Protein detail

ZSC22

Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)

Entry name
ZSC22
UniProt ID
P10073
EVMP confidence score
0.28
Supporting publications (n)
2
Transmembrane count
Protein classification
Predicted intracellular proteinsTranscription factors
Basic Information
Protein Names
Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)
Protein Class (2)
Predicted intracellular proteinsTranscription factors
Protein Function (2)
  • Predicted intracellular proteins
  • Transcription factors:Zinc-coordinating DNA-binding domains
Ensembl
ENSG00000182318
Entrez Gene Symbol
ZSCAN22
Gene Synonym (2)
HKR2ZNF50
Gene Description
Zinc finger and SCAN domain containing 22
Chromosome
19
Position
58326994-58342332
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (2)
  • Predicted intracellular proteins
  • Transcription factors:Zinc-coordinating DNA-binding domains
Cellular Component
GO:0005634 nucleus
Molecular Function (5)
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ZSCAN16ZSCAN22ZSCAN23ZSCAN32P10073Q3MJ62Q9H4T2Q9NX650:0:0:0hu.MAP
ZKSCAN2ZNF394ZSCAN22ZSCAN30ZSCAN32P10073Q53GI3Q63HK3Q86W11Q9NX650:0:0:0:0hu.MAP2
ZNF394ZSCAN16ZSCAN22ZSCAN32P10073Q53GI3Q9H4T2Q9NX650:0:0:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationDensity Gradient CentrifugationMass spectrometry54074098638416841276015993239672631070281
Sequence, Structure & Domains

Sequences

Length
491
Mass
54,561
Sequence
MAIPKHSLSPVPWEEDSFLQVKVEEEEEASLSQGGESSHDHIAHSEAARLRFRHFRYEEASGPHEALAHLRALCCQWLQPEAHSKEQILELLVLEQFLGALPPEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDPGAEPTEASCKQSDLGESEPSNVTETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSSKCRECRKMFQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQSTHLTQHQRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHITVLQ

Domain & Motif Annotations

Compositional Bias
214..224; Basic and acidic residues; 225..241; Polar residues
Zinc Finger
268..290; C2H2-type 1; 296..318; C2H2-type 2; 324..346; C2H2-type 3; 352..374; C2H2-type 4; 380..402; C2H2-type 5; 408..430; C2H2-type 6; 436..458; C2H2-type 7; 464..486; C2H2-type 8
Domain (FT)
49..131; SCAN box
Region
134..161; Disordered; 204..249; Disordered
Protein Families
Krueppel C2H2-type zinc-finger protein family
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Clinical Relevance
Antibody
HPA006471
Interaction Protein (2)
ENSG00000140987ENSG00000171222
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications2
PMIDTitleRelated sentences
37922300Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available