Protein detail
CD3G
T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
Protein symbol CD3G | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
Protein Class
CD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
117..137; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD3-GAMMACD3GAMMA
Gene Description
CD3 gamma subunit of T-cell receptor complex
Chromosome
11
Position
118344344-118355161
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04640 Hematopoietic cell lineage
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04660 T cell receptor signaling pathway
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05162 Measles
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-8856825 cargo recognition for clathrin mediated endocytosis
- R-hsa-8856828 clathrin mediated endocytosis
- R-hsa-389948 co inhibition by pd 1
- R-hsa-202424 downstream tcr signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-202433 generation of second messenger molecules
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-199991 membrane trafficking
- R-hsa-9664407 parasite infection
- R-hsa-202427 phosphorylation of cd3 and tcr zeta chains
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-2029485 role of phospholipids in phagocytosis
- R-hsa-202403 tcr signaling
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
20 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD3G | SRC | P12931 | Y | 160 | phosphorylation | Li2012Reactome_ProtMapperProtMapper | |
| CD3G | SRC | P12931 | Y | 171 | phosphorylation | Li2012Reactome_ProtMapperProtMapper | |
| CD3G | PRKCA | P17252 | S | 145 | phosphorylation | PhosphoSite | |
| CD3G | PRKCA | P17252 | S | 148 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| CD3G | PRKCB | P05771 | S | 148 | phosphorylation | MIMPKEAphosphoELM_MIMPPhosphoSite_MIMP | KEA:17570479 |
| CD3G | PRKCB | P05771 | S | 145 | phosphorylation | KEA | KEA:17570479 |
| CD3G | PRKCG | P05129 | S | 148 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CD3G | PRKCD | Q05655 | S | 148 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CD3G | PRKCE | Q02156 | S | 148 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CD3G | LYN | P07948 | Y | 160 | phosphorylation | Reactome_ProtMapperProtMapper |
Page 1 of 2Next
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
| immune_cell | receptor | HPMR | No | Yes | No | Yes | No |
| t_cell_gamma_immune_cell | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
Page 1 of 4Next
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CD3G | P09693 | CD3E | P07766 | Yes | No | No | WangNetPathHPRDHINTSignaLink3SPIKE_LCSPIKETCRcuration_SignaLink3 | SPIKE_LC:2138083HINT:35271814HINT:38657677HINT:35985289SignaLink3:23109003HINT:20890284NetPath:2138083HINT:37100770HPRD:2138083SPIKE:2138083HINT:2138083SignaLink3:15084594HINT:31461748 |
| LCK | P06239 | CD3G | P09693 | Yes | Yes | No | WangSIGNOR | SIGNOR:2470098 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
182
Mass
20,469
Sequence
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGKMIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLFAEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLRRN
3D Structural Models
Turn
26..28
Helix
77..79; 112..135
Beta Strand
31..33; 38..46; 50..57; 60..68; 72..76; 82..92; 97..102; 106..109
3D Structure
Electron microscopy (28); X-ray crystallography (2)
Domain & Motif Annotations
Motif
153..154; Di-leucine motif
Domain (CC)
A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
Domain (FT)
37..94; Ig-like; 149..177; ITAM
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 2; Phase 1/2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
TEBENTAFUSPANTI-CD3 MONOCLONAL ANTIBODYMUROMONAB-CD3MEDI-565SOLITOMABGLOFITAMABELRANATAMABFBT-A05FORALUMABMOSUNETUZUMABANTI-GPA33/CD3 MONOCLONAL ANTIBODY MGD007CATUMAXOMABTALQUETAMABTEPLIZUMABVISILIZUMABERTUMAXOMABAFM-11EPCORITAMABODRONEXTAMABFLOTETUZUMABIMC-GP100TECLISTAMAB-CQYVOTELIXIZUMABBLINATUMOMAB