Protein detail
CD8B
T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
Protein symbol CD8B | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count 1 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
Protein Class
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- CD markers
- Predicted intracellular proteins
Transmembrane
171..191; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD8B1
Gene Description
CD8b molecule
Chromosome
2
Position
86815339-86861924
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-182218 nef mediated cd8 down regulation
- R-hsa-164938 nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- R-hsa-164952 the role of nef in hiv 1 replication and disease pathogenesis
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 18 | 322848253561146236612172294367803037985537786918381689063940901534817906289865852163046227894104290455053095018531941606383215354008906734571828 |
Sequence, Structure & Domains
Sequences
Length
210
Mass
23,722
Sequence
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=M-1, Mbeta1; IsoId=P10966-1; Sequence=Displayed; Name=2; Synonyms=M-3, Mbeta2; IsoId=P10966-2; Sequence=VSP_002490; Name=3; Synonyms=S-1, Sbeta3; IsoId=P10966-3; Sequence=VSP_002492, VSP_002493; Name=4; Synonyms=M-2; IsoId=P10966-4; Sequence=VSP_002491; Name=5; Synonyms=Mbeta3; IsoId=P10966-6; Sequence=VSP_002493; Name=6; Synonyms=Sbeta1; IsoId=P10966-7; Sequence=VSP_002492; Name=7; Synonyms=Sbeta4; IsoId=P10966-8; Sequence=VSP_039654; Name=8; Synonyms=Sbeta5; IsoId=P10966-9; Sequence=VSP_039655
Alternative Sequence
165..210; GPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK -> DFTNKQRIGFWCPATKRHRSVMSTMWKNERRDTFNPGEFNGC (in isoform 7); 166..210; PLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK -> LKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS (in isoform 8); 166..195; Missing (in isoform 3 and isoform 6); 208..210; FYK -> LRLHPLEKCSRMDY (in isoform 2); 208..210; FYK -> PQGEGISGTFVPQCLHGYYSNTTTSQKLLNPWILKT (in isoform 3 and isoform 5); 208..210; FYK -> KFNIVCLKISGFTTCCCFQILQISREYGFGVLLQKDIGQ (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
22..132; Ig-like V-type
Clinical Relevance
Drugs
BUPROPION HYDROCHLORIDEDOTHIEPINVENLAFAXINEIMIPRAMINE HYDROCHLORIDELEVOMILNACIPRANNORZOTEPINE[3H]NISOXETINETRIMIPRAMINEMAPROTILINEATOMOXETINE HYDROCHLORIDEDEXTROAMPHETAMINE SULFATEN-DESALKYLQUETIAPINEDULOXETINE HYDROCHLORIDEZOTEPINEPHENELZINESIBUTRAMINENISOXETINEPROTRIPTYLINENOMIFENSINEREBOXETINESOLRIAMFETOLNORTRIPTYLINEDESIPRAMINETOLUDESVENLAFAXINELOFEPRAMINEAMOXAPINEAMITRIPTYLINE HYDROCHLORIDECITALOPRAMMETHYLPHENIDATE HYDROCHLORIDECLOMIPRAMINEDESVENLAFAXINE SUCCINATEMAZINDOLTAPENTADOLDOXEPIN HYDROCHLORIDEQUETIAPINE FUMARATEMILNACIPRANNEFAZODONE