP09619PLCG1P19174YesYesNoKEGG-MEDICUSSIGNORProtMapperHINTPhosphoSite_KEASignaLink3Li2012DIPLit-BM-17HPRDCui2007CA1IntActWangPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperPhosphoPointKEABioGRIDSPIKE_LCDIP:23063561DIP:7486683Lit-BM-17:1396585HINT:15641795SIGNOR:7535778KEA:16126727KEA:16153436Lit-BM-17:8443409KEA:8885868HINT:23063561HINT:1396585Lit-BM-17:23397142Lit-BM-17:7486683ProtMapper:15212693KEA:17081983IntAct:23397142KEA:12601080KEA:7682059CA1:2472219KEA:15144186IntAct:23063561KEA:8657103KEA:1689310KEA:15592455SignaLink3:23331499IntAct:11896612Lit-BM-17:15641795KEA:1708307HINT:7678051HPRD:8443409SignaLink3:8443409SignaLink3:7535778HINT:11896612IntAct:1396585Lit-BM-17:11896612SPIKE_LC:16713569BioGRID:8443409IntAct:15641795KEA:16038803
PGFRBP09619PTN11Q06124YesYesNoHPRD_MIMPSIGNORProtMapperdbPTMHINTPhosphoSite_KEASignaLink3phosphoELM_KEALi2012Lit-BM-17PhosphoNetworksHPRDCui2007CA1IntActWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LCHPRD-phosCA1:8226787phosphoELM:8041791KEA:16094384HPRD:8041791dbPTM:19534553IntAct:8183548SignaLink3:7691811HINT:23922991SPIKE_LC:16189514SignaLink3:11266449KEA:8622870Lit-BM-17:12614164Lit-BM-17:23397142HPRD:12681492ProtMapper:8041791HINT:7691811SIGNOR:8041791HINT:11266449Lit-BM-17:8119896IntAct:8538796dbPTM:18083107HINT:12614164IntAct:7530043HINT:8119896HINT:7688466IntAct:23397142KEA:12721296IntAct:7688466KEA:8959326Lit-BM-17:11266449dbPTM:19690332KEA:11684012SignaLink3:23331499CA1:7688466Lit-BM-17:7688466dbPTM:17287340KEA:12522270HPRD:7691811dbPTM:16094384KEA:8041791Lit-BM-17:7530043HINT:8538796KEA:12531430BioGRID:7691811Lit-BM-17:8538796IntAct:12614164HPRD-phos:8041791Lit-BM-17:7691811Lit-BM-17:8183548HINT:7530043IntAct:8119896
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Protein Complex Composition

6 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PDGF receptor beta - PDGF-AB complexPDGFAPDGFBPDGFRBP01127P04085P096191:1:1ComplexPortalintact:EBI-90838101475529215207811
PDGF receptor beta - PDGF-DD complexPDGFDPDGFRBP09619Q9GZP01:1ComplexPortalintact:EBI-9085280113318821475529215207811
PDGFB-PDGFRB complexPDGFBPDGFRBP01127P096192:2CORUMComplexPortalPDBintact:EBI-9080507PDB:3mjgCORUM:641376791131475529215207811
Sh3kbp1-Cblb-Pdgfrb complexCBLBPDGFRBSH3KBP1P09619Q13191Q96B971:1:1CompleatCompleat:HC315212177062
PDGFRBP096192PDBPDB:2l6w
PDGFRBPIK3R1P09619P279862:2PDBPDB:2iuiPDB:1h9o

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry137446098
Sequence, Structure & Domains

Sequences

Length
1,106
Mass
123,968
Sequence
MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09619-1; Sequence=Displayed; Name=2; IsoId=P09619-2; Sequence=VSP_056008, VSP_056009
Alternative Sequence
311..336; VESGYVRLLGEVGTLQFAELHRSRTL -> RAATCGSWERWAHYNLLSCIGAGHCR (in isoform 2); 337..1106; Missing (in isoform 2)

3D Structural Models

Turn
175..177; 267..270; 296..299
Helix
92..94; 132..135; 530..556
Beta Strand
40..43; 50..58; 61..64; 70..75; 81..87; 96..101; 114..119; 136..141; 145..147; 158..164; 178..181; 185..194; 197..200; 204..208; 217..221; 223..226; 231..239; 241..248; 252..255; 261..265; 271..280; 287..295; 300..311
3D Structure
NMR spectroscopy (3); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias
1043..1060; Polar residues; 1066..1088; Acidic residues
Domain (FT)
33..120; Ig-like C2-type 1; 129..210; Ig-like C2-type 2; 214..309; Ig-like C2-type 3; 331..403; Ig-like C2-type 4; 416..524; Ig-like C2-type 5; 600..962; Protein kinase
Region
1019..1106; Disordered
Protein Families
  • Protein kinase superfamily
  • Tyr protein kinase family
  • CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Acute diabete complicationAlzheimer diseaseGram-positive bacterial infectionIntracranial injuryLiver cancerLung cancerMultiple myelomaMyelodysplastic syndromeRenal cell carcinomaSolid tumour/cancerThrombocytopenia
Biomarker
Approved; Phase 1/2; Investigative; Phase 3; Phase 2
Drug Targets
FDA approved drug targets
Drugs
IMATINIBVATALANIBSORAFENIBNULLBAFETINIBRG-1530DASATINIB ANHYDROUSNINTEDANIB ESYLATEORANTINIBPAZOPANIBVANDETANIBBARASERTIB-HQPAX-82FLUOROURACILBECAPLERMINTELATINIBREGORAFENIBMK-2461TANDUTINIBTG100-801AXITINIBXL820MOTESANIBXL999SUNITINIBCEDIRANIBNILOTINIBAST-487CENISERTIBVARGATEFPP2MASITINIBREBASTINIBJI-101BEVACIZUMAB-AWWBRINUCUMABCP-547632IRINOTECAN HYDROCHLORIDEAMUVATINIBDOVITINIBILORASERTIBXL-820BARASERTIBNVP-TAE684QUIZARTINIBSOTRASTAURINLEUCOVORIN CALCIUMPD-0166285ANLOTINIBFORETINIBXL-999PONATINIBENMD-981693SERALUTINIBLINIFANIBFAMITINIBCM-082CRENOLANIBMIDOSTAURINPEGPLERANIB SODIUMPAZOPANIB HYDROCHLORIDEPUQUITINIBDORAMAPIMODLENVATINIBPETROSIOL AHESPERADINDOVITINIB LACTATERIPRETINIBROMIPLOSTIMCEP-2563TAK-593TAMATINIBSNS-314TOZASERTIBPF-562271TRAPIDILRABEPRAZOLESU-014813CDP-860TIVOZANIB HYDROCHLORIDECHEMBL:CHEMBL546797
Antibody
CAB003842CAB018144HPA028499
Interaction Protein
ENSG00000100311ENSG00000109062ENSG00000124181ENSG00000145675ENSG00000171862ENSG00000179295
Interaction Count
6
Interaction Dataset
intact_biogrid