Protein detail
CD8B
T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
Entry name CD8B | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
Protein Class (3)
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Transmembrane
171..191; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD8B1
Gene Description
CD8b molecule
Chromosome
2
Position
86815339-86861924
Supporting publications (n)
6
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificAdipocytesSingle-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
KEGG (6)
Reactome (9)
- R-hsa-1280218 adaptive immune system
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-198933 immunoregulatory interactions between a lymphoid and a non lymphoid cell
- R-hsa-5663205 infectious disease
- R-hsa-182218 nef mediated cd8 down regulation
- R-hsa-164938 nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
- R-hsa-164952 the role of nef in hiv 1 replication and disease pathogenesis
- R-hsa-9824446 viral infection pathways
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence30
Ligand-Receptor Signaling (29)
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| ligand | ligand | OmniPath | Yes | No | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | Yes | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 18 | 322848253561146236612172294367803037985537786918381689063940901534817906289865852163046227894104290455053095018531941606383215354008906734571828 |
Sequence, Structure & Domains6
Sequences
Length
210
Mass
23,722
Sequence
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
Alternative Products
Event=Alternative splicing; Named isoforms=8; Name=1; Synonyms=M-1, Mbeta1; IsoId=P10966-1; Sequence=Displayed; Name=2; Synonyms=M-3, Mbeta2; IsoId=P10966-2; Sequence=VSP_002490; Name=3; Synonyms=S-1, Sbeta3; IsoId=P10966-3; Sequence=VSP_002492, VSP_002493; Name=4; Synonyms=M-2; IsoId=P10966-4; Sequence=VSP_002491; Name=5; Synonyms=Mbeta3; IsoId=P10966-6; Sequence=VSP_002493; Name=6; Synonyms=Sbeta1; IsoId=P10966-7; Sequence=VSP_002492; Name=7; Synonyms=Sbeta4; IsoId=P10966-8; Sequence=VSP_039654; Name=8; Synonyms=Sbeta5; IsoId=P10966-9; Sequence=VSP_039655
Alternative Sequence
165..210; GPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK -> DFTNKQRIGFWCPATKRHRSVMSTMWKNERRDTFNPGEFNGC (in isoform 7); 166..210; PLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK -> LKGKVYQEPLSPNACMDTTAILQPHRSCLTHGS (in isoform 8); 166..195; Missing (in isoform 3 and isoform 6); 208..210; FYK -> LRLHPLEKCSRMDY (in isoform 2); 208..210; FYK -> PQGEGISGTFVPQCLHGYYSNTTTSQKLLNPWILKT (in isoform 3 and isoform 5); 208..210; FYK -> KFNIVCLKISGFTTCCCFQILQISREYGFGVLLQKDIGQ (in isoform 4)
Domain & Motif Annotations
Domain (FT)
22..132; Ig-like V-type
Clinical Relevance2
Drugs (37)
BUPROPION HYDROCHLORIDEDOTHIEPINVENLAFAXINEIMIPRAMINE HYDROCHLORIDELEVOMILNACIPRANNORZOTEPINE[3H]NISOXETINETRIMIPRAMINEMAPROTILINEATOMOXETINE HYDROCHLORIDEDEXTROAMPHETAMINE SULFATEN-DESALKYLQUETIAPINEDULOXETINE HYDROCHLORIDEZOTEPINEPHENELZINESIBUTRAMINENISOXETINEPROTRIPTYLINENOMIFENSINEREBOXETINESOLRIAMFETOLNORTRIPTYLINEDESIPRAMINETOLUDESVENLAFAXINELOFEPRAMINEAMOXAPINEAMITRIPTYLINE HYDROCHLORIDECITALOPRAMMETHYLPHENIDATE HYDROCHLORIDECLOMIPRAMINEDESVENLAFAXINE SUCCINATEMAZINDOLTAPENTADOLDOXEPIN HYDROCHLORIDEQUETIAPINE FUMARATEMILNACIPRANNEFAZODONE
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40829696 | Mining the plasma proteome: Evaluation of enrichment methods for depth and reproducibility. | No abstract available |