Protein detail
GHR
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Entry name GHR | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Predicted secreted proteins
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
265..288; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
GHBP
Gene Description
Growth hormone receptor
Chromosome
5
Position
42423439-42721878
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Predicted secreted proteins
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0036464 cytoplasmic ribonucleoprotein granule
- GO:0043025 neuronal cell body
- GO:0043235 receptor complex
- GO:0070195 growth hormone receptor complex
Molecular Function
- GO:0004903 growth hormone receptor activity
- GO:0005515 protein binding
- GO:0008289 lipid binding
- GO:0017046 peptide hormone binding
- GO:0019838 growth factor binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0019955 cytokine binding
- GO:0042169 SH2 domain binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0070064 proline-rich region binding
Biological Process
KEGG
Reactome
Canonical Pathways
- M13 Pid erbb4 pathway
- M128 Pid tnf pathway
- M153 Pid p75 ntr pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
24 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GHR | JAK2 | O60674 | Y | 332 | phosphorylation | phosphoELMPhosphoNetworksKEA | phosphoELM:9121492KEA:9121492 |
| GHR | JAK2 | O60674 | Y | 487 | phosphorylation | phosphoELMPhosphoNetworksKEA | phosphoELM:9121492KEA:9121492 |
| GHR | JAK2 | O60674 | Y | 566 | phosphorylation | PhosphoNetworksKEA | KEA:9121492KEA:8647880 |
| GHR | JAK2 | O60674 | Y | 534 | phosphorylation | KEA | KEA:9121492KEA:8647880 |
| GHR | JAK2 | O60674 | Y | 627 | phosphorylation | KEA | KEA:9121492KEA:8647880 |
| GHR | PTPN1 | P18031 | Y | 534 | dephosphorylation | SIGNOR | SIGNOR:12907755 |
| GHR | PTPN1 | P18031 | Y | 566 | dephosphorylation | SIGNOR | SIGNOR:12907755 |
| GHR | PTPN1 | P18031 | Y | 332 | dephosphorylation | SIGNORDEPOD | SIGNOR:12907755DEPOD:12907755 |
| GHR | PTPN1 | P18031 | Y | 487 | dephosphorylation | SIGNORDEPOD | SIGNOR:12907755DEPOD:12907755 |
| GHR | PTPN1 | P18031 | Y | 487 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:12907755 |
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Ligand-Receptor Signaling
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| ligand | ligand | OmniPath | Yes | No | Yes | Yes | No |
| receptor | receptor | talklr | No | Yes | Yes | Yes | No |
| receptor | receptor | Cellinker | No | Yes | Yes | Yes | No |
| receptor | receptor | scConnect | No | Yes | Yes | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCall | No | Yes | Yes | Yes | No |
| receptor | receptor | iTALK | No | Yes | Yes | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
14 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTN2 | P17706 | GHR | P10912 | Yes | No | Yes | DOMINOSIGNORProtMapperHPRDIntActSIGNOR_ProtMapperLit-BM-17SPIKE_LC | HPRD:12907755SPIKE_LC:12907755DOMINO:12907755Lit-BM-17:12907755SIGNOR:12907755IntAct:12907755ProtMapper:12907755 |
| PTPRH | Q9HD43 | GHR | P10912 | Yes | No | Yes | Lit-BM-17SIGNORIntAct | Lit-BM-17:12907755IntAct:12907755SIGNOR:12907755 |
| GHR | P10912 | MP2K5 | Q13163 | Yes | Yes | No | SIGNOR | SIGNOR:23612709 |
| PTPRB | P23467 | GHR | P10912 | Yes | No | Yes | DOMINOSIGNORHINTIntActSPIKE_LCLit-BM-17 | IntAct:19167335SPIKE_LC:12907755DOMINO:12907755Lit-BM-17:12907755SIGNOR:12907755IntAct:12907755Lit-BM-17:19167335HINT:12907755 |
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
638
Mass
71,500
Sequence
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GHRfl; IsoId=P10912-1; Sequence=Displayed; Name=2; Synonyms=GHRtr, GHR1-279; IsoId=P10912-2; Sequence=VSP_010227, VSP_010228; Name=3; Synonyms=GHR1-277; IsoId=P10912-3; Sequence=VSP_010229, VSP_010230; Name=4; Synonyms=GHRd3; IsoId=P10912-4; Sequence=VSP_010225, VSP_010226
Alternative Sequence
24; A -> D (in isoform 4); 25..46; Missing (in isoform 4); 292..297; RIKMLI -> SSSSKD (in isoform 2); 292..294; RIK -> KEN (in isoform 3); 295..638; Missing (in isoform 3); 298..638; Missing (in isoform 2)
3D Structural Models
Turn
93..96; 104..107; 183..186
Helix
116..118; 143..146; 259..261; 266..292
Beta Strand
53..62; 64..68; 83..88; 111..114; 121..131; 134..142; 153..159; 167..176; 190..198; 210..221; 226..234; 240..243; 247..249
3D Structure
NMR spectroscopy (2); X-ray crystallography (9)
Domain & Motif Annotations
Compositional Bias
362..384; Basic and acidic residues
Motif
240..244; WSXWS motif; 297..305; Box 1 motif; 340..349; UbE motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (PubMed:14678285).; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).; DOMAIN: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.
Domain (FT)
151..254; Fibronectin type-III
Region
260..262; Required for ADAM17-mediated proteolysis; 294..379; Required for JAK2 binding; 353..391; Disordered
Protein Families
- Type I cytokine receptor family
- Type 1 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Clinical Relevance
Disease Involvement
Disease variantDwarfismFDA approved drug targets
Related Diseases
Biomarker
Phase 3; Approved; Investigative; Phase 1; Discontinued in Phase 2
Drug Targets
FDA approved drug targetsSuccessful target
Drugs
Interaction Protein
ENSG00000070159ENSG00000080031ENSG00000169410ENSG00000175354ENSG00000196396ENSG00000259384
Interaction Count
6
Interaction Dataset
intact_biogrid