Protein detail
PGFRB
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Protein symbol PGFRB | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters |
Basic Information
Protein Names
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Protein Function
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
533..553; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD140bJTK12PDGFRPDGFR1
Gene Description
Platelet derived growth factor receptor beta
Chromosome
5
Position
150113839-150155872
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificPodocytes
Function & Pathway
Protein Function
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0031410 cytoplasmic vesicle
- GO:0043202 lysosomal lumen
- GO:0043231 intracellular membrane-bounded organelle
- GO:0043235 receptor complex
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004992 platelet activating factor receptor activity
- GO:0005017 platelet-derived growth factor receptor activity
- GO:0005019 platelet-derived growth factor beta-receptor activity
- GO:0005096 GTPase activator activity
- GO:0005102 signaling receptor binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019899 enzyme binding
- GO:0019901 protein kinase binding
- GO:0038085 vascular endothelial growth factor binding
- GO:0048407 platelet-derived growth factor binding
- GO:0160185 phospholipase C activator activity
Biological Process
KEGG
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04540 Gap junction
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05215 Prostate cancer
- KEGG:hsa05218 Melanoma
- KEGG:hsa05230 Central carbon metabolism in cancer
- KEGG:hsa05231 Choline metabolism in cancer
Reactome
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-186763 downstream signal transduction
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-186797 signaling by pdgf
- R-hsa-9006934 signaling by receptor tyrosine kinases
Canonical Pathways
- M226 Pid vegfr1 pathway
- M193 Pid nephrin neph1 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
88 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PDGFRB | GRK2 | P25098 | S | 1,104 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPKEAphosphoELMPhosphoSite | phosphoELM:15271984KEA:15271984 |
| PDGFRB | PTPN1 | P18031 | Y | 751 | dephosphorylation | SIGNORDEPOD | DEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675 |
| PDGFRB | PTPN1 | P18031 | Y | 1,021 | dephosphorylation | SIGNORDEPOD | DEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675 |
| PDGFRB | PTPN1 | P18031 | Y | 1,009 | dephosphorylation | SIGNORDEPOD | DEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675 |
| PDGFRB | PTPN1 | P18031 | Y | 740 | dephosphorylation | SIGNORDEPOD | DEPOD:9355745DEPOD:7693671SIGNOR:7545675DEPOD:7545675 |
| PDGFRB | PTPN1 | P18031 | Y | 771 | dephosphorylation | HPRDSIGNORDEPOD | DEPOD:9355745SIGNOR:7545675SIGNOR:18567737DEPOD:7693671DEPOD:7545675HPRD:7545675 |
| PDGFRB | PTPN1 | P18031 | Y | 716 | dephosphorylation | SIGNOR | SIGNOR:18567737 |
| PDGFRB | PTPN1 | P18031 | Y | 716 | phosphorylation | NCI-PID_ProtMapperSIGNOR_ProtMapperProtMapper | ProtMapper:18567737ProtMapper:12424235 |
| PDGFRB | PTPN1 | P18031 | Y | 1,021 | phosphorylation | NCI-PID_ProtMapperSIGNOR_ProtMapperKEAProtMapper | KEA:7876130ProtMapper:18567737ProtMapper:7545675ProtMapper:12424235 |
| PDGFRB | PTPN1 | P18031 | Y | 581 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:12424235 |
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Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Kirouac2010 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
38 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PGFRB | P09619 | GRB2 | P62993 | Yes | Yes | No | WangKEGG-MEDICUSPhosphoPointSIGNORLi2012HPRDHINTBioGRIDDIPSPIKE_LC | DIP:7486683HINT:9362449HPRD:7935391SIGNOR:7935391BioGRID:7935391SPIKE_LC:16713569HINT:7935391 |
| PPAC | P24666 | PGFRB | P09619 | Yes | No | Yes | SIGNORProtMapperDEPODKinexus_KEAKEASIGNOR_ProtMapper | KEA:7876130SIGNOR:12149261KEA:1691440ProtMapper:12149261DEPOD:12149261 |
| PGFRB | P09619 | ACK1 | Q07912 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperInnateDBPhosphoSite_ProtMapper | SIGNOR:25257795InnateDB:19815557 |
| PGFRB | P09619 | ARBK1 | P25098 | Yes | Yes | No | SIGNOR | SIGNOR:15994317 |
| ARBK1 | P25098 | PGFRB | P09619 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoPointSIGNORPhosphoSite_KEAKinexus_KEAKEAphosphoELM_KEAphosphoELM | SIGNOR:15271984phosphoELM:15271984KEA:15271984 |
| PGFRB | P09619 | GRK5 | P34947 | Yes | Yes | No | iPTMnetSIGNOR | SIGNOR:19092051 |
| PGFRB | P09619 | FAK1 | Q05397 | Yes | Yes | No | WangPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperHPRDLi2012SIGNOR_ProtMapperPhosphoSite_ProtMapperSPIKE_LC | SIGNOR:20802513SPIKE_LC:16713569ProtMapper:20802513HPRD:10806474 |
| CBL | P22681 | PGFRB | P09619 | Yes | No | Yes | HPRDWangSIGNORACSN | SIGNOR:10347229ACSN:10514377ACSN:17635922SIGNOR:10514377HPRD:10514377 |
| PGFRB | P09619 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:33139573 |
| PTPRG | P23470 | PGFRB | P09619 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PDGF receptor beta - PDGF-AB complex | PDGFAPDGFBPDGFRB | P01127P04085P09619 | 1:1:1 | ComplexPortal | intact:EBI-9083810 | 1475529215207811 |
| PDGF receptor beta - PDGF-DD complex | PDGFDPDGFRB | P09619Q9GZP0 | 1:1 | ComplexPortal | intact:EBI-9085280 | 113318821475529215207811 |
| PDGFB-PDGFRB complex | PDGFBPDGFRB | P01127P09619 | 2:2 | CORUMComplexPortalPDB | intact:EBI-9080507PDB:3mjgCORUM:6413 | 76791131475529215207811 |
| Sh3kbp1-Cblb-Pdgfrb complex | CBLBPDGFRBSH3KBP1 | P09619Q13191Q96B97 | 1:1:1 | Compleat | Compleat:HC3152 | 12177062 |
| PDGFRB | P09619 | 2 | PDB | PDB:2l6w | ||
| PDGFRBPIK3R1 | P09619P27986 | 2:2 | PDB | PDB:2iuiPDB:1h9o |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37446098 |
Sequence, Structure & Domains
Sequences
Length
1,106
Mass
123,968
Sequence
MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09619-1; Sequence=Displayed; Name=2; IsoId=P09619-2; Sequence=VSP_056008, VSP_056009
Alternative Sequence
311..336; VESGYVRLLGEVGTLQFAELHRSRTL -> RAATCGSWERWAHYNLLSCIGAGHCR (in isoform 2); 337..1106; Missing (in isoform 2)
3D Structural Models
Turn
175..177; 267..270; 296..299
Helix
92..94; 132..135; 530..556
Beta Strand
40..43; 50..58; 61..64; 70..75; 81..87; 96..101; 114..119; 136..141; 145..147; 158..164; 178..181; 185..194; 197..200; 204..208; 217..221; 223..226; 231..239; 241..248; 252..255; 261..265; 271..280; 287..295; 300..311
3D Structure
NMR spectroscopy (3); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
1043..1060; Polar residues; 1066..1088; Acidic residues
Domain (FT)
33..120; Ig-like C2-type 1; 129..210; Ig-like C2-type 2; 214..309; Ig-like C2-type 3; 331..403; Ig-like C2-type 4; 416..524; Ig-like C2-type 5; 600..962; Protein kinase
Region
1019..1106; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Biomarker
Approved; Phase 1/2; Investigative; Phase 3; Phase 2
Drug Targets
FDA approved drug targets
Drugs
IMATINIBVATALANIBSORAFENIBNULLBAFETINIBRG-1530DASATINIB ANHYDROUSNINTEDANIB ESYLATEORANTINIBPAZOPANIBVANDETANIBBARASERTIB-HQPAX-82FLUOROURACILBECAPLERMINTELATINIBREGORAFENIBMK-2461TANDUTINIBTG100-801AXITINIBXL820MOTESANIBXL999SUNITINIBCEDIRANIBNILOTINIBAST-487CENISERTIBVARGATEFPP2MASITINIBREBASTINIBJI-101BEVACIZUMAB-AWWBRINUCUMABCP-547632IRINOTECAN HYDROCHLORIDEAMUVATINIBDOVITINIBILORASERTIBXL-820BARASERTIBNVP-TAE684QUIZARTINIBSOTRASTAURINLEUCOVORIN CALCIUMPD-0166285ANLOTINIBFORETINIBXL-999PONATINIBENMD-981693SERALUTINIBLINIFANIBFAMITINIBCM-082CRENOLANIBMIDOSTAURINPEGPLERANIB SODIUMPAZOPANIB HYDROCHLORIDEPUQUITINIBDORAMAPIMODLENVATINIBPETROSIOL AHESPERADINDOVITINIB LACTATERIPRETINIBROMIPLOSTIMCEP-2563TAK-593TAMATINIBSNS-314TOZASERTIBPF-562271TRAPIDILRABEPRAZOLESU-014813CDP-860TIVOZANIB HYDROCHLORIDECHEMBL:CHEMBL546797
Interaction Protein
ENSG00000100311ENSG00000109062ENSG00000124181ENSG00000145675ENSG00000171862ENSG00000179295
Interaction Count
6
Interaction Dataset
intact_biogrid