Protein detail

GHR

Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Entry name GHR	UniProt ID P10912	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Protein Class

Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Predicted secreted proteins
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

265..288; Helical

Transmembrane Count

Ensembl

ENSG00000112964

Entrez Gene Symbol

GHR

Gene Synonym

GHBP

Gene Description

Growth hormone receptor

Chromosome

Position

42423439-42721878

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatids

Function & Pathway

Protein Function

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
Predicted secreted proteins
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M13 Pid erbb4 pathway
M128 Pid tnf pathway
M153 Pid p75 ntr pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

24 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GHR	PTPN2	P17706	Y	332	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:12907755
GHR	PTPN3	P26045	Y	534	dephosphorylation	SIGNORDEPOD	SIGNOR:12907755 DEPOD:12907755
GHR	PTPN3	P26045	Y	534	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:12907755
GHR	IGF1R	P08069	Y	566	phosphorylation	KEA	KEA:17570479

Page 3 of 3Previous

Ligand-Receptor Signaling

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

Page 7 of 7Previous

Regulatory Interaction Network

14 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTN2	P17706	GHR	P10912	Yes	No	Yes	DOMINOSIGNORProtMapperHPRDIntActSIGNOR_ProtMapperLit-BM-17SPIKE_LC	HPRD:12907755 SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755 IntAct:12907755 ProtMapper:12907755
PTPRH	Q9HD43	GHR	P10912	Yes	No	Yes	Lit-BM-17SIGNORIntAct	Lit-BM-17:12907755 IntAct:12907755 SIGNOR:12907755
GHR	P10912	MP2K5	Q13163	Yes	Yes	No	SIGNOR	SIGNOR:23612709
PTPRB	P23467	GHR	P10912	Yes	No	Yes	DOMINOSIGNORHINTIntActSPIKE_LCLit-BM-17	IntAct:19167335 SPIKE_LC:12907755 DOMINO:12907755 Lit-BM-17:12907755 SIGNOR:12907755 IntAct:12907755 Lit-BM-17:19167335 HINT:12907755

Page 2 of 2Previous

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GH1 GHR	P01241 P10912	1:2	PDB	PDB:1a22PDB:1kf9PDB:3hhrPDB:1hwgPDB:1hwhPDB:1axi
GHR	P10912	2	PDB	PDB:5ohdPDB:5oekPDB:2aew
GHRHR	Q02643	2	PDB	PDB:2xdg

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains

Sequences

Length

638

Mass

71,500

Sequence

MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=GHRfl; IsoId=P10912-1; Sequence=Displayed; Name=2; Synonyms=GHRtr, GHR1-279; IsoId=P10912-2; Sequence=VSP_010227, VSP_010228; Name=3; Synonyms=GHR1-277; IsoId=P10912-3; Sequence=VSP_010229, VSP_010230; Name=4; Synonyms=GHRd3; IsoId=P10912-4; Sequence=VSP_010225, VSP_010226

Alternative Sequence

24; A -> D (in isoform 4); 25..46; Missing (in isoform 4); 292..297; RIKMLI -> SSSSKD (in isoform 2); 292..294; RIK -> KEN (in isoform 3); 295..638; Missing (in isoform 3); 298..638; Missing (in isoform 2)

3D Structural Models

Turn

93..96; 104..107; 183..186

Helix

116..118; 143..146; 259..261; 266..292

Beta Strand

53..62; 64..68; 83..88; 111..114; 121..131; 134..142; 153..159; 167..176; 190..198; 210..221; 226..234; 240..243; 247..249

3D Structure

NMR spectroscopy (2); X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias

362..384; Basic and acidic residues

Motif

240..244; WSXWS motif; 297..305; Box 1 motif; 340..349; UbE motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (PubMed:14678285).; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.; DOMAIN: The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).; DOMAIN: The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

Domain (FT)

151..254; Fibronectin type-III

Region

260..262; Required for ADAM17-mediated proteolysis; 294..379; Required for JAK2 binding; 353..391; Disordered

Protein Families

Type I cytokine receptor family
Type 1 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Clinical Relevance

Disease Involvement

Disease variantDwarfismFDA approved drug targets

Related Diseases

COVID-19 Malaria Middle East Respiratory Syndrome Severe acute respiratory syndrome Binge eating disorder Obesity Pituitary gland disorder Short stature

Biomarker

Phase 3; Approved; Investigative; Phase 1; Discontinued in Phase 2

Drug Targets

FDA approved drug targetsSuccessful target

Drugs

SOMATROPIN (RECOMBINANT DNA ORIGIN)SOMAPACITAN PEGVISOMANT ACP-001 SOMATROGON ALBUSOMATROPIN LONAPEGSOMATROPIN ARX201 SOMATREM

Antibody

HPA045339 HPA057705

Interaction Protein

ENSG00000070159ENSG00000080031ENSG00000169410ENSG00000175354ENSG00000196396ENSG00000259384

Interaction Count

Interaction Dataset

intact_biogrid