Protein detail

ZSC22

Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)

Entry name ZSC22	UniProt ID P10073	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Zinc finger and SCAN domain-containing protein 22 (Krueppel-related zinc finger protein 2) (Protein HKR2) (Zinc finger protein 50)

Protein Class

Predicted intracellular proteinsTranscription factors

Protein Function

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000182318

Entrez Gene Symbol

ZSCAN22

Gene Synonym

HKR2ZNF50

Gene Description

Zinc finger and SCAN domain containing 22

Chromosome

Position

58326994-58342332

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBrain excitatory neurons

Function & Pathway

Protein Function

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component

GO:0005634 nucleus

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
ZSCAN16 ZSCAN22 ZSCAN23 ZSCAN32	P10073 Q3MJ62 Q9H4T2 Q9NX65	0:0:0:0	hu.MAP
ZKSCAN2 ZNF394 ZSCAN22 ZSCAN30 ZSCAN32	P10073 Q53GI3 Q63HK3 Q86W11 Q9NX65	0:0:0:0:0	hu.MAP2
ZNF394 ZSCAN16 ZSCAN22 ZSCAN32	P10073 Q53GI3 Q9H4T2 Q9NX65	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient Centrifugation	Mass spectrometry	5	40740986 38416841 27601599 32396726 31070281

Sequence, Structure & Domains

Sequences

Length

491

Mass

54,561

Sequence

MAIPKHSLSPVPWEEDSFLQVKVEEEEEASLSQGGESSHDHIAHSEAARLRFRHFRYEEASGPHEALAHLRALCCQWLQPEAHSKEQILELLVLEQFLGALPPEIQAWVGAQSPKSGEEAAVLVEDLTQVLDKRGWDPGAEPTEASCKQSDLGESEPSNVTETLMGGVSLGPAFVKACEPEGSSERSGLSGEIWTKSVTQQIHFKKTSGPYKDVPTDQRGRESGASRNSSSAWPNLTSQEKPPSEDKFDLVDAYGTEPPYTYSGKRSSKCRECRKMFQSASALEAHQKTHSRKTPYACSECGKAFSRSTHLAQHQVVHTGAKPHECKECGKAFSRVTHLTQHQRIHTGEKPYKCGECGKTFSRSTHLTQHQRVHTGERPYECDACGKAFSQSTHLTQHQRIHTGEKPYKCDACGRAFSDCSALIRHLRIHSGEKPYQCKVCPKAFAQSSSLIEHQRIHTGEKPYKCSDCGKAFSRSSALMVHLRIHITVLQ

3D Structural Models

Domain & Motif Annotations

Compositional Bias

214..224; Basic and acidic residues; 225..241; Polar residues

Zinc Finger

268..290; C2H2-type 1; 296..318; C2H2-type 2; 324..346; C2H2-type 3; 352..374; C2H2-type 4; 380..402; C2H2-type 5; 408..430; C2H2-type 6; 436..458; C2H2-type 7; 464..486; C2H2-type 8

Domain (FT)

49..131; SCAN box

Region

134..161; Disordered; 204..249; Disordered

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance

Antibody

HPA006471

Interaction Protein

ENSG00000140987ENSG00000171222

Interaction Count

Interaction Dataset

intact_biogrid