Protein detail
KIT
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Protein symbol KIT | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins |
Basic Information
Protein Names
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteins
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
525..545; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C-KitCD117PBTSCFR
Gene Description
KIT proto-oncogene, receptor tyrosine kinase
Chromosome
4
Position
54657267-54740783
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificretinaBrain Regional SpecificcerebellumCell SpecificCone photoreceptor cellsSingle-Nuclei Brain Specificupper rhombic lip
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Cancers:Cancers of male genital organs
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
- GO:0002020 protease binding
- GO:0004713 protein tyrosine kinase activity
- GO:0004714 transmembrane receptor protein tyrosine kinase activity
- GO:0005020 stem cell factor receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0019838 growth factor binding
- GO:0019955 cytokine binding
- GO:0042169 SH2 domain binding
- GO:0042803 protein homodimerization activity
- GO:0046872 metal ion binding
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05221 Acute myeloid leukemia
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05230 Central carbon metabolism in cancer
Reactome
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927426 developmental lineage of mammary gland alveolar cells
- R-hsa-9927418 developmental lineage of mammary gland luminal epithelial cells
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-1433559 regulation of kit signaling
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-9669938 signaling by kit in disease
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-1433557 signaling by scf kit
- R-hsa-8866910 tfap2 ap 2 family regulates transcription of growth factors and their receptors
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
- R-hsa-8864260 transcriptional regulation by the ap 2 tfap2 family of transcription factors
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
18 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| KIT | PRKCA | P17252 | S | 821 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | HPRD:7539802phosphoELM:7539802ProtMapper:7539802KEA:7539802SIGNOR:7539802 |
| KIT | PRKCA | P17252 | S | 746 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:7539802phosphoELM:7539802ProtMapper:7539802KEA:7539802SIGNOR:7539802 |
| KIT | PRKCA | P17252 | S | 959 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | HPRD:7539802phosphoELM:7539802ProtMapper:7539802KEA:7539802SIGNOR:7539802 |
| KIT | PRKCA | P17252 | S | 741 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:7539802phosphoELM:7539802ProtMapper:7539802KEA:7539802SIGNOR:7539802 |
| KIT | SRC | P12931 | Y | 900 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapper | phosphoELM:12878163ProtMapper:12878163SIGNOR:12878163KEA:12878163 |
| KIT | PTPRG | P23470 | Y | 730 | dephosphorylation | SIGNOR | SIGNOR:25624455 |
| KIT | PTPRG | P23470 | Y | 703 | dephosphorylation | SIGNOR | SIGNOR:25624455 |
| KIT | PTPRG | P23470 | Y | 703 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:25624455 |
| KIT | PTPRG | P23470 | Y | 730 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:25624455 |
| KIT | PTPN6 | P29350 | Y | 570 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15526160 |
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Ligand-Receptor Signaling
64 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| growth_factor_binder | ligand_regulator | GO_Intercell | Yes | No | No | Yes | No |
| ligand_regulator | ligand_regulator | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
25 records.
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL1RAP-KIT complex | IL1RAPKIT | P10721Q9NPH3 | 0:0 | CORUM | CORUM:7510 | 20200353 |
| KITSOCS6 | O14544P10721 | 1:1 | PDB | PDB:2vif | ||
| KIT | P10721 | 2 | PDB | PDB:4pgzPDB:8pqfPDB:8pqaPDB:8pqdPDB:6gqlPDB:8pq9PDB:6gqkPDB:7khjPDB:8pqgPDB:8pqePDB:1pkgPDB:6ittPDB:6xvaPDB:7khkPDB:3g0fPDB:8pqcPDB:6gqjPDB:6gqmPDB:6xv9PDB:6xvb | ||
| KITKITLG | P10721P21583 | 2:2 | PDB | PDB:2e9wPDB:8dfqPDB:8dfmPDB:8dfp | ||
| KITPIK3R1 | P10721P27986 | 1:1 | PDB | PDB:2iuh | ||
| KITLG | P21583 | 4 | PDB | PDB:1exzPDB:1scf | ||
| KITLGKLHDC10 | P21583Q6PID8 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27894104 |
Sequence, Structure & Domains
Sequences
Length
976
Mass
109,865
Sequence
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=GNNK(+), KitA(+); IsoId=P10721-1; Sequence=Displayed; Name=2; Synonyms=GNNK(-), Kit(+); IsoId=P10721-2; Sequence=VSP_038385; Name=3; Synonyms=TR-KIT; IsoId=P10721-4; Sequence=VSP_060976
Alternative Sequence
1..744; MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRI -> MSLPLSFPFLTFMVVIAKKNPLFLT (in isoform 3); 510..513; Missing (in isoform 2)
3D Structural Models
Turn
166..168; 282..284; 818..820; 864..866; 931..933
Helix
89..91; 177..179; 384..386; 422..424; 481..483; 550..552; 573..575; 580..582; 586..588; 627..629; 631..647; 678..685; 686..689; 754..756; 760..762; 766..785; 795..797; 802..804; 812..814; 833..835; 838..843; 848..863; 877..885; 897..906; 911..913; 917..930
Beta Strand
38..41; 44..47; 54..59; 63..72; 75..77; 79..86; 93..99; 104..110; 125..127; 132..134; 146..149; 151..153; 161..165; 169..174; 183..188; 194..196; 200..205; 213..215; 219..224; 229..239; 243..248; 258..263; 265..267; 269..279; 286..293; 298..310; 312..319; 321..325; 331..341; 344..350; 356..364; 367..369; 372..379; 388..395; 400..409; 411..420; 425..434; 437..444; 445..449; 452..454; 458..462; 465..468; 472..479; 485..494; 499..506; 558..564; 567..570; 589..597; 599..609; 611..613; 617..625; 656..660; 662..664; 667..671; 674..677; 719..721; 757..759; 788..790; 798..801; 805..808; 821..824; 827..831; 869..872
3D Structure
Electron microscopy (3); X-ray crystallography (48)
Domain & Motif Annotations
Domain (FT)
27..112; Ig-like C2-type 1; 121..205; Ig-like C2-type 2; 212..308; Ig-like C2-type 3; 317..410; Ig-like C2-type 4; 413..507; Ig-like C2-type 5; 589..937; Protein kinase
Region
568..570; Important for interaction with phosphotyrosine-binding proteins
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsProto-oncogene
Related Diseases
Acute myeloid leukaemiaAlzheimer diseaseBone/articular cartilage neoplasmBrain cancerColorectal cancerGastrointestinal stromal tumourInflammatory arthropathyLiver cancerLung cancerMalignant intestine neoplasmMastocytosisMature B-cell lymphomaMultiple myelomaMyelodysplastic syndromeMyeloproliferative neoplasmPhakomatoses/hamartoneoplastic syndromePostoperative inflammationRenal cell carcinomaSolid tumour/cancerThrombocytopeniaTransplanted organ/tissue
Biomarker
Phase 1; Phase 3; Approved; Phase 2; Phase 1/2
Drug Targets
FDA approved drug targets
Drugs
IMATINIBENMD-2076PAZOPANIBNULLCRENOLANIBMIDOSTAURINRIPRETINIBADAVOSERTIBINFIGRATINIBAXITINIBAST-487XL820PEXIDARTINIBSORAFENIBVATALANIBREGORAFENIBDASATINIB ANHYDROUSQUIZARTINIBIDRX-42CENISERTIBPONATINIBOLVEREMBATINIBCEDIRANIBPEXIDARTINIB HYDROCHLORIDETANDUTINIBXL999MOTESANIBTIVOZANIB HYDROCHLORIDEBEZUCLASTINIBTORIPALIMAB-TPZIPEMBROLIZUMABLETROZOLEAMG-191SUNITINIBCABOZANTINIB S-MALATENILOTINIBAKT INHIBITOR MK2206GILTERITINIBTRAMETINIB DIMETHYL SULFOXIDEMASITINIBDERAZANTINIBBARASERTIBSP-600125FAMITINIBDOVITINIBAVAPRITINIBAMUVATINIBPI3K/BET INHIBITOR LY294002FF-10101MOTESANIB DIPHOSPHATEMIRDAMETINIBXL-820LINIFANIBCOPANLISIBSERALUTINIBJNJ-7706621CM-082CRIZOTINIBCYTARABINELENVATINIBROMIPLOSTIMVENETOCLAXILORASERTIBAZD3229TELATINIBBEVACIZUMAB-AWWBSEMAXANIBSNS-314PAZOPANIB HYDROCHLORIDETHE-630BINIMETINIBOSI-930RG-1530ENTRECTINIBNINTEDANIB ESYLATEFLUMATINIBANLOTINIBCYC-116GW843682XCHEMBL:CHEMBL578061BAY 61-3606SU-014813FORETINIBXL-999
Interaction Protein
ENSG00000049130ENSG00000105647ENSG00000124181ENSG00000141738ENSG00000145675ENSG00000167193ENSG00000177885
Interaction Count
7
Interaction Dataset
intact_biogrid