Protein detail
FGR
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Entry name FGR | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count | Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Protein Class (5)
Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
c-fgrp55c-fgrSRC2
Gene Description
FGR proto-oncogene, Src family tyrosine kinase
Chromosome
1
Position
27612064-27635185
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive CD8 T-cell
Function & Pathway
Protein Function (6)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component (11)
- GO:0005576 extracellular region
- GO:0005743 mitochondrial inner membrane
- GO:0005758 mitochondrial intermembrane space
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0016235 aggresome
- GO:0032587 ruffle membrane
- GO:0034774 secretory granule lumen
Page 1 of 2
Molecular Function (9)
- GO:0001784 phosphotyrosine residue binding
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019901 protein kinase binding
- GO:0034987 immunoglobulin receptor binding
- GO:0034988 Fc-gamma receptor I complex binding
Biological Process (3)
Reactome (12)
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9664407 parasite infection
Page 1 of 2
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence56
Enzyme-Mediated Modification (21)
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FGR | MATK | P42679 | Y | 412 | phosphorylation | PhosphoNetworks | |
| FGR | TYRO3 | Q06418 | Y | 34 | phosphorylation | PhosphoNetworks | |
| FGR | TYRO3 | Q06418 | Y | 523 | phosphorylation | PhosphoNetworks | |
| FGR | PTK2B | Q14289 | Y | 180 | phosphorylation | PhosphoNetworks | |
| FGR | PTK2B | Q14289 | Y | 412 | phosphorylation | NCI-PID_ProtMapperProtMapper | |
| FGR | GNAI2 | P04899 | Y | 412 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11160627 |
| FGR | PTPN13 | Q12923 | Y | 412 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11983165 |
| FGR | CD244 | Q9BZW8 | Y | 412 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22238634 |
| FGR | CD226 | Q15762 | Y | 412 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22238634 |
| FGR | FYN | P06241 | Y | 412 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (22)
22 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FGR | P09769 | LOX5 | P09917 | Yes | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:24860872 | ||
| FGR | P09769 | RIPK2 | O43353 | Yes | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:24958724PhosphoSite:31113864PhosphoSite:21123652 |
Page 3 of 3Previous
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 1 | 38113368 |
Sequence, Structure & Domains
Sequences
Length
529
Mass
59,479
Sequence
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
3D Structural Models
Turn
120..122; 189..191; 283..285; 514..516
Helix
130..132; 139..141; 151..158; 219..228; 260..262; 300..310; 342..345; 349..352; 356..375; 385..387; 392..394; 403..406; 422..424; 427..432; 437..452; 464..472; 485..494; 499..501; 505..513
Beta Strand
82..86; 92..95; 103..108; 112..119; 125..129; 133..135; 167..172; 174..176; 180..188; 192..202; 204..206; 208..211; 216..218; 231..235; 249..252; 263..271; 273..282; 286..293; 321..325; 327..329; 331..334; 388..390; 396..398; 407..412; 522..524
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
77..138; SH3; 144..241; SH2; 263..516; Protein kinase
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Proto-oncogene
Drugs (21)
COMPOUND 31 [PMID: 24915291]RIPK3 INHIBITOR 18TG100-801COMPOUND 23 [PMID: 17600705]COMPOUND 2C [PMID: 24900538]APITOLISIBBOSUTINIBENMD-981693ILORASERTIBACALABRUTINIBXL-228COMPOUND 7 [PMID: 22464456]P505-15ECF506COMPOUND 9 [PMID: 26006010]COMPOUND 38 [PMID: 24915291]RECOMBINANT CYTOKINECOMPOUND 2 [PMID: 15546730]DASATINIB ANHYDROUSPRN694IBRUTINIB
Antibody
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications6
| PMID | Title | Related sentences |
|---|---|---|
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 34576246 | Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38354507 | Separation of high-purity plasma extracellular vesicles for investigating proteomic signatures in diabetic retinopathy. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |