Protein detail
PPBN
Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)
Protein symbol PPBN | UniProt ID | EVMP score 0.63 |
Frequency 9 | Transmembrane count | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Alkaline phosphatase, germ cell type (EC 3.1.3.1) (ALP-1) (Alkaline phosphatase Nagao isozyme) (Alkaline phosphatase, placental-like) (Germ cell alkaline phosphatase) (GCAP) (Placental alkaline phosphatase-like) (PLAP-like)
Protein Class
EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
ALPPL2GCAP
Gene Description
Alkaline phosphatase, germ cell
Chromosome
2
Position
232406844-232410714
Frequency
9
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEnteric stem cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Enzymes
- FDA approved drug targets:Small molecule drugs
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38343172 |
Sequence, Structure & Domains
Sequences
Length
532
Mass
57,377
Sequence
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
3D Structural Models
Domain & Motif Annotations
Compositional Bias
431..443; Polar residues
Region
422..443; Disordered
Protein Families
Alkaline phosphatase family
Sequence Similarities
Belongs to the alkaline phosphatase family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
CHEMBL:CHEMBL146710HAEMATOXYLINNNC1702MYRICETINMK-0893GLUCAGON (RDNA)CHEMBL:CHEMBL56393CHEMBL:CHEMBL587759TIOXOLONECHEMBL:CHEMBL2094652SULFURETINCHEMBL:CHEMBL1198140TERPYRIDINEDECYNIUM 22CEPHALOCHROMINAMIFOSTINE ANHYDROUSBENSERAZIDE HYDROCHLORIDEL-168,049CROTEDUMABCURCUMINCHEMBL:CHEMBL1408276CHEMBL:CHEMBL598663EPICATECHINCHEMBL:CHEMBL234338NNC 92-1687BAY27-9955[125I]GLUCAGON (HUMAN, MOUSE, RAT)CHEMBL:CHEMBL1731432HGCGR ANTAGONISTDIHYDRODAPHNODORIN BCHEMBL:CHEMBL585591NNC0640(+/-)-ERIODICTYOLADOMEGLIVANT