Protein detail
PPBI
Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)
Entry name PPBI | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 3 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
IAP
Gene Description
Alkaline phosphatase, intestinal
Chromosome
2
Position
232456125-232460753
Supporting publications (n)
3
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificNeutrophilsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (4)
Reactome (8)
- R-hsa-8935690 digestion
- R-hsa-8963743 digestion and absorption
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-556833 metabolism of lipids
- R-hsa-1483257 phospholipid metabolism
- R-hsa-163125 post translational modification synthesis of gpi anchored proteins
- R-hsa-597592 post translational protein modification
- R-hsa-1483166 synthesis of pa
Canonical Pathways (3)
- M33 Pid glypican 1pathway
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
Mediation Categories
Metabolism mediation
Relations & Evidence14
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | |||||
| extracellular | extracellular | OmniPath | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| peripheral | peripheral | UniProt_location | |||||
| peripheral | peripheral | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ALPIAP3B1AP3D1AP3M1AP3S1AP3S2EIF4A2PUS1UBCVAMP7 | O00203O14617P09923P0CG48P51809P59780Q14240Q92572Q9Y2T2Q9Y606 | 1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6617 | ||
| ALPIEIF3AEIF3BEIF3FEIF3HEIF3IEIF3JEIF4A1EIF4A2EIF4EEIF4G1EIF4G2EIF4G3PABPC1UBC | O00303O15372O43432O75822P06730P09923P0CG48P11940P55884P60842P78344Q04637Q13347Q14152Q14240 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4991 | ||
| ALPICCNA2CCNB1CCNB2CCNB3CDC20CDC27CDK1CDK2CKS1BNDST2 | O95067P06493P09923P14635P20248P24941P30260P52849P61024Q12834Q8WWL7 | 1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4638 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass SpectrometryFlow Cytometry | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
528
Mass
56,812
Sequence
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
Domain & Motif Annotations
Protein Families
Alkaline phosphatase family
Sequence Similarities
Belongs to the alkaline phosphatase family.
Clinical Relevance
Drugs (25)
HUMAN GIP(3-42)NH2TIOXOLONEGASTRIC INHIBITORY POLYPEPTIDECEPHALOCHROMINHAEMATOXYLINMK-0893HUMAN GIP(5-30)NH2CHEMBL:CHEMBL56393CHEMBL:CHEMBL2094652SULFURETINBENSERAZIDE HYDROCHLORIDECURCUMINTERPYRIDINEISOQUERCETINHUMAN GIP(3-30)NH2HUMAN GIP(1-30)NH2DIHYDRODAPHNODORIN BCHEMBL:CHEMBL234338THUNBERGINOL BTIRZEPATIDECHEMBL:CHEMBL1408276CHEMBL:CHEMBL146710CHEMBL:CHEMBL585591(+/-)-ERIODICTYOLMGIPANT-1
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No related sentences available |
| 33441949 | Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |