Protein detail
FGR
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Protein symbol FGR | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Protein Class
Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
c-fgrp55c-fgrSRC2
Gene Description
FGR proto-oncogene, Src family tyrosine kinase
Chromosome
1
Position
27612064-27635185
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive CD8 T-cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
- GO:0005576 extracellular region
- GO:0005743 mitochondrial inner membrane
- GO:0005758 mitochondrial intermembrane space
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0016235 aggresome
- GO:0032587 ruffle membrane
- GO:0034774 secretory granule lumen
- GO:0070062 extracellular exosome
Molecular Function
- GO:0001784 phosphotyrosine residue binding
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019901 protein kinase binding
- GO:0034987 immunoglobulin receptor binding
- GO:0034988 Fc-gamma receptor I complex binding
Biological Process
Reactome
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9664407 parasite infection
- R-hsa-418346 platelet homeostasis
- R-hsa-432142 platelet sensitization by ldl
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| FGR | INSR | P06213 | Y | 412 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
22 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FGR | P09769 | LOX5 | P09917 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:24860872 |
| FGR | P09769 | RIPK2 | O43353 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:24958724PhosphoSite:31113864PhosphoSite:21123652 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 1 | 38113368 |
Sequence, Structure & Domains
Sequences
Length
529
Mass
59,479
Sequence
MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
3D Structural Models
Turn
120..122; 189..191; 283..285; 514..516
Helix
130..132; 139..141; 151..158; 219..228; 260..262; 300..310; 342..345; 349..352; 356..375; 385..387; 392..394; 403..406; 422..424; 427..432; 437..452; 464..472; 485..494; 499..501; 505..513
Beta Strand
82..86; 92..95; 103..108; 112..119; 125..129; 133..135; 167..172; 174..176; 180..188; 192..202; 204..206; 208..211; 216..218; 231..235; 249..252; 263..271; 273..282; 286..293; 321..325; 327..329; 331..334; 388..390; 396..398; 407..412; 522..524
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
77..138; SH3; 144..241; SH2; 263..516; Protein kinase
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Proto-oncogene
Drugs
COMPOUND 31 [PMID: 24915291]RIPK3 INHIBITOR 18TG100-801COMPOUND 23 [PMID: 17600705]COMPOUND 2C [PMID: 24900538]APITOLISIBBOSUTINIBENMD-981693ILORASERTIBACALABRUTINIBXL-228COMPOUND 7 [PMID: 22464456]P505-15ECF506COMPOUND 9 [PMID: 26006010]COMPOUND 38 [PMID: 24915291]RECOMBINANT CYTOKINECOMPOUND 2 [PMID: 15546730]DASATINIB ANHYDROUSPRN694IBRUTINIB
Antibody
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid