Protein detail
ZSC22
Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)
Entry name ZSC22 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteinsTranscription factors |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
HKR2ZNF50
Gene Description
Zinc finger and SCAN domain containing 22
Chromosome
19
Position
58326994-58342332
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway5
Protein Function (2)
- Predicted intracellular proteins
- Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component
Molecular Function (5)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence9
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ZSCAN16ZSCAN22ZSCAN23ZSCAN32 | P10073Q3MJ62Q9H4T2Q9NX65 | 0:0:0:0 | hu.MAP | |||
| ZKSCAN2ZNF394ZSCAN22ZSCAN30ZSCAN32 | P10073Q53GI3Q63HK3Q86W11Q9NX65 | 0:0:0:0:0 | hu.MAP2 | |||
| ZNF394ZSCAN16ZSCAN22ZSCAN32 | P10073Q53GI3Q9H4T2Q9NX65 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains9
Sequences
Length
491
Mass
54,561
Sequence
MAIPKHSLSPVPWEEDSFLQVKVEEEEEASLSQGGESSHDHIAHSEAARLRFRHFRYEEASGPHEALAHLRALCCQWLQPEAHSKEQILELLVLEQFLGALPPEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDPGAEPTEASCKQSDLGESEPSNVTETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSSKCRECRKMFQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQSTHLTQHQRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHITVLQ
Domain & Motif Annotations
Compositional Bias
214..224; Basic and acidic residues; 225..241; Polar residues
Zinc Finger
268..290; C2H2-type 1; 296..318; C2H2-type 2; 324..346; C2H2-type 3; 352..374; C2H2-type 4; 380..402; C2H2-type 5; 408..430; C2H2-type 6; 436..458; C2H2-type 7; 464..486; C2H2-type 8
Domain (FT)
49..131; SCAN box
Region
134..161; Disordered; 204..249; Disordered
Protein Families
Krueppel C2H2-type zinc-finger protein family
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Clinical Relevance4
Antibody
Interaction Protein (2)
ENSG00000140987ENSG00000171222
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |