Protein detail

FGR

Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Entry name FGR	UniProt ID P09769	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Protein Class (5)

Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Ensembl

ENSG00000000938

Entrez Gene Symbol

FGR

Gene Synonym (3)

c-fgrp55c-fgrSRC2

Gene Description

FGR proto-oncogene, Src family tyrosine kinase

Chromosome

Position

27612064-27635185

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization5

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive CD8 T-cell

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Cellular Component (11)

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Molecular Function (9)

Biological Process (3)

KEGG

hsa04062 Chemokine signaling pathway

Reactome (12)

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Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence56

Enzyme-Mediated Modification (21)

21 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGR	MATK	P42679	Y	412	phosphorylation	PhosphoNetworks
FGR	TYRO3	Q06418	Y	34	phosphorylation	PhosphoNetworks
FGR	TYRO3	Q06418	Y	523	phosphorylation	PhosphoNetworks
FGR	PTK2B	Q14289	Y	180	phosphorylation	PhosphoNetworks
FGR	PTK2B	Q14289	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper
FGR	GNAI2	P04899	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:11160627
FGR	PTPN13	Q12923	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:11983165
FGR	CD244	Q9BZW8	Y	412	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:22238634
FGR	CD226	Q15762	Y	412	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:22238634
FGR	FYN	P06241	Y	412	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling (10)

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (22)

22 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGR	P09769	SHC1	P29353	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:10329689
FGR	P09769	PAXI	P49023	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9636140
FGR	P09769	FAK1	Q05397	Yes	Yes	No	WangTCRcuration_SignaLink3phosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPiPTMnetSIGNORProtMapperHPRDSignaLink3SIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:29743287 ProtMapper:12590707 PhosphoSite:16510472 SignaLink3:23109003 PhosphoSite:12754219 PhosphoSite:12408869 PhosphoSite:22751010 PhosphoSite:12531888 PhosphoSite:15077193 PhosphoSite:34858503 SignaLink3:12495636 PhosphoSite:26710849 PhosphoSite:22761432 PhosphoSite:12023386 PhosphoSite:14603053 PhosphoSite:18676832 PhosphoSite:15389641 PhosphoSite:26068982 PhosphoSite:14572662 PhosphoSite:26530902 PhosphoSite:33715263 PhosphoSite:14978737 PhosphoSite:12087088 PhosphoSite:24858039 PhosphoSite:27270311 PhosphoSite:28692661 ProtMapper:11369622 PhosphoSite:15316068 PhosphoSite:32051585 PhosphoSite:8824286 ProtMapper:15728464 SignaLink3:10593973 PhosphoSite:24608426 PhosphoSite:12659633 PhosphoSite:33674746 PhosphoSite:11891289 PhosphoSite:14610060 PhosphoSite:34237080 PhosphoSite:11438458 PhosphoSite:15126359 PhosphoSite:10821872 PhosphoSite:11331870 SignaLink3:9148935 SignaLink3:7529876 PhosphoSite:28377405 ProtMapper:12387730 PhosphoSite:32049010 SIGNOR:12387730 PhosphoSite:15611137 PhosphoSite:20160475 PhosphoSite:20180147 PhosphoSite:7597091 PhosphoSite:8051157 PhosphoSite:17234784 PhosphoSite:11035755 PhosphoSite:11857088 PhosphoSite:34161758 PhosphoSite:15800067 ProtMapper:10753828 PhosphoSite:24655477 ProtMapper:15561106 PhosphoSite:19962670 PhosphoSite:27790061 HPRD:12387730
FGR	P09769	FAK2	Q14289	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:12495636 SignaLink3:10593973 SignaLink3:7529876
FAK2	Q14289	FGR	P09769	Yes	Yes	No	PhosphoNetworksNCI-PID_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9148935
FGR	P09769	P85A	P27986	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:10488096 SignaLink3:22880054 SignaLink3:11526404 SignaLink3:23109003 SignaLink3:21780115 SignaLink3:15032589
FGR	P09769		Q96EV4	Yes	No	No	SignaLink3TCRcuration_SignaLink3	SignaLink3:10488096 SignaLink3:22880054 SignaLink3:11526404 SignaLink3:23109003 SignaLink3:21780115 SignaLink3:15032589
GNAI1	P63096	FGR	P09769	Yes	Yes	No	SignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9722546 SignaLink3:10753828 SignaLink3:11007482
GNAI2	P04899	FGR	P09769	Yes	Yes	No	NCI-PID_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3	SignaLink3:10753828 ProtMapper:11160627 SignaLink3:23109003 SignaLink3:11007482 SignaLink3:9722546
GNAI3	P08754	FGR	P09769	Yes	No	No	SignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9722546 SignaLink3:10753828 SignaLink3:11007482

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CDK14 FGR	O94921 P09769	0:0	hu.MAPhu.MAP2
	FGR	P09769	2	PDB	PDB:7uy0

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	38113368

Sequence, Structure & Domains10

Sequences

Length

529

Mass

59,479

Sequence

MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT

3D Structural Models

Turn

120..122; 189..191; 283..285; 514..516

Helix

130..132; 139..141; 151..158; 219..228; 260..262; 300..310; 342..345; 349..352; 356..375; 385..387; 392..394; 403..406; 422..424; 427..432; 437..452; 464..472; 485..494; 499..501; 505..513

Beta Strand

82..86; 92..95; 103..108; 112..119; 125..129; 133..135; 167..172; 174..176; 180..188; 192..202; 204..206; 208..211; 216..218; 231..235; 249..252; 263..271; 273..282; 286..293; 321..325; 327..329; 331..334; 388..390; 396..398; 407..412; 522..524

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

77..138; SH3; 144..241; SH2; 263..516; Protein kinase

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
SRC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Clinical Relevance6

Disease Involvement

Proto-oncogene

Antibody

HPA002024

Interaction Protein

ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications6

PMID	Title	Abstract
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38354507	Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No abstract available