Protein detail
CD37
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)
Protein symbol CD37 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 4 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)
Protein Class
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- CD markers
- Predicted intracellular proteins
Transmembrane
18..38; Helical; 60..74; Helical; 86..111; Helical; 242..266; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
TSPAN26
Gene Description
CD37 molecule
Chromosome
19
Position
49335171-49343335
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificcDC
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
281
Mass
31,703
Sequence
MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P11049-1; Sequence=Displayed; Name=2; IsoId=P11049-2; Sequence=VSP_047228; Name=3; IsoId=P11049-3; Sequence=VSP_047228, VSP_047229
Alternative Sequence
1..68; Missing (in isoform 2 and isoform 3); 257..281; LGFMTLSIFLCRNLDHVYNRLARYR -> VIWPRPHPRSALNP (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Preclinical; Phase 1