EV MemProt Atlas

Basic Information

Protein Names

Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)

Protein Class

Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Ensembl

ENSG00000000938

Entrez Gene Symbol

FGR

Gene Synonym

c-fgrp55c-fgrSRC2

Gene Description

FGR proto-oncogene, Src family tyrosine kinase

Chromosome

1

Position

27612064-27635185

Frequency

6

EVMP Score

0.63

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell Specificnaive CD8 T-cell

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04062 Chemokine signaling pathway

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

21 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FGR	CSK	P41240	Y	523	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMLi2012SIGNOR_ProtMapper	HPRD:7515063 KEA:8612628 HPRD:8612628 ProtMapper:7515063 KEA:7515063 phosphoELM:7515063
FGR	CSK	P41240	Y	412	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:16537894 ProtMapper:11489946 ProtMapper:14967142
FGR	SRC	P12931	Y	523	phosphorylation	dbPTM	dbPTM:19369195
FGR	ACVR1	Q04771	S	27	phosphorylation	PhosphoNetworks
FGR	SCYL2	Q6P3W7	S	27	phosphorylation	PhosphoNetworks
FGR	JAK2	O60674	Y	34	phosphorylation	PhosphoNetworks
FGR	JAK2	O60674	Y	412	phosphorylation	PhosphoNetworks
FGR	LCK	P06239	Y	34	phosphorylation	PhosphoNetworks
FGR	LCK	P06239	Y	412	phosphorylation	PhosphoNetworks
FGR	MATK	P42679	Y	34	phosphorylation	PhosphoNetworks

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Ligand-Receptor Signaling

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

22 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGR	P09769	ELMO1	Q92556	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:15952790
FGR	P09769	HCLS1	P14317	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	SIGNOR:10066823 KEA:9104825 HPRD-phos:10066823 phosphoELM:10066823 KEA:8578591 KEA:9183008 ProtMapper:10066823 HPRD:10066823 phosphoELM:9183008 dbPTM:10066823 KEA:96108162 dbPTM:8611520 KEA:10066823
FGR	P09769	KCND3	Q9UK17	Yes	Yes	No	SIGNOR	SIGNOR:22198508
FGR	P09769	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714
FGR	P09769	KSYK	P43405	Yes	Yes	No	DOMINOWangPhosphoPointSIGNORHPRDBioGRIDSPIKE_LCLit-BM-17	Lit-BM-17:15536084 DOMINO:15536084 BioGRID:11672534 SIGNOR:21746961 SPIKE_LC:15536084 HPRD:11672534 Lit-BM-17:11672534
CSK	P41240	FGR	P09769	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksNCI-PID_ProtMapperHPRDKinexus_KEAWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	HPRD:7515063 HINT:8612628 KEA:8612628 ProtMapper:11489946 HPRD:8612628 ProtMapper:14967142 ProtMapper:16537894 HINT:7515063 ProtMapper:7515063 ProtMapper:8612628 SIGNOR:7515063 HPRD-phos:7515063 iPTMnet:8612628 HPRD-phos:8612628 KEA:7515063 phosphoELM:7515063
FGR	P09769	TBK1	Q9UHD2	Yes	No	Yes	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:28618271
FGR	P09769	SRC	P12931	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEALi2012SIGNOR_ProtMapper	KEA:12387813 HPRD:12468645 ProtMapper:12387813 ProtMapper:9208935 KEA:9208935 KEA:3103926 HPRD:7678701 KEA:7678701 ProtMapper:7678701 iPTMnet:9208935 KEA:12468645 HPRD:9208935 SIGNOR:9208935 ProtMapper:12468645 HPRD:12387813
SRC	P12931	FGR	P09769	Yes	No	No	HPRDdbPTMSIGNOR	HPRD:12468645 HPRD:7678701 dbPTM:19369195 SIGNOR:9208935 HPRD:9208935 HPRD:12387813
FGR	P09769	NEMO	Q9Y6K9	Yes	No	Yes	SIGNORProtMapperInnateDBREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:23131831 SIGNOR:23131831 InnateDB:20098747

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Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CDK14 FGR	O94921 P09769	0:0	hu.MAPhu.MAP2
	FGR	P09769	2	PDB	PDB:7uy0

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	38113368

Sequence, Structure & Domains

Sequences

Length

529

Mass

59,479

Sequence

MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT

3D Structural Models

Turn

120..122; 189..191; 283..285; 514..516

Helix

130..132; 139..141; 151..158; 219..228; 260..262; 300..310; 342..345; 349..352; 356..375; 385..387; 392..394; 403..406; 422..424; 427..432; 437..452; 464..472; 485..494; 499..501; 505..513

Beta Strand

82..86; 92..95; 103..108; 112..119; 125..129; 133..135; 167..172; 174..176; 180..188; 192..202; 204..206; 208..211; 216..218; 231..235; 249..252; 263..271; 273..282; 286..293; 321..325; 327..329; 331..334; 388..390; 396..398; 407..412; 522..524

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

77..138; SH3; 144..241; SH2; 263..516; Protein kinase

Protein Families

Protein kinase superfamily
Tyr protein kinase family
SRC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Clinical Relevance

Disease Involvement

Proto-oncogene

Antibody

HPA002024

Interaction Protein

ENSG00000146648

Interaction Count

1

Interaction Dataset

intact_biogrid

Protein symbol FGR	UniProt ID P09769	EVMP score 0.63
Frequency 6	Transmembrane count	Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins