Protein detail

GHR

Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Protein symbol GHR	UniProt ID P10912	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Protein Class

Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Predicted secreted proteins
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

265..288; Helical

Transmembrane Count

Ensembl

ENSG00000112964

Entrez Gene Symbol

GHR

Gene Synonym

GHBP

Gene Description

Growth hormone receptor

Chromosome

Position

42423439-42721878

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Predicted secreted proteins
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M13 Pid erbb4 pathway
M128 Pid tnf pathway
M153 Pid p75 ntr pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

24 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GHR	JAK2	O60674	Y	332	phosphorylation	phosphoELMPhosphoNetworksKEA	phosphoELM:9121492 KEA:9121492
GHR	JAK2	O60674	Y	487	phosphorylation	phosphoELMPhosphoNetworksKEA	phosphoELM:9121492 KEA:9121492
GHR	JAK2	O60674	Y	566	phosphorylation	PhosphoNetworksKEA	KEA:9121492 KEA:8647880
GHR	JAK2	O60674	Y	534	phosphorylation	KEA	KEA:9121492 KEA:8647880
GHR	JAK2	O60674	Y	627	phosphorylation	KEA	KEA:9121492 KEA:8647880
GHR	PTPN1	P18031	Y	534	dephosphorylation	SIGNOR	SIGNOR:12907755
GHR	PTPN1	P18031	Y	566	dephosphorylation	SIGNOR	SIGNOR:12907755
GHR	PTPN1	P18031	Y	332	dephosphorylation	SIGNORDEPOD	SIGNOR:12907755 DEPOD:12907755
GHR	PTPN1	P18031	Y	487	dephosphorylation	SIGNORDEPOD	SIGNOR:12907755 DEPOD:12907755
GHR	PTPN1	P18031	Y	487	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:12907755

Page 1 of 3Next

Ligand-Receptor Signaling

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	DGIdb	No	No	Yes	Yes	No
extracellular	extracellular	LOCATE	No	No	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	LOCATE	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	Yes	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	Yes	Yes	No

Page 3 of 7Previous Next

Regulatory Interaction Network

14 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
JAK2	O60674	GHR	P10912	Yes	Yes	No	PhosphoNetworksphosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORHPRDCui2007PhosphoSite_KEAKEABioGRIDphosphoELM_KEAphosphoELMWang	HPRD:7540178 HPRD:10502458 BioGRID:21347402 HPRD:8063815 KEA:8647880 phosphoELM:9121492 SIGNOR:23071812 BioGRID:7540178 KEA:9121492 BioGRID:8063815 BioGRID:10502458
GHR	P10912	JAK2	O60674	Yes	Yes	No	WangKEGG-MEDICUSHPRDCui2007SignaLink3BioGRIDSPIKE_LCSPIKE	SignaLink3:18988627 HPRD:7540178 HPRD:10502458 BioGRID:21347402 HPRD:8063815 SignaLink3:9211920 SignaLink3:10502458 SPIKE:17312100 SignaLink3:8063815 SignaLink3:23331499 BioGRID:7540178 SPIKE_LC:17312100 SignaLink3:7540178 BioGRID:8063815 BioGRID:10502458
SOMA	P01241	GHR	P10912	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbICELLNETProtMapperSIGNORHINTSignaLink3InnateDBDIPLit-BM-17HPMR_talklrCellChatDBtalklrscConnectReactome_SignaLink3Cui2007IntActGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrBioGRIDCellinkerREACH_ProtMapperSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdb	IntAct:9353194 SignaLink3:1935820 Guide2Pharma:26713839 Lit-BM-17:17500058 IntAct:31279174 SIGNOR:7862673 Cellinker:31100495 Lit-BM-17:9353194 Cellinker:10551877 CellTalkDB:7862673 connectomeDB2020:7862673 HINT:11851338 ProtMapper:33312162 SignaLink3:3349036 Lit-BM-17:24280222 HINT:1549776 Lit-BM-17:9571026 SignaLink3:19927328 Lit-BM-17:8943276 Lit-BM-17:7862673 ICELLNET:2387255 HINT:9571026 SignaLink3:9030599 SignaLink3:2825030 HINT:17500058 HINT:8943276 SignaLink3:24243840 SPIKE_LC:9353194 Cellinker:7862673 HINT:1948064 SignaLink3:29145629 IntAct:8943276 SignaLink3:23331499 HINT:9353194 SignaLink3:7691587 SignaLink3:1549776 LRdb:7862673 InnateDB:21889455 HINT:7862673 DIP:9571026 BioGRID:7862673
GHR	P10912	TYK2	P29597	Yes	Yes	No	HPRDWangSignaLink3	SignaLink3:10502458 HPRD:10502458 SignaLink3:23331499
GHR	P10912	JAK1	P23458	Yes	Yes	No	HPRDWangSignaLink3	SignaLink3:10502458 HPRD:10502458 SignaLink3:23331499
PTN1	P18031	GHR	P10912	Yes	No	Yes	DOMINOSIGNORProtMapperDEPODIntActSIGNOR_ProtMapperLit-BM-17SPIKE_LC	SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755 IntAct:12907755 DEPOD:12907755 ProtMapper:12907755
EPHA4	P54764	GHR	P10912	Yes	Yes	No	SIGNOR	SIGNOR:28686668
DUS7	Q16829	GHR	P10912	Yes	No	Yes	DOMINOSPIKE_LCLit-BM-17SIGNOR	SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755
PTN9	P43378	GHR	P10912	Yes	No	Yes	DOMINOSPIKE_LCLit-BM-17SIGNOR	SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755
PTN3	P26045	GHR	P10912	Yes	No	Yes	DOMINOSIGNORProtMapperDEPODIntActSIGNOR_ProtMapperLit-BM-17SPIKE_LC	SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755 IntAct:12907755 DEPOD:12907755 ProtMapper:12907755

Page 1 of 2Next

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GH1 GHR	P01241 P10912	1:2	PDB	PDB:1a22PDB:1kf9PDB:3hhrPDB:1hwgPDB:1hwhPDB:1axi
GHR	P10912	2	PDB	PDB:5ohdPDB:5oekPDB:2aew
GHRHR	Q02643	2	PDB	PDB:2xdg

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains

Sequences

Length

638

Mass

71,500

Sequence

MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GHRfl; IsoId=P10912-1; Sequence=Displayed; Name=2; Synonyms=GHRtr, GHR1-279; IsoId=P10912-2; Sequence=VSP_010227, VSP_010228; Name=3; Synonyms=GHR1-277; IsoId=P10912-3; Sequence=VSP_010229, VSP_010230; Name=4; Synonyms=GHRd3; IsoId=P10912-4; Sequence=VSP_010225, VSP_010226

Alternative Sequence

24; A -> D (in isoform 4); 25..46; Missing (in isoform 4); 292..297; RIKMLI -> SSSSKD (in isoform 2); 292..294; RIK -> KEN (in isoform 3); 295..638; Missing (in isoform 3); 298..638; Missing (in isoform 2)

3D Structural Models

Turn

93..96; 104..107; 183..186

Helix

116..118; 143..146; 259..261; 266..292

Beta Strand

53..62; 64..68; 83..88; 111..114; 121..131; 134..142; 153..159; 167..176; 190..198; 210..221; 226..234; 240..243; 247..249

3D Structure

NMR spectroscopy (2); X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias

362..384; Basic and acidic residues

Motif

240..244; WSXWS motif; 297..305; Box 1 motif; 340..349; UbE motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (PubMed:14678285).; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).; DOMAIN: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

Domain (FT)

151..254; Fibronectin type-III

Region

260..262; Required for ADAM17-mediated proteolysis; 294..379; Required for JAK2 binding; 353..391; Disordered

Protein Families

Type I cytokine receptor family
Type 1 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Clinical Relevance

Disease Involvement

Disease variantDwarfismFDA approved drug targets

Related Diseases

COVID-19 Malaria Middle East Respiratory Syndrome Severe acute respiratory syndrome Binge eating disorder Obesity Pituitary gland disorder Short stature

Biomarker

Phase 3; Approved; Investigative; Phase 1; Discontinued in Phase 2

Drug Targets

FDA approved drug targetsSuccessful target

Drugs

SOMATROPIN (RECOMBINANT DNA ORIGIN)SOMAPACITAN PEGVISOMANT ACP-001 SOMATROGON ALBUSOMATROPIN LONAPEGSOMATROPIN ARX201 SOMATREM

Antibody

HPA045339 HPA057705

Interaction Protein

ENSG00000070159ENSG00000080031ENSG00000169410ENSG00000175354ENSG00000196396ENSG00000259384

Interaction Count

Interaction Dataset

intact_biogrid